Oxidative and apoptotic effects of lambda-cyhalothrin modulated by piperonyl butoxide in the liver of Oreochromis niloticus

Piner, Petek; Üner, Nevin

doi:10.1016/j.etap.2012.01.001

Cited by 49 publications

(17 citation statements)

References 39 publications

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“…In a study, reporting an increased activity of AChE and increased oxidative damage in rat cerebral cortex and hippocampus, Trevisan et al (2008) suggested the reduction of antioxidant protection as a possible alternative mechanism for malathion toxicity. Piner and Unerb (2012) showed that free-radical-mediated oxidation can destroy various biomolecules, whereas Noeman, Hala, and Amal (2011) proposed inhibition of enzymes by MDA cross linking. Thus, AChE could also be inhibited due to oxidative damage as well as the occupation of its active sites by pollutants including insecticides (El-Demerdash 2011).…”

Section: Discussionmentioning

confidence: 99%

Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Dar

Khan

Raina

et al. 2015

Toxicological & Environmental Chemistry

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The oxidative-stress-inducing potential of the pyrethroid, bifenthrin, in the brain of rats was evaluated following daily oral administration of 5.8 mg/kg body weight. Lipid peroxidation in the brain was increased, while the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione S-transferase decreased. The activity of acetylcholinesterase (AChE) in erythrocytes and brain also decreased. Bifenthrin induces severe oxidative stress in brain, and inhibits brain and erythrocyte AChE.

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Section: Discussionmentioning

confidence: 99%

Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Dar

Khan

Raina

et al. 2015

Toxicological & Environmental Chemistry

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“…A comparison of 96 h LC50 values of gamma- versus lambda-cyhalothrin revealed respective levels of 0.047 μ g L −1 versus 0.149 μ g L −1 in bluegill ( Lepomis macrochirus ), 0.111 μ g L −1 versus 0.214 μ g L −1 in rainbow trout ( Oncorhynchus mykiss ), 0.17 μ g L −1 versus 2.3 μ g L −1 in guppy ( Poecilia reticulata ), and 0.27 μ g L −1 versus 0.64 μ g L −1 in zebrafish [9]. The 96 h LC50 lambda-cyhalothrin value for carp was reported at 0.5 μ g L −1 [23], and the 96 h LC50 lambda-cyhalothrin value for juvenile Nile tilapia ( Oreochromis niloticus ) was 2.901 μ g L −1 [24]. Thus we may presume that toxicity of lambda-cyhalothrin to early life stages of common carp may not be as significant as our results using gamma-cyhalothrin.…”

Section: Discussionmentioning

confidence: 99%

“…An adaptive response was mounted by tGSH, GSH, and GSH-dependent enzymes. Oxidative stress is shown to upregulate GSH and GSH-related enzymes [24]. High levels of the antioxidant enzymes superoxide dismutase (SOD) and CAT followed exposure to cypermethrin in common carp.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cyhalothrin-Based Pesticide on Early Life Stages of Common Carp (Cyprinus carpioL.)

Richterová

Máchová

Stará

et al. 2014

BioMed Research International

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The effects of Nexide (a.i. gamma-cyhalothrin 60 g L−1) on cumulative mortality, growth indices, and ontogenetic development of embryos and larvae of common carp (Cyprinus carpio L.) were studied. Levels of oxidative stress parameters glutathione reductase (GR), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST), and lipid peroxidation were determined. Eggs of newly fertilised common carp were exposed to Nexide at concentrations 5, 25, 50, 100, and 250 μg L−1 (0.3, 1.5, 3, 6, and 15 μg L−1 gamma-cyhalothrin). All organisms exposed to concentrations higher than 50 μg L−1 died soon after hatching; at 25 μg L−1, 95% mortality was recorded. Larvae exposed to 5 μg L−1 showed significantly lower growth and retarded ontogenetic development compared to control. Histological examination of the livers of larvae from the exposed group revealed dystrophic changes. The value of detoxification enzyme GST of organisms from the exposed group was significantly higher compared to the control and the value of defensive enzyme GPx was significantly lower compared to the control. The results of our investigation confirmed that contamination of aquatic environment by pesticides containing cyhalothrin may impair growth and development of early life stages of carp and cause disbalance of defensive enzymes.

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“…Damage to the mem- brane is thus a menace to the viability of the cells. 11,34 In the present study, the adrenal glands were the most vulnerable organs and necrotic cortices were apparent in all LCTtreated groups.…”

Section: Parametersmentioning

confidence: 91%

Biochemical and histopathological changes in the kidney and adrenal gland of rats following repeated exposure to lambda-cyhalothrin

Oularbi

2014

J Xenobiotics

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Lambda-cyhalothrin (LCT) is a type II pyrethroid insecticide widely used in pest management. This study was undertaken to evaluate the toxic effects of LCT on the kidneys and adrenal glands of rats after subacute exposure. Twenty-eight 6-week-old male albino Rattus norvegicus rats were randomly assigned to four groups. Group 1 was the control group, which received distilled water. The experimental groups 2, 3 and 4 received 20.4, 30.6 and 61.2 mg/kg body weight, respectively, of LCT, administered orally over 28 days. The effects of the insecticide on various biochemical parameters were evaluated at 14 and 28 days. Histopathological studies were carried out in the kidneys and adrenal glands at the end of the experiment. Lambda-cyhalothrin, as a pyrethroid insecticide, induced significant increases (P 0.05) in plasma urea, creatinine, uric acid and glucose concentrations, and alanine aminotransferase and aspartate aminotransferase activities after 14 and 28 days. In the rat plasma samples after 28 days, residual concentrations of LCT 1R, cis, S cyhalothrin (1) and 1S, cis, R, cyhalothrin (2) were clearly detected. All experimental animals showed dose-dependent organ pathologies, such as necrotic degeneration of the adrenal glands and narrowed appearance of Bowman's space, degeneration of tubular epithelial lining, widened lumen, and tissue congestion in the kidney. It can be concluded that lambda cyhalothrin is highly toxic for rat adrenal glands and kidneys. ) for plasma lambda-cyhalothrin concentration determination and technical assistance in the setting up of GC-MS/MS conditions.

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Oxidative and apoptotic effects of lambda-cyhalothrin modulated by piperonyl butoxide in the liver of Oreochromis niloticus

Cited by 49 publications

References 39 publications

Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Effect of repeated oral administration of bifenthrin antioxidant status and acetylcholinesterase activity in brain of rats

Effects of Cyhalothrin-Based Pesticide on Early Life Stages of Common Carp (Cyprinus carpioL.)

Biochemical and histopathological changes in the kidney and adrenal gland of rats following repeated exposure to lambda-cyhalothrin

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