Oxidative Status and Lipid Profile in Metabolic Syndrome: Gender Differences

Abstract

Our findings indicate that women with metabolic syndrome have a better antioxidant status and higher ApoA levels compared with men. Our findings suggest the existence of a higher oxidative stress index in men with metabolic syndrome. Considering the higher risk of atherosclerosis associated with men, these novel oxidative stress parameters may be valuable in the evaluation of patients with metabolic sydrome.

Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

“…The antioxidant status becomes weak with age (5), with apparent poorer antioxidant status in men than in women (6). In agreement with this, we have found that cocoa consumption, adjusted for different models, has an effect on %ΔoxLDL of men, while in women this result was not observed.…”

“…Despite the presence of an antioxidant system in the human organism, the imbalance created when antioxidant system is weak and the production of reactive oxygen species is increased, favours the establishment of a harmful oxidative stress situation (4). Moreover, antioxidant status tends to be unfavourable with age (5), and it seems that the antioxidant protection is lower in men than in women (6).…”

Gender-specific relationships between plasma oxidized low-density lipoprotein cholesterol, total antioxidant capacity, and central adiposity indicators

“…Likewise, the gender implication in the relationship of adiposity indexes and oxidative stress markers has been modestly reported. 7,8 Overall, the aim of this cross-sectional study was to evaluate potential gender differences in associations of adiposity (total vs. central) with oxidative stress markers in apparently healthy young adults. We assessed plasma oxidized low-density lipoprotein cholesterol (ox-LDL) and total antioxidant capacity (TAC), and glutathione peroxidase (GPx) activity in erythrocytes, as recognized indicators of oxidative stress, and/or antioxidant status.…”

Clinical efficacy of oxidative stress correction by actovegin in diabetic polyneuropathy at type 2 diabetic patients with arterial hypertension

“…Дополнительно вычисляли индекс окислительного стресса (OSI) по формуле [7]: OSI = TOC / TAC × 100, где TOC -общая оксидативная способность, TAC -общая антиоксидантная способность. …”

“…Предиабетические формы патологии обмена углеводов в сочетании с нарушениями метаболизма липидов, систем регу-ляции АД, избыточным весом или ожирением формируют син-дром инсулинорезистентности. Его основным патогенетическим звеном является компенсаторная гиперинсулинемия в условиях умеренной глюкозо-и липотоксичности, выраженность и дли-тельность существования которых ухудшает резистентность к ин-сулину, инициирует и пролонгирует дисфункцию β-клетки [1,2,6,7]. Изучение синдрома инсулинорезистентности и СД2 откры-вает ранее мало исследованные общие патогенетические звенья этих заболеваний.…”