Oxidative Damage Markers Are Significantly Associated with the Carotid Artery Intima-Media Thickness after Controlling for Conventional Risk Factors of Atherosclerosis in Men

Yoon, Jin Ha; Kim, Jang Young; Park, Jong Ku; Ko, Sang Baek

doi:10.1371/journal.pone.0119731

Cited by 19 publications

(34 citation statements)

References 33 publications

(38 reference statements)

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“…In a patient with diabetes, ROS production, MDA level, and DNA damages are elevated, while the DNA repair system efficacy is reduced (Lee & Chan, 2015;Bhutia et al, 2011). Also, there is a causal link between MDA and 8-OHDG elevated levels in a variety of diseases such as cancer and cardiovascular disorders (Voulgaridou et al, 2011;Yoon et al, 2015). Thus, any therapeutic interventions that target the underlying causes for such complications are considered as appropriate approaches to improve the overall quality of life in these patients.…”

Section: Introductionmentioning

confidence: 99%

Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Homayouni

Haidari

Hedayati

et al. 2017

Phytotherapy Research

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This study aimed to examine the effects of hesperidin supplement on the glycemic parameters, oxidative DNA damage, and lipid peroxidation in patients with type 2 diabetes. Sixty‐four patients were randomly allocated to receive 500 mg/day hesperidin or placebo capsules for 6 weeks. Data on glycemic parameters, total antioxidant capacity (TAC), 8‐hydroxydeoxyguanosine (8‐OHDG), and malondialdehyde (MDA) were collected at the baseline and at the end of the study. In hesperidin group, TAC increased (0.74 ± 0.16 vs. 0.82 ± 0.18), while serum froctoseamin (5.79 ± 5.86 vs. 5.01 ± 4.95; p = 0.001), 8‐OHDG (14.32 ± 6.4 vs. 11.00 ± 7.0; p = 0.000), and MDA (5.78 ± 1.76 vs. 4.60 ± 0.75; p = 0.000) decreased in comparison with the baseline values. There was a significant difference in percent change of TAC (13.35 ± 19.21 vs. 3.13 ± 10.02; p = 0.043), froctoseamin (−10.10 ± 16.84 vs. 4.27 ± 34.646), 8‐OHDG (−25.11 ± 28.23 vs. 8.69 ± 35.41; p = 0.000), and MDA (−16.46 ± 18.04 vs. −1.82 ± 22.63; p = 0.007) between hesperidin and control groups following intervention in adjusted models. These results suggest that hesperidin may improve TAC and alleviate serum froctoseamin, 8‐OHDG, and MDA levels in type 2 diabetes. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Homayouni

Haidari

Hedayati

et al. 2017

Phytotherapy Research

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“…The levels of MDA and protein carbonyls were significantly higher in CAD cases as compared to without CAD cases. In a recent study by Yoon et al [21] showed that oxidative stress markers like MDA, 8-hydroxy-2 0 -deoxyquuanosine (8-OHdG) and 8-iso-prostaglandin F2a (Isoprostane) are independently associated with the increase in CIMT in men even after adjusting the cardiovascular risk factors like age, alcohol consumption, low density lipoprotein, BMI, smoking history, and metabolic syndrome. This indicates the role oxidative stress in the increase in CIMT.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of age was found in patients with various cardiovascular risk factors, including diabetes [20]. In a recent study, it was demonstrated that oxidative stress markers are independently associated with the increase in CIMT even after adjusting the conventional risk factors in men [21]. Hence the present study was carried out to investigate the role of oxidative stress markers and CIMT in elderly patients with cardiovascular risk factors without CAD and also in elderly patients with CAD.…”

Section: Introductionmentioning

confidence: 91%

Assessment of Oxidative Stress Markers and Carotid Artery Intima-Media Thickness in Elderly Patients Without and with Coronary Artery Disease

et al. 2015

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We aimed to assess whether measuring carotid intima-media thickness (CIMT) and oxidative stress markers such as protein carbonyls, malondialdehyde, nitrate and glutathione in plasma of elderly patients without and with coronary artery disease (CAD) identifies early risk for CAD. A total of 50 cases with cardiovascular risk factors over the age of 60 years without CAD, and 50 patients with angiographically documented CAD over the age of 60 years were included in the study. Control group consists of 200 healthy individuals without the risk factors. Demographic details were obtained from all the subjects and CIMT measured by high frequency ultrasound and oxidative stress markers such protein carbonyls, malondialdehyde and total glutathione were determined in plasma by spectrophotometric methods. The distribution of cardiovascular risk factors in without CAD and CAD cases were smokers (16 vs 56 %), hypertension (26 vs 64 %), diabetes (16 vs 56 %) and dyslipidemia (18 vs 58 %) and positive family history (4 vs 38 %). None of the control group had any cardiovascular risk factors. Among the CAD cases, 16 % had single vessel disease, 44 % had double vessel disease and 40 % had triple vessel disease. The CIMT was significantly increased in CAD cases as compared to cases without CAD and healthy controls. On the other hand, CIMT was significantly increased in cases without CAD as compared to healthy controls. CIMT also increased with the duration of diabetes in patients without CAD and severity of disease in CAD cases. The levels of oxidants like plasma malondialdehyde, protein carbonyls, were significantly elevated and antioxidant glutathione levels and nitrate levels were significantly reduced in cases with and without CAD as compared to healthy controls. Oxidative stress markers and CIMT was found to be significantly increased in patients with cardiovascular risk factors like diabetes, family history of CAD, dyslipidemia, hypertension and smoking when compared to patients without risk factors. In patients with diabetes, CIMT increased as duration of disease increases and also in poorly controlled diabetes. In CAD group, when number of vessel involvement (severity of coronary disease) increases, the CIMT also increases confirming that CIMT is a quantifiable risk factor for CAD.

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“…Furthermore, increased urinary excretion of 8-iso-PG F2α was also associated with increased carotid artery IMT. 21) In contrast, several clinical studies have demonstrated correlations between antioxidant Vol 57 No 2 OXIDATIVE STRESS AND CAROTID ATHEROSCLEROSIS markers and carotid artery IMT: SOD activity in diabetic patients, 18) catalase activity in chronic hemodialysis 17) and type 2 diabetic patients, 18) and serum TAS in workers occupationally exposed to mercury vapor 22) were negatively correlated with carotid artery IMT.…”

mentioning

confidence: 98%

mentioning

confidence: 99%

Biological Antioxidant Potential Negatively Correlates With Carotid Artery Intima-Media Thickness

et al. 2016

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SummaryOxidative stress is a crucial factor in the pathogenesis and development of cardiovascular disease. Recently, simplified methods for the detection of reactive oxygen species (ROS) using the derivatives of reactive oxygen metabolites (dROMs) test as an index of ROS products and the biological antioxidant potential (BAP) test as an index of antioxidant potential have been utilized. These methods are easy to perform, quick, inexpensive since they use small equipment, and provide reliable results compared with established oxidative stress and antioxidant markers. Because oxidative stress has been shown to represent the balance of production of ROS and antioxidant capacity, it is more appropriate to evaluate ROS and antioxidant capacity simultaneously. However, no study has examined the associations among d-ROMs, BAP values, and carotid artery intima-media thickness (IMT) concurrently. Therefore, we studied the associations among dROMs, BAP values, and the carotid artery IMT. Carotid artery IMT, blood pressure (BP), fasting circulating d-ROMs, BAP, glucose metabolism, lipid, and C-reactive protein levels were measured in 95 subjects (age: 49.5 ± 13.8 years; men: 41; women: 54), including 42 healthy subjects and 53 patients with hypertension, dyslipidemia, and diabetes mellitus who were not on medication. The results of multiple regression analysis revealed that dependent carotid artery IMT determinants remained significantly associated with age, systolic BP, total cholesterol, and BAP, whereas dependent BAP determinants remained significantly associated with body mass index and carotid artery IMT. BAP was strongly correlated with carotid artery IMT in our cohort. Our results suggest that BAP may be a useful risk marker for carotid atherosclerosis. (Int Heart J 2016; 57: 220-225) Key words: Antioxidant markers, Carotid atherosclerosis, Oxidative stress O xidative stress is involved as a crucial factor in the pathogenesis and development of a variety of chronic and degenerative diseases, including aging, cancer, and cardiovascular disease. An enhanced oxidative stress status, defined as an imbalance between oxidants and antioxidants in favor of the former, plays a significant role in the onset and progression of atherosclerosis.1-3) Levels of oxidative stress markers, such as thiobarbituric acid-reactive substances (TBARSs), 4) 8-iso-prostaglandin (PG) F 2 α, 5) oxidized low-density lipoprotein (LDL) (oxLDL), 6) and myeloperoxidase (MPO), 7,8) independently predict an increased risk for coronary artery disease (CAD). In contrast, glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase enzymes, and total antioxidant status (TAS) are antioxidant markers that constitute the first line of defense against oxidative stress by removing key reactive oxygen species (ROS).9) Meta-analyses of observational studies have identified inverse associations of circulating SOD, GPx, and catalase activity levels with CAD. 10)Furthermore, another study has demonstrated that a low GPx1 activity level was independently a...

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Oxidative Damage Markers Are Significantly Associated with the Carotid Artery Intima-Media Thickness after Controlling for Conventional Risk Factors of Atherosclerosis in Men

Cited by 19 publications

References 33 publications

Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Assessment of Oxidative Stress Markers and Carotid Artery Intima-Media Thickness in Elderly Patients Without and with Coronary Artery Disease

Biological Antioxidant Potential Negatively Correlates With Carotid Artery Intima-Media Thickness

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