Oxidative damage and nephrotoxicity induced by prallethrin in rat and the protective effect of Origanum majorana essential oil

Refaie, Amel A.; Ramadan, Amal; Mossa, Abdel‐Tawab H.

doi:10.1016/s1995-7645(14)60282-0

Cited by 19 publications

(7 citation statements)

References 23 publications

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“…Amelioration of renal function in the current study might be a result of the antioxidant activity of OM extract, CAR, and Vit E. Previous studies indicated that OM extract had antioxidant activity. Also, it was able to inactivate hydroxyl radicals and hydrogen peroxide and inhibit lipid peroxidation [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats

Gheitasi

Azizi

Omidifar

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The most important cause of acute renal failure in normal kidneys is ischemia-reperfusion (I/R) injury. The aim of the current study was to investigate the protective effects of Origanum majorana (OM) methanolic extract, carvacrol, and vitamin E on I/R-induced kidney injury in male rats. Material and Method. Thirty Wistar male rats were randomly allocated into 5 groups; sham, I/R, I/R + OM (300 mg/kg), I/R + carvacrol (75 mg/kg), and I/R + vitamin E (100 mg/kg). Renal function markers, oxidant-antioxidant parameters, and histopathological examination were evaluated. Results. It was exhibited that the urea, creatinine, protein carbonyl, glomerular filtration rate, total thiol, ferric reducing antioxidant power, and histopathological changes markedly reversed in the treatment groups with OM or carvacrol in comparison to the I/R merely group. Conclusion. We conclude that OM extract or its ingredient, carvacrol, exerts renoprotective impacts in I/R-induced kidney injury possibly by scavenging free radicals and increasing antioxidant power.

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Section: Discussionmentioning

confidence: 99%

Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats

Gheitasi

Azizi

Omidifar

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…The expanded degrees of creatinine and BUN accumulation in the blood show a di culty in the kidney function in getting rid of these substances. Refaie et al [39] found a raised degree of urea in blood was associated with increase of protein catabolism in the mammalian body. They suggested that BUN level is increased due to increasing the alkylated urea derivatives in rats exposed to insecticide paralethrin.…”

Section: Discussionmentioning

confidence: 99%

DNA Damage and Expression Profile of Genes Associated with Nephrotoxicity Induced by Butralin and Ameliorating Effect of Arabic Gum in Female Rats

Refaie

Shalby

Kassem

et al. 2021

Appl Biochem Biotechnol

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Nephrotoxicity induced by exposure to environmental pollution including herbicides is became global problem. Natural products are the prime alternative of scienti c research as they express better medicinal activity and minor side effects compared with variety of synthetic drugs. This study was performed to evaluate the nephroprotective pro ciency of Arabic gum against butralin-induced nephrotoxicity. Adult female rats were supplemented with Arabic gum (4.3 g/kg b.wt) and/or butralin (312 mg/L) in drinking water for 30 days. The results found that markers of serum kidney function, oxidative stress biomarkers, DNA damage and expression of kidney speci c genes (Acsm2, ACE and ACE2) as well as histopathological examination in treated rats were conducted. Butralin-treated rats showed a rise in serum creatinine, BUN and MDA as well as decrease in activity of the antioxidant markers. In addition, butralin treatment increased the DNA damage, altered the expression levels of Acsm2, ACE and ACE2 and elevated histopathological lesions in kidney tissues. Pretreatment of Arabic gum prevented butralin-prompted degenerative changes of kidney tissues. The results suggested that the protective effect provided by Arabic gum on renal tissues exposed to the herbicide butralin could be attributed to enhancement of antioxidants and increase the free radicals scavenging activity in vivo.

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“…In addition, a stimulation of the immune defense mechanism of the animal may be suggested. Uric acid, urea, and creatinine are protein catabolism waste products that need to be excreted by the kidney [7] . Therefore, the significant increase in serum levels of such parameters as noticed after coragen administration in the present study, confirmed a disturbance in kidney functions.…”

Section: Discussionmentioning

confidence: 99%

“…The use of natural antioxidants such as herbal and natural products for curing pesticides-induced hematological changes [3] and renal toxicity/injury [7] has been extensively studied. Sweet marjoram (Origanum majorana L.), family Lamiaceae, is well known to be an herbaceous and perennial plant popular in southern Europe, north Africa, and southwest Asia that have strong antioxidant activity [8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Potential Impact of Marjoram on Coragen-Induced Physiological and Histological Alterations in Male Albino Rats

Hassan

Mohammed

Meligi

2021

Egyptian Journal of Zoology

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Oxidative damage and nephrotoxicity induced by prallethrin in rat and the protective effect of Origanum majorana essential oil

Abstract: We can conclude that prallethrin induced oxidative damage and renal toxicity in male rat. The administration of essential oil provided significant protection against prallethrin-induced oxidative stress, biochemical changes and histopathological damage.

Cited by 19 publications

References 23 publications

Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats

Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on Ischemia/Reperfusion-Induced Kidney Injury in Male Rats

DNA Damage and Expression Profile of Genes Associated with Nephrotoxicity Induced by Butralin and Ameliorating Effect of Arabic Gum in Female Rats

Potential Impact of Marjoram on Coragen-Induced Physiological and Histological Alterations in Male Albino Rats

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