Advances in Hyaluronic‐Acid‐Based (Nano)Devices for Cancer Therapy

Abstract

Cancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)‐based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic‐ and inorganic‐based NPs, is highlighted. Subsequently, HA‐based nanostructures and their applications in cancer therapy are presented.

Synthesis of hyaluronic acid core–shell nanoparticles via simple microfluidic-assisted nanoprecipitation method for active tumor targeting

“…More specifically, it is possible to note that the IRI-NPs formulated by MM showed higher cytotoxicity effect compared to BM, probably due to the better stability of the NPs; the endocytosis mediated by the HA receptor was found to be more effective, thus allowing a better cellular absorption of NP in CD44+ cells. 19 Fig. 6 shows the representative morphology of the tumor (HS578T) and healthy (L929) cell lines after exposure to different types of NPs fabricated by MM.…”

“…16,17 This naturally anionic polysaccharide is composed of repeating disaccharide units of β- d -glucuronic acid and N -acetyl- d -glucosamine that specifically binds the CD44 receptor, which is overexpressed in many cancer cells. 18 In the literature, a wide set of HA-based drug carriers, obtained by chemical conjugation, have been investigated for tumor targeting; 17,19,20 however, chemical modifications on the HA backbone can modify its biological properties. 21 Recently, core–shell HA/poly(lactic- co -glycolic acid) (PLGA) NPs composed of a hydrophobic PLGA core sealed by amphiphilic poloxamers (PF68 and PF127, even named PP) and HA shell have been developed by means of nanoprecipitation with subsequent solvent evaporation BM.…”

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma

“…NIR dyes and porphyrin analogs afford both multimodal imaging and PTT effects. For example, hyaluronic acid-anthocyanine-like dye-iron composite NPs are available for fluorescence imaging, magnetic resonance multimodality imaging and PTT ( Della Sala et al, 2022 ; Wang et al, 2020 ; Hu et al, 2015 ). It is rapidly elevated to 28°C with approximately 5 min of irradiation at 1 W/cm2 under a 785 nm laser to facilitate tumor elimination in MCF-7 xenograft mice ( Tian et al, 2016 ).…”

A Hyaluronic Acid-Based Formulation with Simultaneous Local Drug Delivery and Antioxidant Ability for Active Viscosupplementation

“…HA, indeed, controls viscoelastic properties of soft tissues, cell growth, proliferation, and tissue remodeling. 1 In the articular joints, HA confers to the synovial fluid (SF) highly viscoelastic properties because of its capability to retain water and to act as an expanded random coil, occupying a large hydrodynamic volume. This causes neighboring molecules to overlap to form a transient network structure with marked viscoelasticity.…”

“…Hyaluronic acid (HA) is a naturally occurring polysaccharide, which is the major component of the extracellular matrix (ECM) in mammalian connective tissues, where it fulfills important physicochemical and biological functions. HA, indeed, controls viscoelastic properties of soft tissues, cell growth, proliferation, and tissue remodeling . In the articular joints, HA confers to the synovial fluid (SF) highly viscoelastic properties because of its capability to retain water and to act as an expanded random coil, occupying a large hydrodynamic volume.…”