Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy

Lee, Jee Eun; Abuzar, Sharif Md; Seo, Yeji; Han, Hyeji; Jeon, Youngbae; Park, Eun Jung; Baik, Seung Hyuk; Hwang, Sung Joo

doi:10.1016/j.ijpharm.2019.04.065

Cited by 38 publications

(30 citation statements)

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“…The mean plasma concentration–time profiles of oxaliplatin after a single dose (5 mg/kg rat) of oxaliplatin solution and oxaliplatin-loaded liposomal depot in rats are shown in Figure 6 . The samples were administered by IP injection, with a slight modification to a previous method [ 29 , 47 ]. The IP absorption of the oxaliplatin solution was clearly faster than that of the depot samples ( Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

Preparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment

et al. 2020

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Colorectal cancer with peritoneal metastasis has a poor prognosis because of inadequate responses to systemic chemotherapy. Cytoreductive surgery followed by intraperitoneal (IP) chemotherapy using oxaliplatin has attracted attention; however, the short half-life of oxaliplatin and its rapid clearance from the peritoneal cavity limit its clinical application. Here, a multivesicular liposomal (MVL) depot of oxaliplatin was prepared for IP administration, with an expected prolonged effect. After optimization, a combination of phospholipids, cholesterol, and triolein was used based on its ability to produce MVL depots of monomodal size distribution (1–20 µm; span 1.99) with high entrapment efficiency (EE) (92.16% ± 2.17%). An initial burst release followed by a long lag phase of drug release was observed for the MVL depots system in vitro. An in vivo pharmacokinetic study mimicking the early postoperative IP chemotherapy regimen in rats showed significantly improved bioavailability, and the mean residence time of oxaliplatin after IP administration revealed that slow and continuous erosion of the MVL particles yielded a sustained drug release. Thus, oxaliplatin-loaded MVL depots presented in this study have potential for use in the treatment of colorectal cancer.

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Section: Resultsmentioning

confidence: 99%

Preparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment

et al. 2020

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“…Cross-linked HC hydrogels were prepared using variable weight ratios of HA and CMCNa. HC hydrogel synthesis was carried out based on our previous description [18]. In the presence of ADH (as a nucleophile), EDC (a water-soluble carbodiimide) linked both HA and CMCNa molecules with its amine group.…”

Section: Resultsmentioning

confidence: 99%

“…An extensive investigation of the intraperitoneal anti-adhesion efficacy of HC hydrogels was conducted in our previous study, after introducing peritoneal injury to generate peritoneal adhesion [18]. HC hydrogel groups (treated) showed the highest anti-adhesion barrier compared to the control group (non-treated).…”

Section: Resultsmentioning

confidence: 99%

“…Hydrogels were synthesized using variable ratios of HA and CMCNa (Figure 1) by chemical cross-linking, as described by our previous study [18]. Briefly, HA and CMCNa at ratios of 1:2 and 2:1 ( w / w ) were dissolved in deionized water with continuous stirring.…”

Section: Methodsmentioning

confidence: 99%

“…Recently we succeeded in synthesizing novel hyaluronic acid (HA) and carboxymethyl cellulose sodium (CMCNa)-based cross-linked (HC) hydrogels loaded with oxaliplatin [18]. These novel HC hydrogels significantly prevented intraperitoneal adhesion and offered the highest anti-adhesion barrier in an in vivo rat model.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic Profile and Anti-Adhesive Effect of Oxaliplatin-PLGA Microparticle-Loaded Hydrogels in Rats for Colorectal Cancer Treatment

et al. 2019

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Colorectal cancer (CRC) is one of the most malignant and fatal cancers worldwide. Although cytoreductive surgery combined with chemotherapy is considered a promising therapy, peritoneal adhesion causes further complications after surgery. In this study, oxaliplatin-loaded Poly-(d,l-lactide-co-glycolide) (PLGA) microparticles were prepared using a double emulsion method and loaded into hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based cross-linked (HC) hydrogels. From characterization and evaluation study PLGA microparticles showed smaller particle size with higher entrapment efficiency, approximately 1100.4 ± 257.7 nm and 77.9 ± 2.8%, respectively. In addition, microparticle-loaded hydrogels showed more sustained drug release compared to the unloaded microparticles. Moreover, in an in vivo pharmacokinetic study after intraperitoneal administration in rats, a significant improvement in the bioavailability and the mean residence time of the microparticle-loaded hydrogels was observed. In HC21 hydrogels, AUC0–48h, Cmax, and Tmax were 16012.12 ± 188.75 ng·h/mL, 528.75 ± 144.50 ng/mL, and 1.5 h, respectively. Furthermore, experimental observation revealed that the hydrogel samples effectively protected injured tissues from peritoneal adhesion. Therefore, the results of the current pharmacokinetic study together with our previous report of the in vivo anti-adhesion efficacy of HC hydrogels demonstrated that the PLGA microparticle-loaded hydrogels offer novel therapeutic strategy for CRC treatment.

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Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

Sala

Fabozzi

Gennaro

et al. 2021

Macromolecular Bioscience

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Cancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)‐based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic‐ and inorganic‐based NPs, is highlighted. Subsequently, HA‐based nanostructures and their applications in cancer therapy are presented.

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Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy

Cited by 38 publications

References 38 publications

Preparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment

Preparation and Evaluation of Intraperitoneal Long-Acting Oxaliplatin-Loaded Multi-Vesicular Liposomal Depot for Colorectal Cancer Treatment

Pharmacokinetic Profile and Anti-Adhesive Effect of Oxaliplatin-PLGA Microparticle-Loaded Hydrogels in Rats for Colorectal Cancer Treatment

Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

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