Oxidation events and skin aging

Kammeyer, Arthur; Luiten, Rosalie M.

doi:10.1016/j.arr.2015.01.001

Cited by 693 publications

(641 citation statements)

References 144 publications

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“…However, due to environmental stress, elevated ROS levels can overwhelm endogenous cellular antioxidant mechanisms [77]. This can lead to an imbalance in tissue oxygen homeostasis, with oxidant effects outweighing antioxidant effects, and, therefore, the cellular environment becomes oxidatively stressed [77]. Oxidation of lipids by ROS can damage cellular structures and result in premature cell death [78].…”

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

“…Antioxidants are generally produced to counteract the oxidative stress. However, due to environmental stress, elevated ROS levels can overwhelm endogenous cellular antioxidant mechanisms [77]. This can lead to an imbalance in tissue oxygen homeostasis, with oxidant effects outweighing antioxidant effects, and, therefore, the cellular environment becomes oxidatively stressed [77].…”

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

See 1 more Smart Citation

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant¹

2018

Cosmetics

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Abstract:Pollution from air and sunlight has adverse effects on human health, particularly skin health. It creates oxidative stress, which results in skin diseases, including skin cancer and aging. Different types of antioxidants are used as preventative actives in skin-care products. However, they have some limitations as they also scavenge oxygen. Recently, spin traps are being explored to trap free radicals before these radicals generating more free radicals (cascading effect) and not the oxygen molecules. However, not all spin traps can be used in the topical cosmetic skin-care products due to their toxicity and regulatory issues. The present review focuses on the different pathways of reactive oxygen species (ROS) generation due to pollution and the potential use of spin traps in anti-pollution cosmetics to control ROS.

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Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

Section: Pollution and Its Effect On The Skinmentioning

confidence: 99%

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Sawant¹

2018

Cosmetics

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“…This is normally referred to as photoaging, due to the importance of such health care [20]. UV radiation, particularly UVB, is most responsible for direct damage, reaching not only the stratum corneum, but also viable epidermal cells [23]. This way, measures that retard the …”

Section: Antiagingmentioning

confidence: 99%

“…The main component of the dermis is the extracellular matrix in the connective tissue. The connective tissue is produced by fibroblasts and is composed of three major classes of biomolecules: glucosaminoglycans (GAGs), proteoglycans, structural proteins (collagen and elastin), and special macromolecules (fibrillin, fibronectin, laminin, and hyaluronan) [23].…”

Section: Skinmentioning

confidence: 99%

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

Tedesco¹,

Jesus²

2017

Photomedicine - Advances in Clinical Practice

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Skin is the largest human organ and displays multiple functions involving structure and protection against external agents that may affect the body. Solar radiation accelerates the normal aging process and may even cause great damage leading to many different cutaneous diseases and skin cancer. Moreover, a wound in the skin may be an open channel for the access of pathogens usually exposing blood vessels for infections and causing serious complications. For many reasons, regulatory skin processes are of great deal in different approaches: basic antiaging, wound healing, and skin cancer. In a good way, photoprocesses with specific wavelength at low energy levels associated with photoactive compounds are known to cause the opposite effect, promoting the healing of cutaneous diseases and leading to well-defined outcomes in rejuvenation and antiaging. This chapter will discuss the most relevant topics in photo skin regeneration using low energy levels associated with photodynamic therapy (PDT), which emerged as a combination to potentialize molecules with the already known effects of PDT and low level laser therapy (LLLT) in the treatment of skin pathologies, known as a photobiomodulation process.

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“…Skin is exposed daily to extrinsic factors that directly or indirectly cause the generation of free radicals. Oxidative stress plays a key role in skin aging and causes damage on the epidermis and dermis layers [2]. Both the intrinsic and extrinsic aging processes are associated with structural, functional and mechanical skin changes: the loss of tissue, the formation of wrinkles, skin dryness, roughness, yellowness, dyspigmentation and low elasticity [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

Grand-Vincent¹,

Boisnic²,

Salomon³

et al. 2017

JCDSA

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Mesotherapy is a mildly invasive procedure involving several subcutaneous drug injections, which are performed simultaneously. The concept is to inject a very small amount of active compounds (hyaluronic acid, vitamins, antioxidants, enzymes, humectants, …) and the aim is to stimulate the biosynthetic capacity of fibroblasts, increase collagen and elastin production and to give active essential molecules for a fibroblasts environment. Numerous studies suggest that the mesotherapy procedure improves skin hydration and mechanical properties; however, some results have not been statistically significant. In this study, we investigated an antiaging treatment as a complementary approach to a non-surgical rejuvenating procedure after 5 sessions of mesotherapy. Our main objective was to assess the improvement of face, neck and neckline skin quality, after intradermal microinjections of NCTF 135HA®. This mixture, manufactured by FILORGA Laboratories, includes a non-cross-linked hyaluronic acid, vitamins, antioxidants, mineral salts and enzymes. A statistically significant decrease in the depth of crow's-feet wrinkles (43.3%) and in pore size (58.5%) was observed. Also, dermatological scores showed a significant decrease, and data suggest that skin tone was improved with a brighter tone. The injected mixture could then have an action on the skin pigmentation process with a photoprotective effect. Evolution of Dermis density was also investigated and an increase of dermal density and thickness were highlighted, showing an improvement of skin firmness with significant increases of dermis thickness (20%) and dermis density (24%), indicating a neocollagen activity.

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Oxidation events and skin aging

Cited by 693 publications

References 144 publications

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Potential Use of Spin Traps to Control ROS in Antipollution Cosmetics—A Review

Low Level Energy Photodynamic Therapy for Skin Processes and Regeneration

Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

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