Oxidative injury and neuropathy in diabetes and impaired glucose tolerance

Abstract

Clinical studies suggest that impaired glucose tolerance (IGT) is associated with the development of neuropathy. The aim of the current study was to determine if neuropathy developed in the female Zucker Diabetic Fatty (ZDF) rat, an animal model of IGT and type 2 diabetes. The ZDF rat develops impaired glucose tolerance (IGT) when fed a control diet, and frank diabetes when fed a high fat diet. Following 10 weeks of hyperglycemia, sensory nerve action potentials (SNAP) and compound motor action potentials (CMAP) were reduced and sensory conduction velocities were slowed (distal > proximal) in the tail and hind limb in ZDF animals with IGT and frank diabetes (p<0.01). Neuropathy was coupled with evidence of increased reactive oxygen species (ROS) and cellular injury in dorsal root ganglion (DRG) neurons from IGT animals. Our study supports the hypothesis that neuropathy develops in an animal model of IGT and is associated with evidence of oxidative injury in DRG and peripheral nerves.

Relationship between cardiovascular autonomic neuropathy and coronary artery calcification in patients with type 2 diabetes

“…Moreover a lower heart rate variability is associated with the development of coronary heart disease in diabetics [36], these observations taken together suggest that impaired cardiac autonomic control may elevate the risk of coronary heart disease. Further supporting this notion is that diabetic neuropathy and atherosclerosis are both well known to be associated with oxidative stress [30,37,38]. However, further research is needed to delineate the molecular mechanism through which CAN promotes the development of macrovascular complications like coronary artery atherosclerosis.…”

Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice

“…Herein, we showed that both high glucose and LPS administration induced extremely high level of ROS production. ROS and other chemical entities could result in the development of oxidative stress, which contributes to various complications associated with diabetes [41, 42]. LKB1 plays important roles in various biologic responses through regulation of multiple downstream kinases.…”

Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats

“…In brain, neuronal insulin signaling plays an important role in synaptic formation and regeneration of neurons in brain [4] and decreased levels or sensitivity is related with type 1 or 2 DM, respectively. Diabetes impairs the neuronal adaptive ability to oxidative and metabolic stress [16], and alters hippocampal neurogenesis and neuropathy in dorsal root ganglion [12,27]. Durationdependent differences like hippocampal neuronal apoptosis are reported [21].…”