Oxidative DNA Damage Levels in Blood from Women at High Risk for Breast Cancer are Associated with Dietary intakes of Meats, Vegetables, and Fruits

Djurić, Zora; Depper, Janice B.; Uhley, Virginia; Smith, Daryn; Lababidi, Samir; Martino, Silvana; Heilbrun, Lance K.

doi:10.1016/s0002-8223(98)00119-9

Cited by 48 publications

(23 citation statements)

References 25 publications

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“…They hypothesized that urinary isoprostane levels reflect an earlier event in the biosynthesis and availability of these compounds compared to plasma levels measured at the same time. Lastly, Djuric et al (1998) reported that oxidative DNA damage levels (5-hydroxymethyluracil) in blood from women at high risk for breast cancer were negatively associated with intake of antioxidant-rich vegetables and fruits and positively associated with consumption of red meats.…”

Section: Discussionmentioning

confidence: 99%

Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

et al. 2004

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Background: Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. Objective: The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. Design: Participants (n ¼ 53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (a)-and gamma (g)-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F 2t -IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. Results: After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P ¼ 0.02) in a-tocopherol and a marginally significant 4.9% increase (P ¼ 0.07) in isoprostane levels when women consumed 30 g alcohol/day (P ¼ 0.06 and 0.05 for overall effect of alcohol on a-tocopherol and isoprostanes, respectively). The other antioxidants were not significantly modified by the alcohol treatment. Conclusions: These results suggest that moderate alcohol consumption increases some biomarkers of oxidative stress in postmenopausal women. Sponsorship: NCI, NIH and ARS, USDA.

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Section: Discussionmentioning

confidence: 99%

Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

et al. 2004

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“…) is associated with an increased risk of many chronic non-transmittable diseases (PEARSON et al 1983;KUBOW 1992;DJURIC et al 1998;FERRARI 1998a).…”

Section: Lipid Oxidation Measured By Tbarsmentioning

confidence: 99%

“…Studying the role of diet in DNA oxidation, DJURIC et al (1998) found a positive correlation between the meat consumption and oxidative DNA damage to human blood cells. These authors also determined a negative correlation between the vegetable consumption and oxidative DNA injury.…”

Section: Lipid Oxidation Measured By Tbarsmentioning

confidence: 99%

Lipid oxidation and quality parameters of sausages marketed locally in the town of Săo Paulo (Brazil)

Ferrari¹,

Torres²

2002

Czech J. Food Sci.

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Lipid oxidation constitutes one of the most important causes of the chemical deterioration of foods, especially meats. Many harmful effects on human health are associated with lipid oxidation. During a period of six weeks, samples were bought at random on city hall food markets (CHFMs) and were analysed for lipid oxidation (TBARS-test) and some quality factors -redox potential (Eh), pH and water activity (a w ). The mean of Eh was X ± σ n-1 = 39.03 ± 26.30 mV, ranging from -86.00 to 92.00 mV. pH mean value was X ± σ n-1 = 5.97 ± 0.27, ranging from 5.08 to 6.48. Comparing the CHFMs, no statistically significant differences were observed between them in respect to pH, Eh, and a w values. TBARS mean value was X ± σ n-1 = 0.44 ± 0.23 mg/kg, ranging from 0.38 ± 0.19 mg/kg (CHFM-6) to 0.58 ± 0.31 mg/kg (CHFM-2), with extreme values of 0.22 mg/kg and 1.08 mg/kg. No statistically significant correlations between TBA test values and all tested variables were detected. According to the sensorial analysis criteria of GREENE and CUMUZE (1981), 16.67% of sausage samples could be rejected and 11.11% revealed critical TBARS values.Keywords: lipid oxidation; sausages, meat; food market; quality factors Abbreviations: a w = water activity; CHFMs = City Hall Food Markets; Eh = redox potential; MDA = malonaldehyde; SP = State of Săo Paulo; TBARS = thiobarbituric-acid reactive substances

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“…Dietary patterns are thought to influence the onset and progression of these and other chronic and degenerative diseases (Willett, 2002). It is shown that a diet high in fruits reduced oxidative damage to DNA, thus preventing a critical step in the onset of carcinogenesis (Djuric et al, 1998). A majority of fruits are a rich source of vitamin C, carotenoids, and polyphenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization, Mineral Analysis, and Antioxidant Potential of Two Underutilized Berries (Carissa carandusandEleagnus conferta) from the Western Ghats of India

Patil

Pai

Pawar

et al. 2012

Critical Reviews in Food Science and Nutrition

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Diversity needs to be "conserved through use." Owing to the global need, the present study includes two underutilized berries, Carissa carandus and Eleagnus conferta, to explore their potential as supplementary food by evaluating their antioxidant activity and approximate chemical composition. Berries of E. conferta are a richer source of carotene, ascorbic acid, protein, and magnesium, whereas berries of C. carandus are rich in sugars, lipids, iron, and magnesium. The antioxidant properties of the berries and a comparative account on their performance using DPPH and FRAP assay was studied. Both assays revealed high activity in the peel extract of berries of C. carandus. The LC-MS/MS profile of C. carandus reveals the presence of eleven different polyphenolic compounds while E. conferta had only four of these compounds.

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Oxidative DNA Damage Levels in Blood from Women at High Risk for Breast Cancer are Associated with Dietary intakes of Meats, Vegetables, and Fruits

Cited by 48 publications

References 25 publications

Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

Lipid oxidation and quality parameters of sausages marketed locally in the town of Săo Paulo (Brazil)

Chemical Characterization, Mineral Analysis, and Antioxidant Potential of Two Underutilized Berries (Carissa carandusandEleagnus conferta) from the Western Ghats of India

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