Oxidation potentials of platinum(II) bromide and iodide complexes

Salishcheva, O. V.; Tarasova, Yu. V.; Молдагулова, Н. Е.; Gel'fman, M. I.

doi:10.1134/s0036023606040097

Cited by 2 publications

(1 citation statement)

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“…The main fragmentation pathways involve the loss of HCl (product ion at m/z 423) and the formation of the [G+H] + ion at m/z 152. It is also worth noting that platinum‐DMSO complexes are very common 18–21…”

Section: Resultsmentioning

confidence: 99%

Electrospray ionization mass spectrometric study of purine base‐cisplatin complexes

Frańska

Frański

Schroeder

et al. 2005

Rapid Comm Mass Spectrometry

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By mixing cisplatin (cis-diamminedichloroplatinum(II)) with purine base the following ions have been obtained under electrospray ionization conditions: [A+Pt(NH3)2 Cl]+, [A+PtNH3Cl]+, [G+Pt(NH3)2 Cl]+ and [G+PtNH3)Cl]+. Their collision-induced dissociation led to the loss of NH3 and HCl and formation of the protonated base. The last process is strongly favoured for adenine over guanine. It confirms that, analogously as for DNA, formation of the guanine-cisplatin complex is favoured over that of the adenine complex and, as a consequence, it suggests that the mass spectrometric study of nucleic base complexes with platinum may provide some information on the interactions of DNA with other platinum drugs. The loss of NH3 accompanied by that of CO from the guanine ring has experimentally confirmed the presence of a strong hydrogen bond between the NH3 molecule and the O=C6 moiety of guanine found by theoretical calculations.

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Section: Resultsmentioning

confidence: 99%