Oxidant–Antioxidant Balance in Patients with COPD

Hanta, İsmail; Kocabaş, Ali; Canacankatan, Necmiye; Kuleci, Sedat; Seydaoğlu, Gülşah

doi:10.1007/s00408-005-2561-4

Cited by 46 publications

(37 citation statements)

References 16 publications

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“…The failure to demonstrate significant differences in erythrocyte SOD activity between current smokers and ex-smokers in the present study, and between life-long nonsmokers and ever smokers in a previous study [16], are consistent with another published report [23]. The present findings suggest that COPD patients do not show altered erythrocyte SOD activity, contrary to the findings of previous studies [23,24] but in agreement with more recent reports [25,26].…”

Section: Discussionsupporting

confidence: 92%

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Mak

Ho²,

Yu³

et al. 2007

European Respiratory Journal

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Increased oxidative stress has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the risk of COPD and the substitution of alanine 16 with valine (Ala16Val) polymorphism of manganese-superoxide dismutase (Mn-SOD) and the cytosine to thymidine transition of nucleotide -262 (-262C.T) polymorphism of the catalase gene, and the activity of erythrocyte SOD and catalase.The subjects were stable COPD patient ever smokers (n5165) and healthy controls, matched for age and cigarette consumption. Genotyping of Mn-SOD at Ala16Val and the catalase gene at -262C.T was performed, and the functional activity of SOD and catalase in erythrocytes determined.There were no significant differences in the distribution of the different genotypes or allele frequencies between patients and controls for both the Mn-SOD and catalase genes. Among healthy controls or COPD patients, no differences were observed in erythrocyte SOD and catalase activity, irrespective of genotype. Significantly higher erythrocyte catalase activity was found in COPD patients than in healthy controls. The T/T catalase genotype and Ala/Ala Mn-SOD genotype were uncommon in the present Chinese population.The increase in erythrocyte catalase activity in Chinese patients with chronic obstructive pulmonary disease probably indicates dysfunction of the oxidant/antioxidant defence system, but it is unclear whether this increase is compensatory or a pathogenic factor.

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Section: Discussionsupporting

confidence: 92%

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Mak

Ho²,

Yu³

et al. 2007

European Respiratory Journal

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“…23 Lipid peroxidation is the oxidation reaction between ROS and polyunsaturated fatty acids, which eventually causes changes in the structure and permeability of the lung membrane. 24 The second biomarker, 8-oxo-7,8-dihydro-2Ј-deoxyguanosine, is primarily involved in DNA damage. The mechanism for this damage is the guanine:cytosine to adenine:thymine transversion on DNA replication, 25 which induces microsatellite instability and abnormal apoptosis or necrosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome

et al. 2015

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BACKGROUND: Oxidative damage is a major contributing factor to carcinogenesis and obstructive disorders in lungs. Current evidence suggests that the inflammatory processes yield to oxidative mechanisms, which underlie COPD, lung cancer, and obstructive sleep apnea syndrome (OSAS). This study aimed to evaluate the oxidative damage in these diseases by evaluating the oxidative and antioxidant biomarkers. METHODS: Malondialdehyde, 8-oxo-7,8-dihydro-2-deoxyguanosine, and coenzyme Q10 levels were evaluated in the blood samples of subjects with COPD, lung cancer, and OSAS by high-pressure liquid chromatography. RESULTS: A total of 111 participants (35 females, 76 males) with OSAS (n ‫؍‬ 29), COPD (n ‫؍‬ 26), and lung cancer (n ‫؍‬ 28) and healthy controls (n ‫؍‬ 28) were included in the study. The malondialdehyde and coenzyme Q10 levels were significantly higher in all 3 diseases when compared with controls (P < .01), whereas 8-oxo-7,8-dihydro-2-deoxyguanosine levels were only significantly higher than in healthy controls in subjects with lung cancer (P ‫؍‬ .005). The highest levels of malondialdehyde and coenzyme Q10 were determined in subjects with OSAS and lung cancer, respectively. The highest 8-oxo-7,8-dihydro-2-deoxyguanosine levels were also observed in subjects with lung cancer, but the differences of this biomarker with other diagnoses were not statistically significant (P ‫؍‬ .56). CONCLUSION: Oxidative damage was observed in all 3 diagnoses, and, as a response to oxidative stress, antioxidant mechanisms were also active in these diseases. Malondialdehyde and 8-oxo-7,8-dihydro-2-deoxyguanosine were found to be efficiently usable in the evaluation of oxidative damage in chronic respiratory diseases. (ClinicalTrials.gov registration NCT02406053.) Key words: malondialdehyde; 8-oxo-7,8-dihydro-2Ј-deoxyguanosine;coenzyme Q10; COPD; OSAS; lung cancer; oxidative damage; antioxidants. [Respir Care 2016;61(2):205-211.

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“…They claimed that oxidative stress is an important physiopathological change in COPD. Hanta et al measured erythrocyte superoxide dismutase enzyme activity and plasma malonyldialdehyde levels in 162 subjects (30 healthy nonsmokers, 30 healthy smokers, 71 patients with stable COPD, and 31 patients with COPD exacerbation) (36). They found that the healthy smokers and stable and exacerbated patients with COPD had an impairment in the oxidant-antioxidant balance.…”

Section: Total Oxidant Statusmentioning

confidence: 99%

Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

Genç¹,

Üçok²,

Şener³

et al. 2014

Turk J Med Sci

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IntroductionChronic obstructive pulmonary disease (COPD), one of the most common chronic diseases, is a major cause of morbidity. Oxidative stress is a situation of imbalance between free radicals and antioxidants in favor of the oxidants (1). Today, habitual smoking is the most significant threat to the world's population (2). The development of COPD is mainly associated with tobacco or biomass smoke-induced oxidative stress. Smokers are exposed to thousands of reactive chemicals and trillions of radicals and particles with every cigarette; thus, the molecular reactive oxygen, activity of radicals, and nitrogen species can, over time, lead to a number of detrimental changes in the lungs (3). Oxidative stress is thought to play a central role in the pathogenesis of COPD.Maximal aerobic capacity (VO 2 max) is considered the gold standard for evaluating cardiorespiratory fitness (physical functional capacity) (4). Daily physical activity is the actual level of physical performance that one adopts in daily living. It is not synonymous with physical functional capacity, which can be defined as the maximal performance potential of an individual (5). Aerobic exercise limitation is a common and disturbing manifestation of COPD and is often caused by multiple interrelated physiologic and anatomic disturbances (6). Nevertheless, a hypothesis was proposed that individuals with higher current aerobic function will have greater antioxidant and metabolic capacities to deal with the stresses associated with life, including environmental stresses such as chronic cigarette smoke exposure (3).Patients with COPD show high prevalences of cardiovascular diseases and metabolic syndrome (7,8). Obesity and COPD are common and disabling chronic health conditions. A relationship between obesity and COPD is increasingly recognized, although the nature of this association remains unknown (9). Uygur et al. also found that body fat percentage and total body fat were negatively correlated at a strong level with aerobic capacity Background/aim: To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls. Materials and methods:The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured.Results: Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the controls. The total oxidant value, body fat percentage, and waist/hip ratio were higher in patients with COPD than in the healthy controls. There was a moderately negative correlation between the total oxidant value and the maximal aerobic capacity, while there was a moderatel...

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Oxidant–Antioxidant Balance in Patients with COPD

Cited by 46 publications

References 16 publications

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Evaluation of Oxidative Damage and Antioxidant Mechanisms in COPD, Lung Cancer, and Obstructive Sleep Apnea Syndrome

Association analyses of oxidative stress, aerobic capacity, daily physical activity, and body composition parameters in patients with mild to moderate COPD

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