Oxidation of low density lipoprotein in hemodialysis patients: effect of dialysis and comparison with matched controls

Westhuyzen, Justin; Saltissi, David; Healy, Helen

doi:10.1016/s0021-9150(96)06040-6

Cited by 36 publications

(26 citation statements)

References 38 publications

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“…Modification of LDL may involve the protein and/or the lipid moieties. The apolipoprotein of LDL, apoB, may be posttranslationally glycosylated or desialylated or may react with products of lipid peroxidation (30,31). In our study, oxLDL concentrations were significantly higher in chronic HD patients compared with PD patients, patients with CKD, and control subjects, suggesting a difference in degree of apoB oxidation in patients with ESRD and especially in chronic HD patients (32).…”

Section: Discussionmentioning

confidence: 99%

Oxidized Low-Density Lipoproteins Activate CD4+ T Cell Apoptosis in Patients with End-Stage Renal Disease through Fas Engagement

Meier¹,

Spertini

Blanc

et al. 2007

Journal of the American Society of Nephrology

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Oxidized LDL (oxLDL) are cytotoxic to vascular cells, but their possible toxic action on T cells from patients with ESRD has not been evaluated. oxLDL concentrations were measured and compared in patients who were on long-term hemodialysis (HD), in patients who had ESRD and were on continuous ambulatory peritoneal dialysis, in nondialyzed patients with chronic kidney disease, and in age-and gender-matched control subjects. In parallel, the proliferative capacity of CD69

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Section: Discussionmentioning

confidence: 99%

Oxidized Low-Density Lipoproteins Activate CD4+ T Cell Apoptosis in Patients with End-Stage Renal Disease through Fas Engagement

Meier¹,

Spertini

Blanc

et al. 2007

Journal of the American Society of Nephrology

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“…In our report and in accordance with most investigators, we did not demonstrate an increased susceptibility of uremic LDL to oxidation [27, 28, 29]. This is surprising, since patients had increased concentrations of small dense LDL known to be more prone to oxidation than large buoyant LDL.…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, Annuk et al [31]have recently reported that renal patients are in a state of oxidative stress compared with healthy controls. Differences in the observed findings may reflect a variety of confounding factors, including methodological procedures [27]. Additionally, dietary factors determining the fatty acid composition of LDL may play a role.…”

Section: Discussionmentioning

confidence: 99%

Compositional Lipoprotein Changes and Low-Density Lipoprotein Susceptibility to Oxidation in Chronic Renal Failure Patients with Heavy Proteinuria

Karabina

Pappas²,

Miltiadous³

et al. 2004

Nephron Clin Pract

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Background: There are limited data regarding qualitative lipoprotein abnormalities in undialysed uremic patients without proteinuria. In this report, we focused on lipoprotein changes observed in uremic patients with proteinuria as well as on the susceptibility of low-density lipoprotein (LDL) of these patients to oxidative modification in vitro. Methods: 20 patients with chronic renal failure [serum creatinine >1.6 mg/dl (141.4 µmol/l)], but not yet on renal replacement therapy, and with heavy proteinuria (>2 g/24 h), and 18 age- and sex-matched healthy individuals participated in the study. In both patients and controls, venous blood was collected for determination of serum lipid and lipoprotein levels, lipoprotein subfraction profile and chemical composition, as well as the susceptibility of LDL subfractions to oxidation. Results: Patients exhibited a more atherogenic lipid profile compared with the control population. Furthermore, the total very LDL + intermediate-density lipoprotein mass was increased in patients compared with controls, while this subfraction was triglyceride enriched in uremic patients. The total LDL concentration was significantly higher in patients compared with controls due mainly to an increase in the mass of all lipoprotein subfractions. It is noteworthy that the mass of small dense LDL was significantly elevated in patients compared with controls (135 ± 12 vs. 115 ± 11 mg/dl, p = 0.01), an increase which was more pronounced in hypertriglyceridemic patients. Furthermore, the subfraction high-density lipoprotein-2 mass was significantly lower in uremic patients compared with controls. Finally, no significant differences in the lag time, the rate of oxidation and the relative electrophoretic mobility values in each LDL subfraction between the two groups were observed. Conclusion: We conclude that uremic patients with heavy proteinuria exhibit compositional lipoprotein changes that are less marked than those observed in nonuremic patients with nephrotic syndrome. However, there is no evidence that circulating LDL isolated from these patients is more susceptible to oxidation in vitro than lipoprotein isolated from age- and gender-matched controls.

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“…Renal dysfunction is frequently associated with oxidative stress (19)(20)(21). It appears that ROS increase in a graded manner as renal function deteriorates, as different studies have reported inverse correlations between different markers of oxidative stress and glomerular fi ltration rate (22,66). It was postulated that lipid-induced tubulointerstitial disease might occur via oxygen radical generation.…”

Section: Discussionmentioning

confidence: 99%

High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue

Öztürk¹,

Özer²,

Billur³

et al. 2016

BLL

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Oxidation of low density lipoprotein in hemodialysis patients: effect of dialysis and comparison with matched controls

Cited by 36 publications

References 38 publications

Oxidized Low-Density Lipoproteins Activate CD4+ T Cell Apoptosis in Patients with End-Stage Renal Disease through Fas Engagement

Oxidized Low-Density Lipoproteins Activate CD4+ T Cell Apoptosis in Patients with End-Stage Renal Disease through Fas Engagement

Compositional Lipoprotein Changes and Low-Density Lipoprotein Susceptibility to Oxidation in Chronic Renal Failure Patients with Heavy Proteinuria

High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue

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