Oxidant‐Antioxidant Status in the Blood of Horses with Symptomatic Recurrent Airway Obstruction (<scp>RAO</scp>)

Niedźwiedź, Artur; Jaworski, Zbigniew

doi:10.1111/jvim.12452

Cited by 16 publications

(16 citation statements)

References 36 publications

(105 reference statements)

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“…GSH-Px reacts with oxidants such as hydrogen peroxide and lipid hydroperoxides produced in the membrane (16,22). It is believed that hydrogen peroxide, which cannot be neutralized, is increased on the membrane surface as a result of decreased GSH-Px activity (24,25). Besides, it was determined that MDA concentration, which is a marker of lipid peroxidation, was significantly higher in the dogs with non-regenerative anemia.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of oxidative status in dogs with anemia

Gültekin

Voyvoda

2017

Medycyna Weterynaryjna

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SummaryThe aim of the present study was to evaluate the relationship between the oxidative status and the severity and type of anemia in dogs. A total of 70 dogs of various breeds, ages and of both sexes were enrolled in the study. Fifty dogs with anemia were classified according to the severity of anemia as mildly (n = 18), moderately (n = 18) or severely (n = 14) anemic on the basis of the hematocrit (HCT) value. Anemia in the same dogs was also classified according to the type as regenerative (n = 26) or non-regenerative (n = 24) on the basis of the absolute reticulocyte count. Twenty dogs were used as healthy control. Total oxidant status (TOS), total antioxidant capacity (TAC) and malondialdehyde (MDA) values in plasma as well as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in erythrocyte hemolysate were measured to evaluate the oxidative status. The plasma TOS value was increased in all anemic dogs, irrespective of the severity of anemia, whereas a significant increase in the TAC value and a significant decrease in erythrocyte GSH-Px activity were observed in mild and moderate anemia. Plasma TOS and TAC values were higher in dogs with both types of anemia when compared to the healthy group. A significant increase in plasma MDA concentration and a significant decrease in GSH-Px activity were observed in the non-regenerative anemia group. There were moderate negative correlations between HCT and TOS values in the mild anemia group and between HCT and erythrocyte GSH-Px activity in the regenerative anemia group. In conclusion, oxidative stress develops in dogs with anemia, and it is largely independent of the severity and type of anemia. These results suggest that further studies with different etiologies may also be useful for evaluating the efficacy of antioxidants administered at different doses and in different combinations to treat anemia in dogs.

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Section: Resultsmentioning

confidence: 99%

Evaluation of oxidative status in dogs with anemia

Gültekin

Voyvoda

2017

Medycyna Weterynaryjna

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“…In another study though, increased TNF-a concentrations were found after ex vivo stimulation with bacterial products in RAO affected horses (Lavoie-Lamoureux et al 2012b). Niedzwiedz et al (2011) found increased markers for oxidative stress in peripheral blood during exacerbation compared to controls.…”

Section: Systemic Inflammatory Markers In the Bloodmentioning

confidence: 90%

Diagnostic value of inflammatory markers in chronic respiratory disease of the horse – a review

Barton¹,

Shety²,

Wirth³

et al. 2014

PHK

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Summary: Over the last years local and systemic inflammatory markers of chronic pneumopathies have gained increasing interest in research, as the pathogenesis of Recurrent airway obstruction (RAO) and Inflammatory airway disease (IAD) remains not fully elucidated in several details. In human medicine, Asthma bronchiale and Chronic obstructive pulmonary disease (COPD) have been found to be influenced by systemic inflammatory processes and the other way around. Inflammation, coagulation and fibrinolysis as well as extracellular remodeling show close interactions. Cytology of bronchoalveolar lavage fluid and tracheal wash is commonly used to evaluate the severity of local inflammation in the lung. Interleukins involved in the chemotaxis of neutrophils like Interleukin 8, 17 and 23 have been studied. Chronic obstructive pneumopathies lead to remodeling of bronchial walls and lung parenchyma, ultimately causing fibrosis. Matrix-metalloproteinases (MMPs) are discussed as the most important proteolytic enzymes during remodeling in human medicine. In the horse, MMP 9 seems to be a central player in chronic respiratory disease as well. A systemic involvement has been shown for RAO by increased acute-phaseproteins like serumamyloid A and haptoglobin in peripheral blood during exacerbation. Studies focusing on these and further possible inflammatory markers for chronic respiratory disease in the horse are discussed in this review of literature.Keywords: Inflammatory markers / horse / respiratory disease / recurrent airway obstruction / RAO / Diagnostischer Wert verschiedener Entzündungsmarker bei chronischen Atemwegserkrankungen des Pferdes -eine ÜbersichtIn den letzten Jahren häufen sich Untersuchungen zu verschiedenen lokalen und systemischen Entzündungsmarkern bei chronischen Pneumopathien des Pferdes, da das Verständnis der Pathogenese von Recurrent airway obstruction (RAO) und Inflammatory airway disease (IAD) weiterhin nicht vollständig geklärt ist. Ein Blick in die Humanmedizin zeigt, dass das Asthma bronchiale und die Chronic obstructive pulmonary disease (COPD) durchaus in Zusammenhang stehen mit systemischen inflammatorischen Prozessen, so dass sich die lokalen Prozesse in der Lunge und systemische Entzündungsreaktionen gegenseitig beinflussen. Entzündung, Koagulation und Fibrinolyse sowie das extrazelluläre Remodelling sind eng miteinander verknüft. Zytologische Untersuchungen der bronchoalveolären Lavageflüssigkeit und des Tracheobronchialsekrets stellen die gebräuchlichste Methode dar, den Schweregrad der lokalen Entzündung zu beurteilen. Hierbei ergeben sich Zusammenhänge zu Interleukinen, die an der Chemotaxis neutrophiler Granulozyten beteiligt sind, wie beispielsweise Interleukin 8, 17 und 23. Chronisch obstruktive Pneumopathien führen langfristig zu chronischen Umbauprozessen der Bronchienwände und des Lungenparenchyms (Remodelling), die mit der Bildung von Fibrosen einhergehen. Matrix-Metalloproteinasen (MMPs) gelten in der Humanmedizin als wichtigste proteolytische Enzyme bei diesem Remodelling und auch...

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“…Antioxidant enzymes in horse pathology have been described, among others, in the course of oxidative stress following (62,63). Authors compare enzyme activity in a group of horses with RAO and those clinically healthy (64). The results of these studies showed a significantly impaired activity of antioxidant enzymes in horses with clinical form of RAO.…”

Section: The Enzyme Triad In Raomentioning

confidence: 99%

“…This condition indicates intensified formation of free radicals and their active participation in the pathogenesis of recurrent airway obstruction. Some studies showed a statistically significant increase in the activity of antioxidant enzymes in ill horses, while other studies showed a decrease in activity of these enzymes (18,22). Inconsistent results may be associated with the exacerbation of symptoms, horse maintenance or any treatment administered (1).…”

Section: The Enzyme Triad In Raomentioning

confidence: 99%

“…Results from these studies are difficult to compare because of differences in methodologies used and type of biomarker investigated. Despite the diversity of research models, namely exposing animals to allergens or factors having a negative impact on the body or subjecting them to stress tests, the studies did not allow for an in-depth analysis of the body's response to the negative effects of oxidative stress in RAO (16,17,18).…”

Section: Introductionmentioning

confidence: 99%

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Impact of Recurrent Airway Obstruction (RAO) on Selected Antioxidants in Horses

Borowicz

Kubiak

Nikolovski³

et al. 2016

Macedonian Veterinary Review

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The aim of this review was to collect the most important data on the characteristics of selected antioxidants in horses with recurrent airway obstruction (RAO). RAO is one of the most common respiratory diseases in horses. This disease can not be cured, but we can try to stop its progression. It is not exactly known, what is the real contribution of antioxidants in the pathology of recurrent airway obstruction. Many researchers investigated the possibility of using antioxidant supplementation in horses with RAO.

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Oxidant‐Antioxidant Status in the Blood of Horses with Symptomatic Recurrent Airway Obstruction (RAO)

Cited by 16 publications

References 36 publications

Evaluation of oxidative status in dogs with anemia

Evaluation of oxidative status in dogs with anemia

Diagnostic value of inflammatory markers in chronic respiratory disease of the horse – a review

Impact of Recurrent Airway Obstruction (RAO) on Selected Antioxidants in Horses

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