Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken (
            <i>Gallus gallus</i>
            )

Treidel, Lisa A.; Whitley, Brittany N.; Benowitz-Fredericks, Z Morgan; Haussmann, Mark F.

doi:10.1098/rsbl.2013.0684

Cited by 36 publications

(32 citation statements)

References 17 publications

(34 reference statements)

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“…Recent evidence suggests that higher concentrations of yolk testosterone might directly or indirectly (i.e. through an increased growth rate [30]) impair antioxidant defences and increase the production of reactive oxygen and nitrogen species [8,9]. For example, chicks that have hatched from testosterone-injected eggs suffered from reduced plasma antioxidant levels [8] (zebra finch, Taeniopygia guttata) and DNA damage repair efficiency in response to an oxidative challenge [9] (domestic chickens, Gallus gallus).…”

Section: Discussionmentioning

confidence: 99%

“…through an increased growth rate [30]) impair antioxidant defences and increase the production of reactive oxygen and nitrogen species [8,9]. For example, chicks that have hatched from testosterone-injected eggs suffered from reduced plasma antioxidant levels [8] (zebra finch, Taeniopygia guttata) and DNA damage repair efficiency in response to an oxidative challenge [9] (domestic chickens, Gallus gallus). Our result suggests that species with a fast growth stimulated by high levels of yolk testosterone might counterbalance the negative effects of this developmental strategy on oxidative stress levels by allocating high levels of antioxidants, and particularly vitamin E, to their eggs.…”

Section: Discussionmentioning

confidence: 99%

“…testosterone or androstenedione) stimulates faster growth and increases the vulnerability to oxidative stress [8,9]. Maternally transmitted antioxidants such as carotenoids or vitamin E, by scavenging the reactive oxygen species (ROS) produced during development [10] and/or stimulating the set-up of an efficient antioxidant system [3], might limit the consequences of this increased level of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

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Co-adjustment of yolk antioxidants and androgens in birds

Giraudeau

Ducatez

2016

Biol. Lett.

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Mothers can shape the developmental trajectory of their offspring through the transmission of resources such as hormones, antioxidants or immunoglobulins. Over the last two decades, an abundant literature on maternal effects in birds has shown that several of these compounds (i.e. androgens, glucocorticoids and antioxidants) often influence the same offspring phenotypic traits (i.e. growth, immunity or oxidative stress levels), making interaction effects between egg components a likely scenario. However, the potential interactive effects of maternally transmitted compounds on offspring development and potential co-adjustment of these compounds within an egg are still poorly understood. Here, we report the results of an interspecific comparative analysis on birds' egg yolk composition (i.e. androgens and antioxidants) where we found that yolk carotenoid and vitamin E concentrations are positively associated, supporting the hypothesis that these two antioxidants act in synergy. The concentrations of vitamin E also increased with increasing concentrations of testosterone. This last result confirms the emerging idea that androgens and antioxidants are co-adjusted within eggs and that maternally transmitted antioxidants might limit the potential direct and indirect effects of prenatal exposure to high testosterone levels on oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Co-adjustment of yolk antioxidants and androgens in birds

Giraudeau

Ducatez

2016

Biol. Lett.

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“…This assay quantifies hydroperoxides, compounds that signal lipid and protein oxidative damage (Treidel et al, 2013); more ROMs are indicative of more oxidative activity in tissues and thus greater costs of inflammation. We optimized the assay by running dilution series on 10 individual house sparrow plasma samples and chose a dilution that fell at the midpoint between the calibrator and blank samples.…”

Section: Reactive Oxygen Metabolitesmentioning

confidence: 99%

“…Perhaps the best-studied introduced vertebrate species is the cane toad (Rhinella marina), which spread across Australia in ∼80 years (Phillips et al, 2006;Kolbe et al, 2009;Brown and Shine, 2014;Brown et al, 2015a,b;Rollins et al, 2015). Other non-native vertebrates, particularly rodents and songbirds (Losos et al, 1997;Kolbe et al, 2004;Lee et al, , 2005Fassbinder-Orth et al, 2013;Vilcinskas et al, 2013;White et al, 2013;Morand et al, 2015;Tian et al, 2015), have gained some recent attention, but the diversity of research approaches makes generalizations about facilitators of range expansions premature.…”

Section: Introductionmentioning

confidence: 99%

Costs of immunity and their role in the range expansion of the house sparrow in Kenya

Martin

Kilvitis

Brace

et al. 2017

Journal of Experimental Biology

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There are at least two reasons to study traits that mediate successful range expansions. First, dispersers will found new populations and thus impact the distribution and evolution of species. Second, organisms moving into new areas will influence the fate of resident communities, directly competing with or indirectly affecting residents by spreading non-native or spilling-back native parasites. The success of invaders in new areas is likely mediated by a counterbalancing of costly traits. In new areas where threats are comparatively rare, individuals that grow rapidly and breed prolifically should be at an advantage. High investment in defenses should thus be disfavored. In the present study, we compared the energetic, nutritional and collateral damage costs of an inflammatory response among Kenyan house sparrow (Passer domesticus) populations of different ages, asking whether costs were related to traits of individuals from three different capture sites. Kenya is among the world's most recent range expansions for this species, and we recently found that the expression of Toll-like receptors (TLRs), leukocyte receptors that instigate inflammatory responses when bound to microbial elements, was related to the range expansion across the country. Here, we found (contrary to our expectations) that energetic and nutritional costs of inflammation were higher, but damage costs were lower, in range-edge compared with core birds. Moreover, at the individual level, TLR-4 expression was negatively related to commodity costs (energy and a critical amino acid) of inflammation. Our data thus suggest that costs of inflammation, perhaps mediated by TLR expression, might mitigate successful range expansions.

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Maternal testosterone affects offspring telomerase activity in a long‐lived seabird

Noguera

Velando

2022

Ecology and Evolution

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Androgens are a group of steroid hormones that have long been proposed as a mechanism underpinning intergenerational plasticity. In birds, maternally allocated egg testosterone, one of the main androgens in vertebrates, affects a wide variety of offspring phenotypic traits but the mechanisms underlying this form of intergenerational plasticity are not yet well understood. Recent in vitro and animal model studies have shown that telomerase expression and activity are important targets of androgen signaling. The telomerase enzyme is known for its repair function on telomeres, the DNA–protein complexes at the ends of chromosomes that are involved in genomic integrity and cell aging. However, the role of maternal testosterone in influencing offspring telomerase levels in natural populations and its consequences on telomere length and potentially on offspring development is still unknown. Here, by experimentally modifying the level of egg testosterone in a natural population of yellow‐legged gull ( Larus michahellis ), we show that chicks hatched from testosterone‐treated eggs had higher average levels of telomerase and faster growth than controls during the first week of life. While testosterone‐treated chicks also tended to have longer telomeres than controls at hatching this difference disappeared by day 6 of age. Overall, our results suggest that maternal testosterone may have a potential adaptive value by promoting offspring growth and presumably telomerase levels, as this enzyme plays other important physiological functions (e.g., stress resistance, cell signaling, or tissue genesis) besides telomere lengthening. Nonetheless, our knowledge of the potential adaptive function of telomerase in natural populations is scarce and so the potential pathways linking maternal hormones, offspring telomerase, and fitness should be further investigated.

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Prenatal exposure to testosterone impairs oxidative damage repair efficiency in the domestic chicken ( Gallus gallus )

Cited by 36 publications

References 17 publications

Co-adjustment of yolk antioxidants and androgens in birds

Co-adjustment of yolk antioxidants and androgens in birds

Costs of immunity and their role in the range expansion of the house sparrow in Kenya

Maternal testosterone affects offspring telomerase activity in a long‐lived seabird

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