Oxidative and Antioxidative Stress Markers in Relation to Left Ventricular Dysfunction and Gender

Abstract

Objective The aim of this study was to investigate the relationship between oxidative and antioxidative stress markers with presence of left ventricular dysfunction (LVD) and the severity of LVD with coronary artery disease (CAD) in patients who have undergone percutaneous coronary intervention (PCI). Further, the role of oxidative and anti-oxidative stress markers on gender was also investigated. Methods This was an observational prospective pilot study of patients diagnosed with CAD with LVD who underwent PCI at the center from June 2017 to December 2017. Based on the ejection function (EF), patients were categorized into three groups: mild (> 40–50%), moderate (> 35–40%), and severe (≤ 35%). The oxidative and antioxidative stress markers (malondialdehyde [MDA], glutathione [GSH], and nitric oxide [NO]) were studied and compared in these groups and in both genders as subanalysis. Results Total 33 patients were enrolled, of whom 23 were male (69.7%) and 10 were female (30.3%). Mean age of the study population was 58.8 ± 9.3 years. Significant elevation of MDA and NO was seen in 33 (100%) and 26 (78.8%), respectively, and decreased GSH was seen in 30 (90.9%). There was no significant difference with respect to oxidative and antioxidative stress markers and severity of LVD (MDA, p = 0.25; NO, p = 0.79; and GSH, p = 0.2) despite elevated MDA levels in all patients. The subanalysis was done to see the gender effect with oxidative and antioxidative stress markers (MDA, p = 0.29; NO, p = 0.10; and GSH, p = 0.50), and they all were insignificant. Conclusion In this study, there was no significant relationship of oxidative and anti-oxidative stress markers on the degree of LVD even though the elevated MDA levels suggestive of increased oxidative stress were seen in all patients. The further analysis of gender in relation to oxidative and antioxidative stress markers was also insignificant.

Causal Role of Oxidants and Antioxidants in Atherosclerosis

“…In this issue, thte levels of oxidant/antioxidants in patients of acute coronary syndrome with left ventricular (LV) dysfunction who have undergone percutaneous intervention therapy and the correlation of oxidant and antioxidant levels with severity of LV dysfunction have been studied in an observational prospective study and are presented with the title "Oxidative and Anti-Oxidative Stress Markers in Relation to Left Ventricular dysfunction." 8 Elevated malondialdehyde (MDA) levels were observed with severity of LV dysfunction, but for further correlation, larger population with continuous follow-up over a period of several years needs to be done.…”