Oxidative balance score and risk for incident prostate cancer in a prospective U.S. cohort study

Lakkur, Sindhu; Goodman, Michael; Bostick, Roberd M.; Citronberg, Jessica; McClellan, William M.; Flanders, W. Dana; Judd, Suzanne E.; Stevens, Victoria L.

doi:10.1016/j.annepidem.2014.02.015

Cited by 40 publications

(55 citation statements)

References 78 publications

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“…Our findings regarding the overall OBS‐adenoma association are consistent with those reported in previous epidemiologic studies, which found inverse associations of oxidative balance scores (OBS) with colorectal adenoma, prostate cancer, and total cancer mortality . Of direct relevance to the present study, in an analysis of three pooled case‐control studies of incident sporadic colorectal adenoma ( n = 789 incident adenoma cases and 1,500 polyp‐free controls), the odds ratio comparing those in the highest relative to the lowest OBS tertile was 0.54 (95%CI 0.43‐0.69; p trend < 0.0001) .…”

Section: Discussionsupporting

confidence: 91%

DNA base excision repair genetic risk scores, oxidative balance, and incident, sporadic colorectal adenoma

Wang

Goodman

Sun

et al. 2017

Molecular Carcinogenesis

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Associations of individual base excision repair (BER) genotypes with colorectal adenoma risk are unclear, but likely modest. However, genetic risk scores (GRS) that aggregate information from multiple genetic variants might be useful for assessing genetic predisposition to colorectal adenoma. We analyzed data pooled from three colonoscopy-based case-control studies of incident, sporadic colorectal adenoma (n = 488 cases, 604 controls) that collected blood for genotyping and extensive dietary and other data. We randomly split our population sample into training samples (half of the participants) and validation samples (the remaining participants) 10 times. Associations of 65 individual single nucleotide polymorphisms (SNPs) in 15 BER genes were assessed in the training samples and used to combine information from multiple risk variants into a BER GRS among the validation samples using unweighted and weighted methods. We also combined 15 extrinsic exposures with known pro- or antioxidant properties into an oxidative balance score (OBS). Associations of the BER GRS with colorectal adenoma, overall and jointly with the OBS, were assessed using multivariable logistic regression. The odds ratio for those in the highest relative to the lowest tertile of the weighted BER GRS was 2.07 (95% confidence interval, 1.26-3.40; p = 0.01). Relative to those with both a low GRS and a high (more antioxidant) OBS, the estimated direct association for those with both a high BER GRS and a low OBS was stronger than for those in other GRS/OBS categories. Our findings suggest that BER genotypes collectively may be associated with incident sporadic colorectal adenomas.

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Section: Discussionsupporting

confidence: 91%

DNA base excision repair genetic risk scores, oxidative balance, and incident, sporadic colorectal adenoma

Wang

Goodman

Sun

et al. 2017

Molecular Carcinogenesis

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“…48 OBS, measured by FFQs, has been used in a number of peer-reviewed publications. 16, 17, 19, 39 Similar associations were observed when OBS was measured by replacing questionnaire responses with biomarkers of pro- and antioxidant exposures. 37 …”

Section: Discussionmentioning

confidence: 54%

“…The purpose of OBS is to examine the balance of these modifiable factors; this approach has been used in a number of previous publications. 16, 17, 19, 39 In addition to extrinsic modifiable factors, oxidative stress is also influenced by intrinsic factors such as antioxidant enzymes and cellular energy balance; 49 These factors are not included in the OBS. Further, oxidative stress itself can be measured using a variety of biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…16, 17 Previous studies found that a higher OBS was associated with lower risk of colorectal adenoma 16, 18 and mortality, 17 but not prostate cancer, 19 indicating that the role of oxidative stress in human pathophysiology may be organ- or disease-specific. To better understand the specific roles of oxidative stress-modifying exposures in various health outcomes, the potential mechanisms represented by an OBS should be examined using biomarkers, which can act as upstream indicators of future health events.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress, inflammation, and markers of cardiovascular health

et al. 2015

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Objective To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein-(LDL)-cholesterol, high-density lipoprotein-(HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. Methods Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3–26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. Results The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38–0.66) for CRP, 0.50 (0.36–0.71) for the total WBC count, and 0.75 (0.58–0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. Conclusion Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.

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“…It is important to point out, however, that equal weighting approach is difficult to justify [20, 21]. Some previous studies assigned OBS weights based on the reported associations between individual OBS components and outcomes of interest such as colorectal tumors [22] and prostate cancer [23]; however no previous study used weighting based on biochemical measures of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Oxidative balance score as predictor of all-cause, cancer, and noncancer mortality in a biracial US cohort

Kong

Goodman

Judd

et al. 2015

Annals of Epidemiology

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Purpose We previously proposed an oxidative balance score (OBS) that combines pro- and anti-oxidant exposures to represent the overall oxidative balance status of an individual. In this study, we investigated associations of the OBS with all-cause and cause-specific mortality, and explored alternative OBS weighting methods in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study cohort. Methods The OBS was calculated by combining information from 14 a priori selected pro- and anti-oxidant factors, and then divided into quartiles with the lowest quartile (predominance of pro-oxidants) as reference. Cox proportional hazard models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for each OBS category compared to the reference. Results Over a median 5.8 years of follow-up, 2,079 of the 21,031 participants died. The multivariable adjusted HRs (95% CI) for all-cause, cancer, and non-cancer mortality for those in the highest vs. the lowest equal-weighting OBS quartile were: 0.70 (0.61, 0.81), 0.50 (0.37, 0.67), and 0.77 (0.66, 0.89), respectively (P-trend < 0.01 for all). Similar results were observed with all weighting methods. Conclusion These results suggest that individuals with a greater balance of anti-oxidant to pro-oxidant lifestyle exposures may have lower mortality.

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Oxidative balance score and risk for incident prostate cancer in a prospective U.S. cohort study

Cited by 40 publications

References 78 publications

DNA base excision repair genetic risk scores, oxidative balance, and incident, sporadic colorectal adenoma

DNA base excision repair genetic risk scores, oxidative balance, and incident, sporadic colorectal adenoma

Oxidative stress, inflammation, and markers of cardiovascular health

Oxidative balance score as predictor of all-cause, cancer, and noncancer mortality in a biracial US cohort

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