Oxidative damage to DNA related to survivorship and carotenoid-based sexual ornamentation in the common yellowthroat

Freeman‐Gallant, Corey R.; Amidon, Joel; Berdy, Brittany; Wein, Stephanie; Taff, Conor C.; Haussmann, Mark F.

doi:10.1098/rsbl.2010.1186

Cited by 50 publications

(60 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These three measurements were taken for all blood samples, by making three slides per sample (untreated, challenge and repair). In SCGE, DNA damage levels are quantified as the average per cent DNA found in the electrophoresis-generated tail (damaged DNA migrates into tails [10]). In vivo DNA damage levels were quantified on 50 cells of an untreated slide.…”

Section: (C) Oxidative Stress Measuresmentioning

confidence: 99%

“…All analyses were run in duplicate and the intra-and inter-assay coefficients of variation were 4.01 and 4.33% for ROMs, and 3.85 and 4.45% for TAC. We used the SCGE assay [10] with modifications (see the electronic supplementary materials) to measure three distinct aspects of DNA damage and repair: in vivo DNA damage levels, vulnerability of DNA to a H 2 O 2 challenge and DNA repair efficiency. These three measurements were taken for all blood samples, by making three slides per sample (untreated, challenge and repair).…”

Section: (C) Oxidative Stress Measuresmentioning

confidence: 99%

“…Because oxidative damage negatively impacts reproduction [7,8] and survival [7,9,10], an individual's resistance to oxidative stress has fitness implications. One context in which the relationship between oxidative stress and fitness might be especially influential is in stressful early-life environments.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken ( Gallus gallus )

et al. 2013

View full text Add to dashboard Cite

Elevated levels of maternal androgens in avian eggs affect numerous traits, including oxidative stress. However, current studies disagree as to whether prenatal androgen exposure enhances or ameliorates oxidative stress. Here, we tested how prenatal testosterone exposure affects oxidative stress in female domestic chickens (Gallus gallus) during the known oxidative challenge of an acute stressor. Prior to incubation, eggs were either injected with an oil vehicle or 5 ng testosterone. At either 17 or 18 days post-hatch, several oxidative stress markers were assessed from blood taken before and after a 20 min acute stressor, as well as following a 25 min recovery from the stressor. We found that, regardless of yolk treatment, during both stress and recovery all individuals were in a state of oxidative stress, with elevated levels of oxidative damage markers accompanied by a reduced total antioxidant capacity. In addition, testosterone-exposed individuals exhibited poorer DNA damage repair efficiencies in comparison with control individuals. Our work suggests that while yolk androgens do not alter oxidative stress directly, they may impair mechanisms of oxidative damage repair.

show abstract

Section: (C) Oxidative Stress Measuresmentioning

confidence: 99%

Section: (C) Oxidative Stress Measuresmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken ( Gallus gallus )

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The Journal of Experimental Biology (2014) doi:10.1242/jeb.092825 components in birds (Freeman-Gallant et al, 2011;Noguera et al, 2012). This suggests that increasing antioxidant intake in cold conditions may have adaptive advantages, which may explain why this behavior has evolved.…”

Section: Research Articlementioning

confidence: 96%

Self-supplementation and effects of dietary antioxidants during acute thermal stress

Beaulieu

Haas

Schaefer

2013

Journal of Experimental Biology

View full text Add to dashboard Cite

Thermal stress leads to increased production of reactive oxygen species. If an organism is not able to simultaneously mount an efficient antioxidant defense system, this may lead to increased oxidative damage, which is potentially deleterious in terms of health and fitness. Exposure to cold or heat is therefore expected to be associated with a high demand for antioxidants. In agreement, several studies have shown that supplementing the diet of thermally stressed organisms with antioxidants leads to a reduction of oxidative damage. However, whether organisms can actively supplement their diet with antioxidants to alleviate temperature-induced oxidative damage is unknown. Here, we show that captive Gouldian finches (Erythrura gouldiae) supplement their diet more with seeds rich in antioxidants below than within their thermoneutral zone. Moreover, having access to seeds rich in antioxidants at temperatures below thermoneutrality decreases their oxidative damage. These results indicate that, when facing a thermal challenge, animals are able to take advantage of the antioxidant properties of their food to improve their oxidative balance. Having access to food resources rich in antioxidants may therefore be of primary importance for organisms in their natural habitat, as it may help them to cope with oxidative constraints due to challenging temperature regimes.

show abstract

“…Antioxidant capacity is positively, while oxidative damage negatively related to survival (Freeman-Gallant et al 2011;Saino et al 2011). Furthermore recent studies showed that the ability of nestlings to cope with oxidative stress predicts their fledging success (Losdat et al 2013) and their recruitment probability (Noguera et al 2012), highlighting that an efficient antioxidant protection is beneficial from the first stages of life.…”

Section: Introductionmentioning

confidence: 99%

Sex-specific effects of prenatal and postnatal nutritional conditions on the oxidative status of great tit nestlings

Giordano

Tschirren

2014

Oecologia

View full text Add to dashboard Cite

The early life period is characterized by fast growth and development, which can lead to high reactive oxygen species (ROS) production. Young animals thus have to balance their investment in growth versus ROS defence, and this balance is likely mediated by resource availability. Consequently resources transferred prenatally by the mother and nutritional conditions experienced shortly after birth may crucially determine the oxidative status of young animals. Here, we experimentally investigated the relative importance of pre-and early postnatal nutritional conditions on the oxidative status of great tit nestlings (Parus major). We show that resources transferred by the mother through the egg and nutritional conditions encountered after hatching affect the oxidative status of nestling in a sexspecific way. Daughters of non-supplemented mothers and daughters which did not receive extra food during the early postnatal period had higher oxidative damage than sons, while no differences between sons and daughters were found when extra food was provided pre-or postnatally. No effect of the food supplementations on growth, fledging mass or tarsus length was observed, indicating that female nestlings maintained their investment in growth at the expense of ROS defence mechanisms when resources were limited. The lower priority of the antioxidant defence system for female nestlings was also evidenced by lower levels of specific antioxidant components. These results highlight the important role of early parental effects in shaping oxidative stress in the offspring, and show that the sensitivity to these parental effects is sex-specific. 2 AbstractThe early life period is characterized by fast growth and development, which can lead to high reactive oxygen species (ROS) production. Young animals thus have to balance their investment in growth versus ROS defence, and this balance is likely mediated by resource availability. Consequently resources transferred prenatally by the mother and nutritional conditions experienced shortly after birth may crucially determine the oxidative status of young animals.Here we experimentally investigated the relative importance of pre-and early postnatal nutritional conditions on the oxidative status of great tit nestlings (Parus major). We show that resources transferred by the mother through the egg and nutritional conditions encountered after hatching affect the oxidative status of nestling in a sex-specific way. Daughters of non-supplemented mothers, and daughters, which did not receive extra food during the early postnatal period had higher oxidative damage than sons, while no differences between sons and daughters were found when extra food was provided pre-or postnatally. No effect of the food supplementations on growth, fledging mass or tarsus length was observed, indicating that female nestlings maintained their investment in growth at the expense of ROS defence mechanisms when resources were limited. The lower priority of the antioxidant defence system for female nestlings wa...

show abstract

Oxidative damage to DNA related to survivorship and carotenoid-based sexual ornamentation in the common yellowthroat

Cited by 50 publications

References 19 publications

Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken ( Gallus gallus )

Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken ( Gallus gallus )

Self-supplementation and effects of dietary antioxidants during acute thermal stress

Sex-specific effects of prenatal and postnatal nutritional conditions on the oxidative status of great tit nestlings

Contact Info

Product

Resources

About