Synthesis of hyaluronic acid core–shell nanoparticles <i>via</i> simple microfluidic-assisted nanoprecipitation method for active tumor targeting

Borzacchiello, Assunta; Fabozzi, Antonio; Sala, Francesca Della; Gennaro, Mario di

doi:10.1039/d2nj03279a

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…Moreover, a microfluidic method for both small and large-scale NP production is the use of a NanoAssemblr™. The microfluidic NanoAssemblr™ platform is employed for the rapid and controlled synthesis of a variety of NPs such as polymer-based 75 NPs and polymer-lipid-based NPs in the nanomedicine field. 76 In particular, the microfluidic mixer is designed to achieve optimization for precise control of the physicochemical properties requiring nanoparticle self-assembly in the nanomedicine field.…”

Section: Microfluidic Systems Based On Multiphase Flowmentioning

confidence: 99%

Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

et al. 2023

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Section: Microfluidic Systems Based On Multiphase Flowmentioning

confidence: 99%

Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

et al. 2023

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“…For the preparation of the HyA-based carrier system (as hydrogels [6,7], microparticlegel systems [8], cell microcarriers [9], nanohydrogels [10], nanoemulsions [11], core-shell carriers [12], nanoconjugates [13], etc. ), the hydrophilic character of the polysaccharide needs to be modified, which can be achieved through cross-linking [14], chemical structural modifications [15], or electrostatic interactions [16].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Concentration, Temperature, and pH on the Formation of Hyaluronic Acid–Surfactant Nanohydrogels

Serés

Csapó

Varga

et al. 2023

Gels

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The assembly of colloidal hyaluronic acid (HyA, as a polysaccharide) based hydrogel particles in an aqueous medium is characterized in the present paper, with an emphasis on the particular case of nanohydrogels formed by surfactant-neutralized polysaccharide networks. The structural changes and particle formation process of polysaccharide- and cationic-surfactant-containing systems were induced by the charge neutralization ability and the hydrophobic interactions of cetyltrimethylammonium bromide (CTAB) under different conditions. Based on the rheological, light scattering, ζ-potential, turbidity, and charge titration measurements, it can be concluded that the preparation of the HyA-CTAB particles can be greatly controlled. The results indicate that more available negative charges can be detected on the polymer chain at smaller initial amounts of HyA (cHyA < 0.10 mg/mL), where a molecular solution can be formed. The change in the pH has a negligible effect on the formation process (particle aggregation appears at nCTAB/nHyA,monomer~1.0 in every case), while the temperature dependence of the critical micelle concentration (c.m.c.) of CTAB determines the complete neutralization of the forming nanohydrogels. The results of our measurements confirm that after the appearance of stable colloidal particles, a structural change and aggregation of the polymer particles take place, and finally the complete charge neutralization of the system occurs.

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Advances in Microfluidic‐Based Core@Shell Nanoparticles Fabrication for Cancer Applications

Almeida,

Gil,

Guillot

et al. 2024

Adv Healthcare Materials

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Current research in cancer therapy focuses on personalized therapies, through nanotechnology‐based targeted drug delivery systems. Particularly, controlled drug release with core‐shell nanoparticles can be designed to safely transport various active agents, optimizing delivery to specific organs and tumors, minimizing side effects. The use of microfluidics in this field has stood out against conventional methods by allowing precise control over parameters like size, structure, composition, and mechanical/biological properties of nanoscale carriers. This review compiles applications of microfluidics in the production of core‐shell nanoparticles for cancer therapy, discussing the versatility inherent in various microchannel and/or micromixer setups and showcasing how these setups can be utilized individually or in combination, as well as how this technology allowed the development of new advances in more efficient and controlled fabrication of core‐shell nanoformulations. Recent biological studies have achieved an effective, safe and controlled delivery of otherwise unreliable encapsulants such as siRNA, pDNA, and cisplatin as a result of precisely tuned fabrication of nanocarriers, showing that this technology is paving the way for innovative strategies in cancer therapy nanofabrication, characterized by continuous production and high reproducibility. Finally, this review analyses the technical, biological, and technological limitations that currently prevent this technology from becoming the standard.This article is protected by copyright. All rights reserved

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Synthesis of hyaluronic acid core–shell nanoparticles via simple microfluidic-assisted nanoprecipitation method for active tumor targeting

Abstract: The physicochemical properties control of hyaluronic acid core-shell nanoparticles (HA-based NPs) is a suitable strategy to achieve the high reproducibility of biological assays. In particular, the active targeting efficiency of...

Cited by 8 publications

References 42 publications

Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

The Effect of Concentration, Temperature, and pH on the Formation of Hyaluronic Acid–Surfactant Nanohydrogels

Advances in Microfluidic‐Based Core@Shell Nanoparticles Fabrication for Cancer Applications

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