Oxidative injury and antioxidants in coronary artery bypass graft surgery: Off-pump CABG significantly reduces oxidative stress

Peripheral tissue metabolism during off-pump versus on-pump coronary artery bypass graft surgery: the microdialysis study☆

“…Several studies confirm the reduction of some postoperative complications associated with the cardiopulmonary bypass. The decrease in the systemic inflammatory response and lower activation of the inflammatory mediators following beating heart surgery [1], decrease in oxidative stress [2] or less myocardial injury with lower levels of myocardial markers [3].…”

A comparative study on oxidative stress and antioxidant status in ischemic stroke patients with and without diabetes

“…GSH depletion enhances cerebral ischemic injury. Shivakumar et al (22) and Akila et al (21) have shown that GSH levels have decreased in brain regions during reperfusion for 1 h after moderate or severe ischemia for 0-5 hours. The GSH was shown to reduce lethality, increase brain water levels and decrease MDA levels in cerebral ischemic rats when given immediately after ischemia suggesting that its anti ischemic effects are due, in part to inhibition of lipid peroxidative responses (23,24).…”

“…Recently increased oxidative stress and impaired anti oxidant defense have been suggested as a contributory factor for initiation and progression of complications in schizophrenia, diabetes, malaria and coronary artery diseases (6,19,20,21). To study the antioxidant potential of ischemic stroke patients we have included Glutathione (GSH), Uric acid and Ceruloplasmin in our study.…”

Molecular Studies on Coronary Artery Disease—A Review

“…Enhanced lipid peroxidation may occur as a result of the fact that, naturally occurring scavenging mechanisms are suppressed and the free radical generation processes are enhanced [91,92]. Recently, increased oxidative stress and impaired anti oxidant defense have been suggested as a contributory factor for initiation and progression of complications in CADs [93].…”