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The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Wistar rats were randomly divided into four study groups that were treated with saline (control) or arsenic trioxide at a low (0.1 mg/mL), medium (1 mg/mL), or high (10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Compared with the control group, intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.

The antifungal activity of griseofulvin was evaluated against phytopathogenic fungi including Fusarium moniliforme, Fusarium solani, Fusarium oxysporum and Colletotrichum truncatum. The greenhouse test was also made to evaluate the control efficiency of griseofulvin to eggplant powdery mildew. The results indicated griseofulvin could not only obviously inhibit fungi in laboratory experiments but efficiently control eggplant powdery mildew in greenhouse test. Subsequently, five griseofulvin analogues were synthesized and evaluated for antifungal activities against the four fungi. The results showed that these compounds performed significantly different activities in comparison with griseofulvin. The inhibition mechanism and bioavailability of active analogues were taken to expound their different performance and relations of structure and activity. The solubility in different solvents of analogues and griseofulvin was roughly evaluated and compared.