Oxidative status in the lungs associated with tobacco smoke exposure

Doruk, Sibel; Özyurt, Hüseyın; Inonu, Handan; Erkorkmaz, Ünal; Saylan, Oguzhan; Seyfıklı, Zehra

doi:10.1515/cclm.2011.698

Cited by 27 publications

(41 citation statements)

References 25 publications

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“…Similar results can be seen in GST activities by smoking (P=0.048, OR=2.57, 95% CI: 1.01-6.57) and alcohol (P=0.081, OR=2.19, 95% CI: 0.91-5.25) status (Table 3). Several studies indicated that the levels of MDA were higher in smokers (Bindu et al, 2004;Doruk et al, 2011). The levels of peroxidation products viz., MDA, GPx and GST were increased in all the tissues of alcohol administered and smoke-exposed rats (Chelchowska et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Gao

Chen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Gao

Chen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Levels of 8-isoprostane, prostaglandin E 2 , leukotriene B 4 [ 84 , 85 ], H 2 O 2 [ 70 ] and TNF-α [ 80 ] increased, whilst levels of IL-1 β [ 80 ], glutathione (an important antioxidant) [ 83 ] and pH [ 76 ] decreased minutes after cigarette smoking. Similarly, increased levels of oxidative markers, including MDA, 8-hydroxydeoxyguanosine, superoxide dismutase and glutathione peroxidise, were identified in the EBC of smokers compared with non-smokers [ 86 ]. Smokers should thus refrain from smoking at least 3 h and preferably overnight before EBC collection to minimise effects on mediator levels.…”

Section: Smokingmentioning

confidence: 99%

Exhaled breath condensate: a comprehensive update

Ahmadzai

Huang²,

Hettiarachchi³

et al. 2013

Clinical Chemistry and Laboratory Medicine

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Since the late 1990s, a surge in interest in the analysis of exhaled breath condensate (EBC) resulted in the American Thoracic Society and European Respiratory Society (ATS/ERS) organising a Task Force in 2001 to develop guidelines on EBC collection and measurement of biomarkers. This Task Force published their guidelines in 2005 based on literature and expert opinions at that time, and multiple shortcomings and knowledge deficits were also identified. The clinical application of EBC collection and its biomarkers are currently still limited by several of these knowledge gaps, hence further guidelines for standardisation are required to ensure external validity. Using related articles produced since the publication of the ATS/ERS Task Force report, this paper attempts to provide a comprehensive update to the original guideline and review the methodological shortcomings identified. This review can hopefully serve as a yardstick for future studies involving this emerging clinical tool.

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“…21 Some biomarkers are available for evaluating the oxidative stress in living organisms. 22 Some of these biomarkers are malondialdehyde, 8-oxo-7,8-dihydro-2Ј-deoxyguanosine, and coenzyme Q10. Each of these biomarkers is involved in oxidative processes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome

et al. 2015

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BACKGROUND: Oxidative damage is a major contributing factor to carcinogenesis and obstructive disorders in lungs. Current evidence suggests that the inflammatory processes yield to oxidative mechanisms, which underlie COPD, lung cancer, and obstructive sleep apnea syndrome (OSAS). This study aimed to evaluate the oxidative damage in these diseases by evaluating the oxidative and antioxidant biomarkers. METHODS: Malondialdehyde, 8-oxo-7,8-dihydro-2-deoxyguanosine, and coenzyme Q10 levels were evaluated in the blood samples of subjects with COPD, lung cancer, and OSAS by high-pressure liquid chromatography. RESULTS: A total of 111 participants (35 females, 76 males) with OSAS (n ‫؍‬ 29), COPD (n ‫؍‬ 26), and lung cancer (n ‫؍‬ 28) and healthy controls (n ‫؍‬ 28) were included in the study. The malondialdehyde and coenzyme Q10 levels were significantly higher in all 3 diseases when compared with controls (P < .01), whereas 8-oxo-7,8-dihydro-2-deoxyguanosine levels were only significantly higher than in healthy controls in subjects with lung cancer (P ‫؍‬ .005). The highest levels of malondialdehyde and coenzyme Q10 were determined in subjects with OSAS and lung cancer, respectively. The highest 8-oxo-7,8-dihydro-2-deoxyguanosine levels were also observed in subjects with lung cancer, but the differences of this biomarker with other diagnoses were not statistically significant (P ‫؍‬ .56). CONCLUSION: Oxidative damage was observed in all 3 diagnoses, and, as a response to oxidative stress, antioxidant mechanisms were also active in these diseases. Malondialdehyde and 8-oxo-7,8-dihydro-2-deoxyguanosine were found to be efficiently usable in the evaluation of oxidative damage in chronic respiratory diseases. (ClinicalTrials.gov registration NCT02406053.) Key words: malondialdehyde; 8-oxo-7,8-dihydro-2Ј-deoxyguanosine;coenzyme Q10; COPD; OSAS; lung cancer; oxidative damage; antioxidants. [Respir Care 2016;61(2):205-211.

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Oxidative status in the lungs associated with tobacco smoke exposure

Abstract: TS exposure affected the balance between oxidative stress and antioxidant capacity of lungs. Preventing environmental TS exposure might decrease oxidative damage. Increased levels of 8-OHdG and SOD levels could be assessed as an early sign of airway damage.

Cited by 27 publications

References 25 publications

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

Exhaled breath condensate: a comprehensive update

Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome

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