Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives

Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)

“…It was reported that para-position is favour of biological activity 30,74,75 . Many studies have demonstrated that the inhibition of CA II is due to the ability of an inhibitor to mimic the tetrahedral transition state when binding to the catalytic Zn 2+ located in the active site 1,4,19,71 . The physiologically dominant cytosolic isoform hCA II is ubiquitous and is being involved in several diseases, such as epilepsy, edema, glaucoma and altitude sickness 76 .…”

“…Carbonic anhydrase (CA; EC 4.2.1.1) catalyses the simple but crucial reaction between carbon dioxide (CO 2 ) and water, leading to the formation of protons (H + ) and bicarbonate (HCO À 3 ) [1][2][3][4] . These enzymes are common to all organisms, from the very simple to complex.…”

Synthesis of N-alkyl (aril)-tetra pyrimidine thiones and investigation of their human carbonic anhydrase I and II inhibitory effects

“…[33][34][35][36][37] . Two cytosolic human CA isoforms (hCA I, and II) are widespread throughout the human body and are drug targets for clinically used diuretics, anticonvulsants and antiglaucoma drugs [38][39][40][41][42] . Five of the vertebrate CA isoforms are cytosolic (CA I, II, III, VII and XIII), some others (CA IV, IX, XII, XIV and XV) are membrane bound, two isoenzymes (CA VA and VB) are mitochondrial, and one isoform (CA VI) is secreted in saliva [43][44][45][46][47][48] .…”

Synthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase

“…Carbonic anhydrases are mainly Zn 2+ containing metalloenzymes that catalyze the reversible interconversion of CO 2 and H 2 O to HCO 3 À and a proton (H + ) for the hydration reaction or consumes one equivalent of H + for the dehydration reaction [15][16][17][18][19][20] . This makes these isoenzymes crucial for many physiological and biochemical processes including electrolyte secretion, respiration, pH and CO 2 homeostasis, bone calcification, ureagenesis, gluconeogenesis, tumorigenicity, lipogenesis, transport of CO 2 / HCO 3 À between metabolizing tissues and the lungs, and some other physiologic or pathologic processes [21][22][23][24][25] . This enzyme class is present either in eukaryote or prokaryote cells.…”