Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties

Hadi, S. M.; Bhat, Ramesa Shafi; Azmi, Asfar S.; Hanif, Sarmad; Shamim, Uzma; Ullah, Mohammad Fahad

doi:10.1016/j.semcancer.2007.04.002

Cited by 229 publications

(183 citation statements)

References 48 publications

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“…[6][7][8][9] The polyphenolic compounds are generally not very active chemically and only electrostatic and hydrophobic forces are responsible for their interaction within cells. However, after oxidation of catechol and gallate 10 moieties to quinones ( Fig.…”

mentioning

confidence: 99%

Plant polyphenols in cell-cell interaction and communication

Tarahovsky

2008

Plant Signaling & Behavior

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Plant polyphenols including flavonoids and tannins are important constituent of our everyday diet and medical herbals. It is broadly accepted that polyphenols may protect us from toxins, carcinogens and pollutants though the mechanisms of the polyphenols action is still not clear. Here we discuss the ability of polyphenols and especially gallate rich compounds like tannins and catechin gallates to interact with proteins and lipids, establish binding between adjacent bilayer surfaces and initiate membrane aggregation. This phenomena discovered in model experiments could also influence lateral segregation and compartmentalization of cell surface compounds and assist the cell-cell interaction and signal transduction. The involvement of plant polyphenols in communication between cells could be an important factor responsible for anticarcinogenic, vascular and cardioprotective activity of these compounds and speculated to be implicated in the evolution of human brain and intelligence.Plant polyphenols including flavonoids and tannins are present on our daily diet. The opinion on their influence on the human health is contradictory and ranges widely from positive to skeptic and even to alarming. [1][2][3] Obviously the processes of their functioning in our body should be studied in more details.The polyphenols are know not only as patent antioxidants but also as cell metabolism regulators. 4 The biological functioning of these compounds begins from their interaction with the cell surface and penetration through the plasma membrane into the cytoplasm. They can influence various physical properties of membrane lipids including diffusion, melting temperature, detergent solubility, osmotic stability, permeability to water soluble compounds 5-7 and general parameters of lipid packing and intrinsic bilayer curvature related to membrane interaction and fusion. Their penetration through the lipid bilayer inversive correlates with the number of hydroxyl groups and accordingly with the hydrophobicity of molecules.The background of polyphenols functioning is attributed to the ability of these compounds to interact with proteins, lipids and polynucleotides through electrostatic, hydrophobic, and even covalent binding. [6][7][8][9] The polyphenolic compounds are generally not very active chemically and only electrostatic and hydrophobic forces are responsible for their interaction within cells. However, after oxidation of catechol and gallate 10 moieties to quinones (Fig. 1) in presence of peroxidases, polyphenol oxidases, alkaline pH, or transition metals they could be involved in reactions with free nucleophilic functional groups such as sulfhydryl, amine, amide, indole and imidazole substituents; 11 and result in covalent binding with different residues including lysine, methionine, cysteine and tryptophane. 8,12 We expect that terminal amino groups of phosphatidylethanolamines or sulfolipids of biological membranes can also participate in covalent binding with quinones. The consequence of chemical derivatization of proteins ma...

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confidence: 99%

Plant polyphenols in cell-cell interaction and communication

Tarahovsky

2008

Plant Signaling & Behavior

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“…For example, flavonol affects the function of aryl hydrocarbon receptors in cytoplasm (Mukai, et al 2010). In the nuclei of cancer cells, flavonols induce the oxidative cleavage of cellular DNA in the presence of copper ions and may therefore slow the progression of cancer growth (Hadi, et al 2007). In this chapter, we have shown that subcellular localization of flavonols varies between cell lines ( Fig.…”

Section: Discussionmentioning

confidence: 79%

Determination of Subcellular Localization of Flavonol in Cultured Cells by Laser Scanning

Mukai¹,

Terao²,

Shirai³

et al. 2011

Laser Scanning, Theory and Applications

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“…70,71 These SNMs are able to bind cell chromatin materials (both DNA and Cu[II]) forming a ternary complex. A redox reaction of the Se compound and Cu(II) in the ternary complex may occur, leading to the reduction of Cu(II) to Cu(I), whose …”

Section: Plausible Anticancer Mechanism Of Senrsmentioning

confidence: 99%

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

Ahmad¹,

Yasser²,

Sholkamy³

et al. 2015

IJN

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Selenium is an important component of human diet and a number of studies have declared its chemopreventive and therapeutic properties against cancer. However, very limited studies have been conducted about the properties of selenium nanostructured materials in comparison to other well-studied selenospecies. Here, we have shown that the anticancer property of biostabilized selenium nanorods (SeNrs) synthesized by applying a novel strain Ess_amA-1 of Streptomyces bikiniensis . The strain was grown aerobically with selenium dioxide and produced stable SeNrs with average particle size of 17 nm. The optical, structural, morphological, elemental, and functional characterizations of the SeNrs were carried out using techniques such as UV-vis spectrophotometry, transmission electron microscopy, energy dispersive X-ray spectrometry, and Fourier transform infrared spectrophotometry, respectively. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed that the biosynthesized SeNrs induces cell death of Hep-G2 and MCF-7 human cancer cells. The lethal dose (LD 50% ) of SeNrs on Hep-G2 and MCF-7 cells was recorded at 75.96 μg/mL and 61.86 μg/mL, respectively. It can be concluded that S. bikiniensis strain Ess_amA-1 could be used as renewable bioresources of biosynthesis of anticancer SeNrs. A hypothetical mechanism for anticancer activity of SeNrs is also proposed.

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Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties

Cited by 229 publications

References 48 publications

Plant polyphenols in cell-cell interaction and communication

Plant polyphenols in cell-cell interaction and communication

Determination of Subcellular Localization of Flavonol in Cultured Cells by Laser Scanning

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

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