2012
DOI: 10.1292/jvms.12-0036
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Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats

Abstract: ABSTRACT. In this study, we investigated diabetic stage dependent cyclooxygenase-2 (COX-2) immunoreactivity in the dentate gyrus in streptozotocin (STZ)-induced type 1 diabetic rats. The animals were sacrificed at 2, 3 and 4 weeks after STZ treatment. Blood glucose levels were increased after STZ treatment. COX-2 immunoreactivity in dentate gyrus was significantly increased in these regions 3 weeks after STZ treatment and restored to its basal level to 4 weeks after STZ treatment. In contrast, COX-2 immunoreac… Show more

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Cited by 5 publications
(5 citation statements)
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“…However, the COX-2 pathway is not essential for the promotion of neuronal maturation following treatment with AA extract. Although multiple studies have reported that COX-2 has a pivotal role in enhancing neurogenesis in the hippocampus [131415], our western blot results showed that COX-2 expression in the hippocampus did not significantly change with chronic AA administration in mice fed either of the diets. It may be that AA does not affect the COX-2-related pathways, but that an alternative signaling pathway enhances neurogenesis.…”
Section: Discussioncontrasting
confidence: 68%
“…However, the COX-2 pathway is not essential for the promotion of neuronal maturation following treatment with AA extract. Although multiple studies have reported that COX-2 has a pivotal role in enhancing neurogenesis in the hippocampus [131415], our western blot results showed that COX-2 expression in the hippocampus did not significantly change with chronic AA administration in mice fed either of the diets. It may be that AA does not affect the COX-2-related pathways, but that an alternative signaling pathway enhances neurogenesis.…”
Section: Discussioncontrasting
confidence: 68%
“…In addition, treadmill exercise in COX-2 knockout mice significantly increased neurogenesis in the dentate gyrus ( 28 ). With colleagues, we have also demonstrated that COX-2 immunoreactivity was significantly increased in the hippocampus 3 weeks after streptozotocin treatment ( 29 ), while cell proliferation and neuroblast differentiation were significantly decreased at 3 weeks after streptozotocin treatment ( 30 ). The induction of COX-2 subsequently increases the synthesis of prostaglandin E 2 (PGE 2 ).…”
Section: Discussionmentioning
confidence: 83%
“…Rats were randomly assigned to the following groups ( n = 8 per group): control (Con), sevoflurane (Sev), DM (DM), DM + sevoflurane (DM/Sev), DM + sevoflurane + celastrol (Cel). In the 3 diabetes groups (DM, DM/Sev, and Cel), rats were given intraperitoneal injections of 10% STZ (1 mg/ml; S0130; Sigma, USA) in citrate buffer at 60 mg/kg to induce DM [ 9 , 10 ]. The preparation and injection of STZ were done under aseptic conditions.…”
Section: Methodsmentioning
confidence: 99%
“…If the time allowed to elapse before beginning the inhalation procedure is too long, some diabetic rats may die of unknown causes or die during the exposure to sevoflurane. For these reasons and on the basis of findings from pilot study data reported by others [ 9 , 11 ], we began the inhalation procedure 20 days after intraperitoneal (IP) injection of STZ.…”
Section: Methodsmentioning
confidence: 99%