Oxidative stress, inflammation, and markers of cardiovascular health

Abstract

Objective To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein-(LDL)-cholesterol, high-density lipoprotein-(HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. Methods Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3–26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. Results The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38–0.66) for CRP, 0.50 (0.36–0.71) for the total WBC count, and 0.75 (0.58–0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. Conclusion Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.

Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

“…It is therefore possible that by administering large doses of NAC and glutathione, along with zinc, Vitamin C and Nrf2 activators, we lowered oxidative stress and inflammatory cytokine production, resulting in a rapid improvement in dyspnea and clinical symptomatology. A limitation of our study, apart from the small sample size however, is that we were unable to do laboratory testing in our patients, including checking oxidative stress markers (lipid peroxides) as well as inflammatory markers (CRP, ferritin, D-dimer) and LDH which might demonstrate a change post GSH administration [76][77][78]. A randomized, controlled trial of GSH, glutathione precursors with inflammatory/oxidative stress markers should be done in the future to fully elucidate the effects of blocking NF-kappaB, and to determine the effect of GSH and antioxidants on the clinical course of COVID-19 pneumonia and ARDS.…”

Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells

“…Excessive ROS accumulation disrupts tissue function and structure that induces chronic age‐related diseases . Furthermore, excessive ROS and chronic inflammation can cause mitochondrial damage . A previous report suggests that the promotion of mitochondrial biogenesis will enhance cell survival and recovery in aging‐induced disease .…”

Anti-inflammatory effects of proanthocyanidin-rich red rice extract via suppression of MAPK, AP-1 and NF-κB pathways in Raw 264.7 macrophages

“…Inflammation may be identified as the biological response to oxidative stress. Oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases, including cancer, atherosclerosis, and diabetes [ 14 15 ]. There is significant evidence indicating that LPS induced mediators of oxidative stress lead to generation of the production of ROS, which themselves induced cytokine production [ 16 17 ].…”