Oxidation of human red blood cells by a free radical initiator: Effects on rheological properties

Mazzulla, S.; Schella, Anita; Gabriele, Domenico; Baldino, Noemi; Sesti, Settimio; Perrotta, E.; Costabile, Adele; Cindio, Bruno de

doi:10.3233/ch-141841

Cited by 15 publications

(11 citation statements)

References 16 publications

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“…The ideal composition and stability of the plasma membrane, which is comprised mostly of phospholipids, is crucial to maintain RBC integrity. 22 The lipids that correlate positively with hemolysis in our study are mostly saturated lipids. Due to their structure, saturated lipids increase the rigidity of RBC membranes in which they are incorporated.…”

Section: Discussionmentioning

confidence: 51%

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The heritability of hemolysis in stored human red blood cells

et al. 2015

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Background The transfusion of red blood cells (RBCs) with maximum therapeutic efficacy is a major goal in transfusion medicine. One of the criteria used in determining stored RBC quality is end of storage hemolysis. Between donors, a wide range of hemolysis is observed under identical storage conditions. Here, a potential mechanism for this wide range is investigated. We hypothesize that the magnitude of hemolysis is a heritable trait. Also, we investigated correlations between hemolysis and RBC metabolites; this will establish pathways influencing hemolysis as future targets for genetic analysis. Study Design and Methods Units of RBCs from identical and non-identical twins were collected and stored under standard conditions for 56 days. Hemolysis, ATP, and total glutathione were measured throughout storage. Non-targeted metabolic analyses were performed on RBCs that had been stored for 28 days. Heritability was determined by comparing values between identical and non-identical twins. Results Hemolysis was found to be heritable (mean >45 %) throughout the storage period. Correlations were observed between hemolysis and metabolites from the amino acid, sugar, and purine metabolism, lipid metabolism and transport, and glycolysis pathways. Three metabolites also exhibited heritability (> 20%). No correlation was found with ATP or total glutathione. Conclusion The susceptibility of RBCs to lysis during storage is partly determined by inheritance. We have also uncovered several pathways that are candidate targets for future genome wide association studies. These findings will aid in the design of better storage solutions and the development of donor screening tools that minimize hemolysis during storage.

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Section: Discussionmentioning

confidence: 51%

“…It is not surprising to find a correlation between hemolysis and lipid metabolism and transport. The ideal composition and stability of the plasma membrane, which is composed mostly of phospholipids, is crucial to maintain RBC integrity . The lipids that correlate positively with hemolysis in our study are mostly saturated lipids.…”

Section: Discussionmentioning

confidence: 92%

The heritability of hemolysis in stored human red blood cells

et al. 2015

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“…In agreement to our study, a large body of research demonstrates that poor sleep quality affects psychomotor abilities (Ellis, Walczyk, Buboltz, & Felix, 2014), so, Its highly expected that each intervention that is capable of sleep improvement, can increase the attention and concentration. One of the possible mechanisms for improvement of psychomotor performance in training group may be due to augmentation of oxygen uptake, inhibition of vascular inflammatory processes, Rheological alterations in blood (Mazzulla et al, 2015). Gorelick et al (2011) reported that regular strength exercises promote vascularization in the body and enhance essential nutrient supply to the brain.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Strength Training on Quality of Sleep and Psychomotor Performance in Elderly Males

Irandoust¹,

Taheri²

2017

Sleep Hypn

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Based on the scientific evidences, aging process results in neurodegenerative processes with substantial loss of sensory, auditory, and vision which can affect the quality of sleep and psychomotor performance (Terpening et al., 2015). Problems with sleep tend to increase with aging. Research indicates that nearly 67% of the elderly people have at least one sleep-related complaint (Foley, Ancoli-Israel, Britz, & Walsh, 2004). According to the previous studies, those older people with regular strength training have more success in doing their daily lives, including personal works and independency (Arnold & Bautmans, 2014). In a study, Kirk-Sanchez and Mc Gough (2014) reported that regular physical activity in aged people, not only affects the physiological/metabolic pathways positively, but also lead to neuroprotective advantageous, and cognitive improvement (Kirk-Sanchez & McGough, 2014). Babaei (2013), Gorelick et al (2011) suggested that that strength exercises improve the cognitive capacities in older people (Babaei, Azali Alamdari, Soltani Tehrani, & Damirchi, 2013; Gorelick et al., 2011). Studies have shown that exercise, under certain conditions, may have

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“…Oxidative stress had been established as one of the principal causative factors of haematological disorders which include destructions of blood cells leading to secondary complications such as anaemia, leukaemia and thrombocytopenia [1,2]. Moreover, impairment in the functions of endogenous antioxidant systems are known to contribute to the elevation of free radicals and reactive oxygen species leading to oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Rich on haematological and biochemical parameters in healthy Wistar rats

Oso¹,

Oyewo

Oladiji

2019

Clin Phytosci

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Background: Bioactivities of plant-based compounds had been shown to be influenced by properties of the extracting solvents. This study investigated the influence of ethanolic extract of Xylopia aethiopica (Dunal) A. Rich on the haematological and biochemical parameters in apparently healthy Wistar Rats using solvent partitioning. Methods: The procedures involved partitioning of ethanolic extract of X. aethiopica (Dunal) A. Rich into n-hexane and aqueous fractions, chosen based on their differences in polarities and dielectric constants. The samples were administered at doses of 100 mg/kg body weight and 200 mg/kg body weight orally once per day for a period of fourteen (14) days to apparently healthy male Wistar rats that had been randomly selected into seven (7) groups. Haematological parameters and plasma biochemical indices were determined using standard protocols after the rats were sacrificed on the 15th day. Results: The results showed that the levels of haematocrit and related parameters in all the groups that received the extract when compared to the control increased significantly (p < 0.05). Additionally, no detrimental effect was observed on the levels of endogenous antioxidants, liver and kidney function indices in the rats compared to the control. Conclusion: In summary, on the basis of these findings, this study suggests that the extracts may be capable to alleviate the pathologies that are associated with haematological disorders through improvement of endogenous antioxidant status. The study proposes further evaluation on the molecular mechanism of bioactive components of X. aethiopica (Dunal) A. Rich as agents that can prevents anaemia.

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Oxidation of human red blood cells by a free radical initiator: Effects on rheological properties

Cited by 15 publications

References 16 publications

The heritability of hemolysis in stored human red blood cells

The heritability of hemolysis in stored human red blood cells

The Effect of Strength Training on Quality of Sleep and Psychomotor Performance in Elderly Males

Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Rich on haematological and biochemical parameters in healthy Wistar rats

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