Keywords: Three-component condensation; Thiourea; Diethyl malonate; Tetra(hexa)hydro-pyrimidines
IntroductionThe need for the new researches for raising the efficiency of in the development of the petrochemical and medical industry is noticeable. Especially, there is a specific fundamental and applicable issue in science that the approach on a scientific direction in their solution does not justify itself and is not achieved satisfactory results for many years. The need for a complex scientific approach arises for such issues and the most successful scientific results of recent years are found in the research of the intersection of science with the multidisciplinary approach. From this point of view, as a result of the most recent studies conducted in the Institute of Chemistry of Additives of the Azerbaijan National Academy of Sciences, it was determined that, biocide additives synthesized at the institute shows biological (physiological) activity in other areas too, in addition to protect the oil products from the microbiological damage. For instance, amino ethanol and some derivatives of amino alcohols synthesized by the employees of Institute shows the properties of anesthetic and terminal anesthesia for the mucous membranes of the eye. The studies were conducted at the first Moscow State Medical Institute named after Sechenov IM. These substances are 7 times greater compared to the widely-used "xycain", according to its activity. As a result of investigations carried out, in the "Biochemical Pharmacology" Laboratory (Moscow oblast, Kupavna settlement) of Scientific Research Institute for the "Biological Testing" of chemical compounds, their antialcohol properties have been also identified.Bacteriological influence of heteroaryl sulfamides containing pyrimidine and pyrazole was investigated in the Microbiology department of Baku State University, and it was determined that, these substances quickly perishes the "stafilococ", "penicillium" and "mold" mushrooms in the concentration of 0,05-0,1%. 3 (beta-hydroxy (oxymethylene)-ethyl-1,3-oxazolidine (was named as "Cyclazole") has a high disinfectant propertiesand its usage was allowed by the Ministry of Health of the Republic of Azerbaijan. In other words, as a result of tests conducted at the Institute for Scientific Research of Virology, Microbiology, it was determined that the nitrogenous derivatives of alkylphenol and alkylaromatic ketones have the highest disinfectant and antiseptic properties and was advised to apply.When it comes to the use of these compounds in the oil and chemical industry, it should be noted that, many industrial materials, including the oil products are damaged with microorganisms when they are maintained and their exploitation conditions are violated (the highest humidity and temperature). Microorganisms affects negatively to the composition, properties and quality of these damaged materials, by adopting the hydrocarbons of petroleum products, as a source of food and energy and as well as affecting them by the metabolic products. Bec...