Oxandrolone therapy in stunting and in ovarian dysgenesis

Abstract

Therapy of stunted children with oxandrolone has been associated with probable acceleration of vertical growth in 11 out of 20 patients. This was generally not accompanied by acceleration of skeletal maturation. One of three patients with proved gonadal dysgenesis grew faster during treatment. Sexual pseudoprecocity did not develop in the males nor were arrhenomimetic effects observed in the females.

Adult Height in Turner Syndrome: Results of a Multinational Survey 1993

“…It is another unexpected finding of the survey that in general there is neither gain nor loss in adult height when estrogen/oxandrolone treat ment is introduced after the age of 14 years. When applied during childhood years -alone or in combination with growth hormone -oxandrolone is known to increase height velocity [19,20], while its effect on adult height is presently uncertain [21]. Similarly, low doses of estrogen have been found to increase height velocity in children with TS [22,23], However, the advancement of bone age observed in these studies suggests that there will be no ultimate gain in adult height through this therapy.…”

Growth hormone and insulin during oxandrolone therapy of stunting

“…These findings, hepatic function indices, and data bearing on possible arrhenomimesis in girls and virilization in boys have been reported earlier. 3,4 Growth Hormone Responses to Tolbutamide. The mean pretolbutamide levels of serum growth hormone of the growth-retarded group was slightly higher than that of the control group, but still within the fasting range for normal subjects.…”