Oxetane-containing metabolites: origin, structures, and biological activities

Hydrobiological Aspects of Saturated, Methyl-Branched, and Cyclic Fatty Acids Derived from Aquatic Ecosystems: Origin, Distribution, and Biological Activity

“…In several comparative studies, it was shown that PASS outperforms, in predictivity, some other recently developed methods for the estimation of biological activity profiles [124,125]. Freely available via the Internet, the PASS Online web-service [126] is used by more than thirty thousand researchers from almost a hundred countries to determine the most promising biological activities for both natural and synthetic compounds [127,128]. To reveal the hidden pharmacological potential of the natural substances, researchers have successfully used the past fifteen years [129,130].…”

Oxetanes and Oxetenes: Fused-Ring Derivatives

“…Oxetanes are found in more than 600 naturally occurring structures produced by microorganisms or plants. 149…”

An Erratum

“…[7][8][9][10][11][12][13][14][15] The highly oxygenated diterpenoid (HOD) that belong to a small group of diterpenoid peroxides are of great interest to researchers, since representatives of this group demonstrate a wide range of biological activities. [3,8,[16][17][18][19][20][21][22][23][24][25] The chemical structure of the molecule and its biological activity are in a certain relationship which is called SAR (Structure-Activity Relationship). This idea was first proposed by Brown and Fraser in 1868 [26] more than 150 years ago, however, it was widely used and used in the mid-70s, the twentieth century.…”

“…For the last fifteen years, in our scientific studies of the biological activity of both natural and synthetic compounds, we have been using the well-known PASS software. [19][20][21][22][23][24] The PASS program contains information from more than a million chemical compounds, both natural and synthetic, that correlate with more than 9,000 biological activities taken from published information sources. [34,35] In this review, we present the biological activity of the diterpenoid hydro-and endoperoxides isolated from algae, liverworts and plants.…”