Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Escobar, Jorge; Varela-Nallar, Lorena; Coddou, Claudio; Nelson, Pablo; Maisey, Kevin; Valdés, Daniel; Aspée, Alexis; Espinosa, Victoria; Rozas, Carlos; Montoya, Margarita; Mandiola, Cristian; Rodríguez, Felipe; Acuña-Castillo, Claudio; Escobar, Alejandro; Fernández, Ricardo; Díaz, Hernán; Sandoval, Mario; Imarai, Mónica; Rı́os, Miguel A.

doi:10.1155/2010/403830

Cited by 26 publications

(13 citation statements)

References 43 publications

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“…These findings concur with reports of elevated oxidative stress [27] and inflammation [21] in chronically-exposed adults. In a follow-up study ( n = 44), As levels in maternal urine and placental and cord blood positively associated with cord blood 8-hydroxy-2'-deoxyguanosine and inversely associated with infant thymic function at birth, as measured by signal-joint T-cell receptor-rearrangement excision circles in cord blood mononuclear cells (CBMC) [80].…”

Section: Epidemiological Findingssupporting

confidence: 92%

Arsenic immunotoxicity: a review

2013

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Exposure to arsenic (As) is a global public health problem because of its association with various cancers and numerous other pathological effects, and millions of people worldwide are exposed to As on a regular basis. Increasing lines of evidence indicate that As may adversely affect the immune system, but its specific effects on immune function are poorly understood. Therefore, we conducted a literature search of non-cancer immune-related effects associated with As exposure and summarized the known immunotoxicological effects of As in humans, animals and in vitro models. Overall, the data show that chronic exposure to As has the potential to impair vital immune responses which could lead to increased risk of infections and chronic diseases, including various cancers. Although animal and in vitro models provide some insight into potential mechanisms of the As-related immunotoxicity observed in human populations, further investigation, particularly in humans, is needed to better understand the relationship between As exposure and the development of disease.

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Section: Epidemiological Findingssupporting

confidence: 92%

Arsenic immunotoxicity: a review

2013

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“…We found that LYM and NEUT counts showed different degrees of decline after ATO exposure, resulting in an increased percentage of LYMs and a decreased percentage of NEUTs. The reason for this is unclear but we speculate that human exposure to arsenic induces oxidative damage in LYMs [24]. Additionally, ATO exposure may cause immune inhibition in rats, leading to changes in the LYM and NEUT populations [25].…”

Section: Discussionmentioning

confidence: 90%

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Su¹,

Sun²,

Wang³

et al. 2018

Infection International

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The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Wistar rats were randomly divided into four study groups that were treated with saline (control) or arsenic trioxide at a low (0.1 mg/mL), medium (1 mg/mL), or high (10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Compared with the control group, intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.

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“…In addition to polluting the environment, heavy metals are known to induce adverse health effects in people living in polluted areas. Previous studies have reported smelters in Mexico ( 2 3 ), the United States of America ( 4 ), and Chile ( 5 ), giving off fumes containing sufficient arsenic (As), lead (Pb), and cadmium (Cd) to make long-term health management necessary for nearby residents.…”

Section: Introductionmentioning

confidence: 99%

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

et al. 2016

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Concentrations of heavy metals exceed safety thresholds in the soil near Janghang Copper Refinery, a smelter in Korea that operated from 1936 to 1989. This study was conducted to evaluate the level of exposure to toxic metals and the potential effect on health in people living near the smelter. The study included 572 adults living within 4 km of the smelter and compared them with 413 controls group of people living similar lifestyles in a rural area approximately 15 km from the smelter. Urinary arsenic (As) level did not decrease according to the distance from the smelter, regardless of gender and working history in smelters and mines. However, in subjects who had no occupational exposure to toxic metals, blood lead (Pb) and cadmium (Cd) and urinary Cd decreased according to the distance from the smelter, both in men and women. Additionally, the distance from the smelter was a determinant factor for a decrease of As, Pb, and Cd in multiple regression models, respectively. On the other hands, urinary Cd was a risk factor for renal tubular dysfunction in populations living near the smelter. These results suggest that Janghang copper smelter was a main contamination source of As, Pb, and Cd, and populations living near the smelter suffered some adverse health effects as a consequence. The local population should be advised to make efforts to reduce exposure to environmental contaminants, in order to minimize potential health effects, and to pay close attention to any health problems possibly related to toxic metal exposure.

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Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Cited by 26 publications

References 43 publications

Arsenic immunotoxicity: a review

Arsenic immunotoxicity: a review

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

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