Oxidative albumin damage in chronic liver failure: Relation to albumin binding capacity, liver dysfunction and survival

Oettl, Karl; Birner‐Gruenberger, Ruth; Spindelboeck, Walter; Stueger, Hans Peter; Dorn, Livia; Stadlbauer, Vanessa; Putz-Bankuti, Csilla; Krisper, Peter; Graziadei, Ivo; Vogel, Wolfgang; Lackner, Carolin; Stauber, Rudolf

doi:10.1016/j.jhep.2013.06.013

Cited by 166 publications

(185 citation statements)

References 29 publications

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“…The chemical structure of HSA is susceptible to modification through enzymatic and non-enzymatic reactions including glycosylation, reversible and irreversible oxidation at the Cys-34 and other sites with emerging evidence that these structural changes are associated with altered biological functions ( Fig. 1) [2,14].…”

Section: Albumin Structurementioning

confidence: 99%

“…Although initially used in liver and other diseases as a plasma expander based on its oncotic function, it is now irrefutably clear that albumin has multiple other biologic properties including antioxidant, immunomodulatory and endothelial regulatory functions. Cirrhosis is associated not only with reduced albumin synthesis but also specific alterations to its structure and function such as posttranscriptional changes and oxidative damage, which have been associated with impaired function and clinical outcomes [1][2][3]. This has led to the concept of ''effective albumin concentration'' which provides insights into the contribution of HSA to clinical complications of cirrhosis [4].…”

Section: Introductionmentioning

confidence: 99%

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Albumin in chronic liver disease: structure, functions and therapeutic implications

2015

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Human serum albumin is a critical plasma protein produced by the liver with a number of accepted clinical indications in chronic liver disease including management of circulatory and renal dysfunction in patients with ascites. Advanced cirrhosis is characterised by reduced albumin concentration as well as impaired albumin function as a result of specific structural changes and oxidative damage. Traditionally, the biologic and therapeutic role of albumin in liver disease was attributed to its oncotic effects but it is now understood that albumin has a wide range of other important physiologic functions such as immunomodulation, endothelial stabilisation, antioxidant effects and binding multiple drugs, toxins and other molecules. This review discusses the multifunctional properties of albumin and, in particular, the biologic and clinical implications of structural and functional changes of albumin that are associated with cirrhosis. Based on these insights, we explore the current and potential future therapeutic uses of albumin in liver disease.

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Section: Albumin Structurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Albumin in chronic liver disease: structure, functions and therapeutic implications

2015

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“…Thus, albumin is the major protein among other plasma proteins produced by the liver. A number of recent studies have demonstrated possible depletion of albumin in plasma due to oxidative damage in cases of liver dysfunction/damage (Oettl et al 2008(Oettl et al , 2013Stauber et al 2014). Since urine is the glomerular filtration product of plasma in the kidney, depletion of albumin in urinary excretion, as observed in this study, could be linked to dysfunction/damage in albumin formation in the liver where 210 Po preferentially localizes.…”

Section: Discussionmentioning

confidence: 99%

A study on the effect of the internal exposure to 210Po on the excretion of urinary proteins in rats

Sadi

et al. 2016

Radiat Environ Biophys

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This study was designed to assess the feasibility of a noninvasive urine specimen for the detection of proteins as indicators of internal exposure to ionizing radiation. Three groups of rats (five in each group) were intravenously injected with 1601 ± 376, 10,846 ± 591 and 48,467 ± 2812 Bq of (210)Po in citrate form. A sham-exposed control group of five rats was intravenously injected with sterile physiological saline. Daily urine samples were collected over 4 days following injection. Purification and pre-concentration of urinary proteins were carried out by ultrafiltration using a 3000 Da molecular weight cutoff membrane filter. The concentration of common urinary proteins, namely albumin, alpha-1-acid glycoprotein, immunoglobulins IgA and IgG, was measured by an enzyme-linked immunosorbent assay. Urinary excretion of albumin decreased dose-dependently (p < 0.05) 96 h post-injection relative to the control group. In contrast, no statistically significant effects were observed for other proteins tested. The dose-dependent decrease in urinary excretion of albumin observed in this study underscores the need for further research, which may lead to the discovery of new biomarkers that would reflect the changes in the primary target organs for deposition of (210)Po.

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“…Dies ist aufgrund einer gestörten Bindungskapazität des Albumins durch vermehrte Bildung und/oder verminderte Bindung bzw. verminderte Inaktivierung dieser Substanzen bedingt und führt letztendlich zu einer zusätzlichen Beeinträchtigung der Nierenfunktion [11,16,30]. Die Albumindysfunktion spielt auch eine Rolle bei der hepatisch bedingten Einschränkung der myokardialen Kontraktilität [15] und damit auch bei der Entwicklung der Niereninsuffizienz.…”

Section: Lebererkrankung Kommt Es Zu Einer Vermehrten Aktivität Vasoaunclassified

Hepatorenales Syndrom bei dekompensierter Leberzirrhose

Lenz

Buder

Lohr

et al. 2016

Med Klin Intensivmed Notfmed

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Oxidative albumin damage in chronic liver failure: Relation to albumin binding capacity, liver dysfunction and survival

Cited by 166 publications

References 29 publications

Albumin in chronic liver disease: structure, functions and therapeutic implications

Albumin in chronic liver disease: structure, functions and therapeutic implications

A study on the effect of the internal exposure to 210Po on the excretion of urinary proteins in rats

Hepatorenales Syndrom bei dekompensierter Leberzirrhose

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