2014
DOI: 10.1016/j.neures.2014.02.004
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Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve

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Cited by 25 publications
(18 citation statements)
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“…It is conceivable that neurodegeneration, such as axonopathy, neuronopathy, or myelinopathy, are responsible for oxaliplatin-dependent chronic neuropathy [7][8][9] . In the present study, we examined the protective property of alogliptin on oxaliplatin-induced peripheral neuropathy focused on axonopathy.…”
Section: Discussionmentioning
confidence: 99%
“…It is conceivable that neurodegeneration, such as axonopathy, neuronopathy, or myelinopathy, are responsible for oxaliplatin-dependent chronic neuropathy [7][8][9] . In the present study, we examined the protective property of alogliptin on oxaliplatin-induced peripheral neuropathy focused on axonopathy.…”
Section: Discussionmentioning
confidence: 99%
“…Although a detailed mechanism of neuropathy development due to chemotherapy has not been identified, it is reported that oxaliplatin causes morphological degeneration, including axonal disorder, neuronal cell damage and myelin alternation. [9][10][11][12][13] It has recently reported that the knockout of nuclear factor-erythroid-2-related factor 2 (Nrf2) aggravates oxaliplatin-induced mechanical allodynia and that the activation of the Nrf2 signaling pathway ameliorates oxaliplatin-induced neuropathy in mice. 14) Dimethyl fumarate (DMF) is a drug for treating multiple sclerosis.…”
Section: Introductionmentioning
confidence: 99%
“…BACE1‐mediated processing of NRG1 leads to its interaction with neighbouring ErbB family receptors, which are expressed in Schwann cells. Interestingly, oxaliplatin was reported to reduce NRG1 expression in the sciatic nerve (Tsutsumi et al, ). Reduced axonal NRG1 causes a decrease in the nerve conduction velocity that is associated with hypomyelination in sciatic nerves (Michailov et al, ).…”
Section: Discussionmentioning
confidence: 99%