Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus

Ali, Ehab M.M.; Shehata, Hanan H.; Ali-Labib, Randa; Zahra, Lamia M. Esmail

doi:10.1016/j.clinbiochem.2009.06.007

Cited by 39 publications

(23 citation statements)

References 37 publications

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“…MPO levels and the G-463A polymorphism have been involved in the pathogenesis of several diseases and cancers. Authors suggest a possible correlation of excessive production of reactive oxygen species and disease's severity [15,[20][21][22][23][24]. In the present study, we found that patients infected by HCV with HCC had higher MPO plasma levels than patients without HCC.…”

Section: Discussioncontrasting

confidence: 37%

Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C

et al. 2012

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Section: Discussioncontrasting

confidence: 37%

Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C

et al. 2012

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“…Ali et al 33 have shown that serum MDA and NO levels and myeloperoxidase activity were significantly higher, and the activities of paraoxonase and arylesterase were significantly lower in 23 Egyptian patients with chronic HCV hepatitis compared to 21 healthy subjects. Nakhjavani et al 34 have reported that oxidative stress and lipid peroxidation play a major role in liver injury in chronic HCV infection and that viral load correlated with the serum level of oxidized LDL.…”

Section: Discussionmentioning

confidence: 99%

RANTES, TNF-α, Oxidative Stress, and Hematological Abnormalities in Hepatitis C Virus Infection

Tawadrous

Aziz²,

Amin³

et al. 2012

Journal of Investigative Medicine

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“…Several factors like nutritional, pharmacological, genetic and infectious processes have been demonstrated to modulate PON1 levels [9]. Relationship between PON1 activity and infectious pathogens like HCV and HIV have been shown [26,27]. But, association between H. pylori infection and PON1 has been reported in only one study [4].…”

Section: Discussionmentioning

confidence: 99%

The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects

et al. 2010

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BackgroundThe role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori) infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C) has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1) is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects.MethodsThirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries.ResultsWe found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014). We found that PON1 activities were significantly lower in H. pylori positive subjects compared with negative subjects. No significantly correlation was observed between PON1 and CIMT values.ConclusionsThere is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms.

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Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus

Cited by 39 publications

References 37 publications

Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C

Plasma myeloperoxidase levels correlate with hepatocellular carcinoma in chronic hepatitis C

RANTES, TNF-α, Oxidative Stress, and Hematological Abnormalities in Hepatitis C Virus Infection

The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects

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