High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue

Öztürk, Bahadır; Özer, Özdemir; Billur, Deniz; Kızıl, Süleyman; Durak, Zahide Esra; Öztürk, Hasan Serdar

doi:10.4149/bll_2016_045

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…Furthermore, some studies in rabbits examined the effect of high cholesterol diets in rabbits and found a significant reduction in SOD [31,32] which is concordance to the results in this study. A study that showed an increase in MDA [32] in rabbits utilized dietary cholesterol at higher concentration in the diet compared to this study using 1% w/w in contrast to this study where 0.5% w/w was utilized.…”

Section: Hematoxylin and Eosin (A) Liver From Rabbit Fed Normal Chowsupporting

confidence: 91%

The Effect of Aqueous Extract of Vernonia Amygdalina (Bitter Leaf) on Antioxidants and the Liver of Rabbits on High Cholesterol Diet

Abdulmalik

Oladapo

2020

IJBcRR

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Aims: To determine the effect of V. amygdalina on the levels of antioxidants and the liver of rabbits fed on a atherogenic diet. Study Design: Prospective experimental study. Place and Duration of study: Study lasted 14 weeks at Department of Anatomy, University of Ibadan, Nigeria. Methodology: Eighteen male rabbits were randomly divided into three groups comprising control, high cholesterol diet and high cholesterol diet plus 200mg/kg of aqueous extract of V. amygdalina. The animals were fed a normal animal chow, or a diet supplemented by 0.5% cholesterol and 1% methionine for twelve weeks. Subsequently, serum was obtained for liver function tests. Samples of the liver of the animals were obtained for antioxidant tests and histology. Results: Aspartate transaminase was significantly elevated in atherogenic diet only group compared to animals on normal diet. There was also no statistically significant difference across the three groups in the alanine transaminase values. Superoxide dismutase were significantly reduced in animals that were administered extract. Malondialdehyde was not statistically different across the three groups. The histology of the liver of the animals on high cholesterol diet (with and without extract administration) revealed similar microscopic presence of fatty infiltration of the liver. Conclusion: The use of high cholesterol diet for a duration of twelve weeks in rabbits resulted in significant increased relative liver weight, aspartate transaminase, superoxide dismutase and hepatic microvesicular steatosis. Furthermore, the use of 200mg/kg of aqueous extract of V. amygdalina had ameliorative effect on the level of superoxide dismutase. It did not have a measurable effect on the malondialdehyde, liver enzymes and liver histology.

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Section: Hematoxylin and Eosin (A) Liver From Rabbit Fed Normal Chowsupporting

confidence: 91%

The Effect of Aqueous Extract of Vernonia Amygdalina (Bitter Leaf) on Antioxidants and the Liver of Rabbits on High Cholesterol Diet

Abdulmalik

Oladapo

2020

IJBcRR

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“…Endogenous defense mechanisms may lead to failure with overproduction of free radicals and consumption of antioxidants. MDA, an oxidation product of polyunsaturated fatty acids, was accepted as a proven marker of lipid peroxidation [24]. …”

Section: Discussionmentioning

confidence: 99%

Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues

Öztürk

Durak²,

Büber

et al. 2016

Scientifica

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Aim. To investigate the effects of static magnetic field (SMF) on oxidant and antioxidant parameters of the cancerous and noncancerous human gastric tissues. Materials and Methods. Gastric tissues obtained from patients with gastric cancer were used in the study. SMF was created by using two static magnets. Before and after treatment with SMF, oxidant and antioxidant parameters were measured in the tissue samples. Results. In the cancerous tissue, superoxide dismutase (SOD) activity was found higher and malondialdehyde (MDA) level was found lower as compared with noncancerous tissue. SMF affects oxidant/antioxidant parameters differently in the cancerous and noncancerous tissues. In this regard, SMF causes increase in SOD activity and decrease in MDA level in the noncancerous tissue. However, it decreases SOD and glutathione peroxidase (GSH-Px) activities and increases MDA level and catalase (CAT) activity in the cancerous tissue. There were no differences between nitric oxide (NO) and nitric oxide synthase (NOS) parameters in or among the cancerous and noncancerous tissues. Conclusions. SMF accelerates peroxidation reactions possibly by suppressing SOD and GSH-Px enzymes in the cancerous gastric tissue. This event caused by SMF might play part in the death of cancer cells, which may be a good supportive vehicle for the cancer therapy.

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“…Besides, the result of magnetic resonance imaging analysis in the kidneys of HCD-induced mice revealed renal dysfunction [ 49 ]. The increase in serum urea could be due to the consumption of HCD, which generates oxidant load and causes peroxidation, thereby leading to derangements in the rabbit kidney tissue [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits

Abd Rahim,

Mohd Kasim,

Omar

et al. 2024

PLoS ONE

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Previous research has shown that natural medications pose health risks, especially in subjects with comorbidities. This study aimed to evaluate the safety of saffron ethanolic extract (SEE) administration in early and established atherosclerotic rabbits. Rabbits were given a high-cholesterol diet (HCD) for 4 and 8 weeks to induce early and established atherosclerosis respectively, and then they were treated with 50 and 100 mg/kg/day SEE. The body weight of the animals was recorded. Blood samples were collected at baseline, pre-treatment, and post-treatment for hematological studies, lipid profiles, and biochemical profiles. Tissue specimens of the vital organs were subjected to histological examination. The above parameters were significantly altered post-intervention with 4 and 8 weeks of HCD. No significant differences in body weight were observed in all the groups post-treatment with 50 and 100mg/kg of SEE compared to pre-treatment. However, low-density lipoprotein cholesterol, total cholesterol, serum urea, and glucose significantly decreased post-treatment with 50 and 100mg/kg/day SEE compared to pre-treatment in early and established atherosclerosis groups. Hematological parameters that were affected post-intervention with HCD returned to their baseline values post-treatment with 50 and 100mg/kg/day SEE. There was a significant improvement in the vital organs post-treatment with 50 and 100mg/kg SEE. SEE can safely be administered without causing harmful effects on the hematological, biochemical profiles, and vital organs. Notably, SEE exerts hypolipidemic and hypoglycemic effects on atherosclerotic conditions. Further clinical trials are warranted to ensure the safety of saffron administration in patients with atherosclerosis-related diseases.

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High cholesterol diet leads to oxidant load and peroxidation in the rabbit kidney tissue

Abstract: OBJECTIVES: The aim of this study was to investigate possible effects of high cholesterol diet on oxidant/antioxidant status in rabbit kidney tissues.

Cited by 3 publications

References 52 publications

The Effect of Aqueous Extract of Vernonia Amygdalina (Bitter Leaf) on Antioxidants and the Liver of Rabbits on High Cholesterol Diet

The Effect of Aqueous Extract of Vernonia Amygdalina (Bitter Leaf) on Antioxidants and the Liver of Rabbits on High Cholesterol Diet

Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues

Safety evaluation of saffron extracts in early and established atherosclerotic New Zealand white rabbits

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