Hepatorenales Syndrom bei dekompensierter Leberzirrhose

Lenz, Kurt; Buder, R; Lohr, G; Piringer, P; Voglmayr, M

doi:10.1007/s00063-016-0177-5

Med Klin Intensivmed Notfmed

2016

DOI: 10.1007/s00063-016-0177-5

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Hepatorenales Syndrom bei dekompensierter Leberzirrhose

Kurt Lenz

R Buder

G Lohr

et al.

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Cited by 2 publications

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“…It is characterized by functional kidney disturbances resulting from renal artery vasoconstriction while maintaining tubular function without significant histologic changes. The primary cause of renal artery vasoconstriction in hepatorenal syndrome is splanchnic artery vasodilation, leading to a reduction in effective arterial pressure [9].…”

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Recurrent variceal bleeding in cirrhotic patients with acute kidney injury

Gomaa

Wahid²,

Qasem³

2022

Zagazig University Medical Journal

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Background: Patients with liver cirrhosis who present with bleeding esophageal varices are at a higher risk of developing acute kidney injury (AKI), which, in turn, has negative impacts and a poor prognosis. In our study, we aimed to determine the association between recurrent esophageal variceal bleeding and the presence of AKI in patients with liver cirrhosis. Methods: Our study included 203 cirrhotic patients, divided into two groups based on the absence or presence of AKI. All patients underwent a comprehensive medical history evaluation, clinical examination, and laboratory investigations. Treatment for all patients included fluid resuscitation, vasopressor agents, and endoscopic management. Both groups were closely monitored to assess the rate of esophageal variceal re-bleeding. Results: Out of the 203 patients, 91 (45%) developed AKI. Several factors, such as low systemic blood pressure, a high volume of blood transfusion, and a high Child-Pugh score, were identified as independent predictors for AKI. Factors such as Child-Pugh scores (p = 0.006), active bleeding observed during endoscopy (p = 0.04), and the occurrence of AKI (p = 0.049) were identified as independent predictors of variceal re-bleeding at both 72 hours and 1 month. Among patients with AKI, the variceal rebleeding rate was 27.5% at 72 hours, 16.5% at 1 month, and 12.1% at 3 months, compared to 9%, 5.4%, and 4.5%, r espectively, in patients without AKI. Within the first 72 hours, the rate of esophageal variceal re-bleeding was higher in patients with a more advanced stage of AKI. Conclusions: The incidence of recurrent esophageal variceal bleeding was significantly higher in patients with liver cirrhosis who developed AKI.

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confidence: 99%

Recurrent variceal bleeding in cirrhotic patients with acute kidney injury

Gomaa

Wahid²,

Qasem³

2022

Zagazig University Medical Journal

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Organinteraktion Leber und Niere

Roedl¹,

Jarczak²,

Fuhrmann³

2017

Dtsch med Wochenschr

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Alterations of the kidney function can be observed often in patients with liver diseases. Different mechanisms are leading to alterations in kidney funciton in these patients. New onset of kidney function alterations in patients with acute- or chronic liver disease often leads to acute kidney injury. This Review will inform you about the most importatant clinical interactions of the kidneys and the liver.

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Hepatorenales Syndrom bei dekompensierter Leberzirrhose

Cited by 2 publications

References 47 publications

Recurrent variceal bleeding in cirrhotic patients with acute kidney injury

Recurrent variceal bleeding in cirrhotic patients with acute kidney injury

Organinteraktion Leber und Niere

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