Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants

Lakkur, Sindhu; Bostick, Roberd M.; Roblin, Douglas W.; Ndirangu, Murugi; Okosun, Ike S.; Annor, Francis; Judd, Suzanne E.; Flanders, W. Dana; Stevens, Victoria L.; Goodman, Michael

doi:10.3109/1354750x.2014.937361

Cited by 31 publications

(35 citation statements)

References 52 publications

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“…Concentrations of inflammation markers were comparable to those in the pilot trial, which had a much shorter gap between sample collection and laboratory measurement (21). Most importantly, associations of these biomarkers at baseline with sex, body measurements, and an oxidative balance score were consistent with previous findings from our group (42,45,46) and other groups (e.g., refs. [47][48][49], supporting the validity of our biomarker measurements.…”

Section: Discussionsupporting

confidence: 86%

Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial

Yang

Gross

Fedirko

et al. 2015

Cancer Prevention Research

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Inflammation and oxidative stress play important roles in colorectal carcinogenesis. There is strong evidence that calcium reduces risk for colorectal neoplasms, possibly through its ability to bind bile acids and prevent their colonic toxicity (which occurs via an oxidative mechanism and results in an inflammatory response). In a previously reported pilot, randomized, controlled trial among sporadic colorectal adenoma patients we found that those on 2.0 g/day of calcium, relative to those on placebo, had an estimated drop in a combined cytokine z-score of 48% (P ¼ 0.18) over 6 months. To follow-up these promising preliminary findings, we tested the efficacy of two doses of supplemental calcium (1.0 or 2.0 g/day) relative to placebo on modulating circulating biomarkers of inflammation [C-reactive protein (CRP) and 10 cytokines] and oxidative stress (F 2 -isoprostanes) over a 4-month treatment period among 193 patients with previous sporadic, colorectal adenoma in a randomized, double-blinded, placebo-controlled clinical trial. The inflammation markers were measured in plasma using electrochemiluminescence detection-based immunoassays, and F 2 -isoprostanes were measured in plasma using gas chromatography-mass spectrometry. Over a 4-month treatment period, we found no appreciable effects of calcium on CRP, cytokines, or F 2 -isoprostanes (P > 0.4), overall or within strata of several major risk factors for colorectal carcinogenesis, such as body mass index and regular use of nonsteroidal anti-inflammatory drugs. Overall, our results provide no evidence that calcium supplementation favorably modulates concentrations of circulating biomarkers of inflammation or oxidative stress over 4 months among patients with a previous colorectal adenoma. Cancer Prev Res; 8(11); 1069-75.Ó2015 AACR.

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Section: Discussionsupporting

confidence: 86%

Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial

Yang

Gross

Fedirko

et al. 2015

Cancer Prevention Research

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“…However, this is unlikely, as a number of studies in different populations have observed similar associations. 38, 47 …”

Section: Discussionmentioning

confidence: 99%

Oxidative stress, inflammation, and markers of cardiovascular health

et al. 2015

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Objective To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein-(LDL)-cholesterol, high-density lipoprotein-(HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood cell [WBC] counts) among 19,825 participants in a nationwide study. Methods Using cross-sectional data 14 dietary and lifestyle components were incorporated into the OBS and the resulting score (range 3–26) was then divided into five equal intervals. Multivariable-adjusted odds ratios (ORs) for abnormal biomarker levels and 95% confidence intervals (CIs) were calculated using logistic regression models. Results The ORs (95% CIs) comparing those in the highest relative to those in the lowest OBS equal interval categories were 0.50 (0.38–0.66) for CRP, 0.50 (0.36–0.71) for the total WBC count, and 0.75 (0.58–0.98) for LDL-cholesterol; all three p-values for trend were <0.001. The OBS-HDL-cholesterol association was statistically significantly inverse among females, but not among males. The OBS was not associated with serum albumin or triglycerides. Conclusion Our findings suggest that an OBS may be associated with some, but not all, circulating lipids/lipoproteins and biomarkers of inflammation.

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“…The methods of the study have been described in detail elsewhere. 19 Briefly, the study included individuals aged 25–74 years who self-identified as Non-Hispanic Whites (NHW), African Americans (AA) or West African Immigrants (WAI) and who were residents of Georgia. NHW and AA subjects were selected from among 800 participants in a previously completed feasibility phase of the Georgia Cohort Study.…”

Section: Methodsmentioning

confidence: 99%

“…The OBS was estimated using a priori selected 13 pro-oxidant and antioxidant components according to our previous study 19 and those of others 27,28 as listed in Table 1. The score combined plasma micronutrient measurements and lifestyle behaviors.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have proposed oxidative balance score (OBS), a measure of the status of pro-oxidants and antioxidants, to be a more accurate representation of the overall OS-related exposures in an individual. 19,20 The present study therefore sought to build on and expand on the existing literature. The specific objectives of the present study were to examine: (1) the relationship between hypertension and each of four biomarkers of OS and (2) the association between hypertension and OBS.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress, oxidative balance score, and hypertension among a racially diverse population

Annor

Goodman

Okosun

et al. 2015

Journal of the American Society of Hypertension

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Hypertension is a risk factor for several vascular diseases. Evidence suggests that oxidative stress (OS) plays a significant role in its pathophysiology. Human studies have shown inconsistent results, varying based on the OS biomarker and study population. In a racially diverse population, examine the association between: (1) blood pressure or hypertension and four markers of OS and (2) blood pressure or hypertension and oxidative balance score (OBS). Using data (n = 317) from the cross-sectional study on race, stress, and hypertension, an OBS was constructed from various measures of pro-oxidant and antioxidant exposures. OS was assessed by four biomarkers: fluorescence oxidative products, F2-isoprostanes, mitochondrial DNA copy number, and gamma tocopherol. Multivariate linear and logistic regression analyses were used to estimate the associations of interest. None of the adjusted associations between hypertension and OS markers was statistically significant. OBS was inversely associated with hypertension after adjusting for study covariates. Persons with higher OBS have lower odds of having hypertension; however, the evidence on the relationship between OS markers and blood pressure remains unconvincing.

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Oxidative balance score and oxidative stress biomarkers in a study of Whites, African Americans, and African immigrants

Cited by 31 publications

References 52 publications

Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial

Effects of Calcium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Colorectal Adenoma Patients: A Randomized Controlled Trial

Oxidative stress, inflammation, and markers of cardiovascular health

Oxidative stress, oxidative balance score, and hypertension among a racially diverse population

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