Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

Ibero-Baraibar, Idoia; Abete, Itziar; Navas-Carretero, Santiago; Massis-Zaid, A.; Martínez, J. Alfredo; Zulet, M. Ángeles

doi:10.1016/j.numecd.2013.09.017

Cited by 61 publications

(88 citation statements)

References 29 publications

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“…The sample size was estimated in 50 subjects as was previously reported [15], and was based on the expected differences in means and dispersion criteria with a p value < 0.05 and a statistical power of 80%. The distribution of the variables was assessed using the ShapiroeWilk test and data are expressed as mean (SD).…”

Section: Discussionmentioning

confidence: 99%

“…This study is based on an intervention trial of 4 weeks, designed as a double-blinded, randomised controlled trial to evaluate the effect of the daily consumption of ready-to-eat meals supplemented with 1.4 g of cocoa extract, within a hypocaloric diet, in middle-aged overweight/obese subjects [15]. Half of the sample was randomly assigned to control group and the other half to cocoa group (1.4 g of cocoa extract) following both groups a 15% energy restricted diet.…”

Section: Methodsmentioning

confidence: 99%

“…It was registered in www.clinicaltrials.gov: (NCT01596309). The design and more details about this study have been reported elsewhere [15].…”

Section: Methodsmentioning

confidence: 99%

“…Written informed consent was obtained from all the enrolled participants before the beginning of the study. Volunteers were screened according to the inclusion and exclusion criteria previously detailed [15]. Thus, subjects should be between 50 and 80 years, BMI between 27.0 and 35.5 kg/m 2 and maintaining a stable weight (<5% of weight variation) three months prior to the intervention.…”

Section: Subjectsmentioning

confidence: 99%

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Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…It was registered in www.clinicaltrials.gov: (NCT01596309). The design and more details about this study have been reported elsewhere [15].…”

Section: Methodsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

See 2 more Smart Citations

Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study

et al. 2015

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“…Additionally, the regular consumption of buckwheat cookies rich in rutin brought about lower activity of the circulating MPO in middle-aged females [91]. Similarly, a hypocaloric diet rich in cocoa extract markedly decreased the circulating MPO activity, but also the oxidised LDL-C level in humans [33].…”

Section: Effect Of Diet On Paraoxonase 1 and Myeloperoxidase Activitiesmentioning

confidence: 97%

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Malara

Kęska

Lutosławska

2016

Biomedical Human Kinetics

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SummaryThe purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes -paraoxonase 1 and myeloperoxidase -on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol) bring about atherosclerosis and an increased risk of cardiovascular disease (CVD) which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C) and increasing the HDL-cholesterol (HDL-C). However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes -paraoxonase 1 (PON1) and myeloperoxidase (MPO) -which markedly affect the properties of HDL-C and contribute to its anti -or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

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Effect of cocoa on blood pressure

Ried

Fakler

Stocks

2017

Cochrane Database of Systematic Reviews

148

137

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BackgroundHigh blood pressure is an important risk factor for cardiovascular disease, contributing to about 50% of cardiovascular events worldwide and 37% of cardiovascular-related deaths in Western populations. Epidemiological studies suggest that cocoa-rich products reduce the risk of cardiovascular disease. Flavanols found in cocoa have been shown to increase the formation of endothelial nitric oxide which promotes vasodilation and therefore blood pressure reduction. Here we update previous meta-analyses on the e ect of cocoa on blood pressure. ObjectivesTo assess the e ects on blood pressure of chocolate or cocoa products versus low-flavanol products or placebo in adults with or without hypertension when consumed for two weeks or longer. Search methodsThis is an updated version of the review initially published in 2012. In this updated version, we searched the following electronic databases from inception to November 2016: Cochrane Hypertension Group Specialised Register, CENTRAL, MEDLINE and Embase. We also searched international trial registries, and the reference lists of review articles and included trials. Selection criteriaRandomised controlled trials (RCTs) investigating the e ects of chocolate or cocoa products on systolic and diastolic blood pressure in adults for a minimum of two weeks duration. Data collection and analysisTwo review authors independently extracted data and assessed the risks of bias in each trial. We conducted random-e ects meta-analyses on the included studies using Review Manager 5. We explored heterogeneity with subgroup analyses by baseline blood pressure, flavanol content of control group, blinding, age and duration. Sensitivity analyses explored the influence of unusual study design. Main resultsThirty-five trials (including 40 treatment comparisons) met the inclusion criteria. Of these, we added 17 trials (20 treatment comparisons) to the 18 trials (20 treatment comparisons) in the previous version of this updated review.Trials provided participants with 30 to 1218 mg of flavanols (mean = 670 mg) in 1.4 to 105 grams of cocoa products per day in the active intervention group. The control group received either a flavanol-free product (n = 26 treatment comparisons) or a low-flavanol-containing cocoa powder (range 6.4 to 88 mg flavanols (mean = 55 mg, 13 treatment comparisons; 259 mg, 1 trial).

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Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet

Cited by 61 publications

References 29 publications

Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study

Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Effect of cocoa on blood pressure

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