Ovulatory Failure in Rats After Treatment with Brain Norepinephrine Depletors

Coppola, J. A.; Leonardi, R; Lippmann, W.

doi:10.1210/endo-78-1-225

Cited by 46 publications

(15 citation statements)

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“…It also provides an explanation for the in vitro effect of 5-HT reported by M oszkowska, who has shown that the amine antagonizes the gonadotropic releasing activity of hypothalamic fragments incubated with adenohypophyscal tissue [25]; in this particular instance, 5-HT is more likely to affect the release of LRF present in the hypotha lamic tissue, rather than the physiological activity in the incubated brain fragments. Surprisingly, decreased brain catecholamine levels following a-MT treatment did not affect ovulation under our experimental conditions, in contrast to the findings reported by other authors [4,5,18]. This divergence of opinion could be due to differences in the route of administration; in the experiments cited, the results were obtained after intraperitoneal a-MT, whereas we gave it per os, since the ingested drug is less toxic [24] and seems equally potent in blocking NA synthesis [15,24].…”

Section: Discussioncontrasting

confidence: 80%

“…Since neither increased nor decreased local catecholamine levels interfered with ovulation under our experimental conditions, we cannot add any further evidence as to the role of catecholaminergic systems in LH control, which has been postulated by various authors [4,5,12,18,29]; cholinergic mechanisms have, equally, been reported to affect LH release [2,29,31], at still undetermined levels of the complex structures controlling gonadotropic regulation [14].…”

Section: Discussionmentioning

confidence: 89%

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Effects of Selective Experimental Changes in Regional Hypothalamic Monoamine Levels on Superovulation in the Immature Rat

Kordon¹

1969

Neuroendocrinology

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 89%

Effects of Selective Experimental Changes in Regional Hypothalamic Monoamine Levels on Superovulation in the Immature Rat

Kordon¹

1969

Neuroendocrinology

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“…However, Coppola et al(1966) and Lippmann et al(1967) stated that when hypothalamic catecholamines were reduced by systemic injection of some pharmacological drugs, ovulation was suppressed. Kordon and Glowinski (1969) have also shown using cxmethyl-p-tyrosine, an inhibitor of catecholamine synthesis, that DA is necessary for ovulation of the rat at a critical time of the day of proestrus.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dopamine Implanted in the Median Eminence on the Estrous Cycle of the Rat

Uemura¹,

Kobayashi²

1971

Endocrinol Japon

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SynopsisA mixture (DA-C) of dopamine hydrochloride and cholesterol in a ratio of 2 to 1 or 5 to 1 by weight was implanted into different hypothalamic regions of the rat and allowed to persist for more than two weeks. The estrous cycles and ovarian histology were examined to determine effects of the treatment. When the tip of the cannula containing DA-C (2 to 1) hit the posterior median eminence (ME) and a small part of the arcuate nucleus (AN), the rats showed prolonged estrus. The ovaries of these rats showed big follicles and no corpora lutea. When the tip of the cannula of DA-C (5 to 1) hit the posterior ME and a small part of the AN, the rats showed prolonged diestrus. The follicles and corpora lutea were small in the ovaries of these rats. Under our experimental conditions, DA seems to inhibit LH and FSH release at the level of the ME. When the tips of the cannulae containing DA-C were placed in AN, n. ventromedialis, n. premamillaris ventralis, n. premamillaris dorsalis, n. dorsomedialis pars ventralis or adenohypophysis, the rats showed cycles with or without minor irregularities.

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“…Reserpine also inhibits ovulation induced by pregnant mare's serum (PMS) in immature mice [B row n, 1966] and in immature rats [Coppola et at., 1966]. In the latter case, the inhibition is partiallyreversed by prior administration of the MAOI, iproniazid, or by subsequent treatment with human chorionic gonadotrophin (HCG).…”

Section: Pargyline Reserpine Human Chorionic Gonadotrophin Pregnant Mmentioning

confidence: 99%

Reversal by Pargyline of Reserpine Block of Induced Ovulation – Direct Ovarian Effects

France¹

1970

Neuroendocrinology

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A single injection of 62.5 µg reserpine inhibits ovulation induced in intact immature rats by administration of pregnant mare’s serum (PMS) and human chorionic gonadotrophin (HCG) when reserpine is given ½ to 6½ h before HCG. Increases or decreases in the amount of HCG are not reflected by similar changes in the ovulatory response of reserpinized rats, indicating that reserpine’s action is not due to an antagonism of HCG. The monoamine oxidase inhibitor (MAOI), pargyline, partially reverses the inhibitory effect of reserpine, although it has no effect on ovulation per se. Previous experiments with reserpine suggested that its inhibitory effect on ovulation was due to its ability to block luteinizing hormone (LH) release. The present experiments circumvent the necessity for consideration of LH release, since HCG is given exogenously in amounts adequate to induce ovulation. It is clearly evident from our results that reserpine exerts a direct effect on the ovary in addition to its effect at the hypothalamo-hypophyseal level.

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Ovulatory Failure in Rats After Treatment with Brain Norepinephrine Depletors

Cited by 46 publications

References 0 publications

Effects of Selective Experimental Changes in Regional Hypothalamic Monoamine Levels on Superovulation in the Immature Rat

Effects of Selective Experimental Changes in Regional Hypothalamic Monoamine Levels on Superovulation in the Immature Rat

Effects of Dopamine Implanted in the Median Eminence on the Estrous Cycle of the Rat

Reversal by Pargyline of Reserpine Block of Induced Ovulation – Direct Ovarian Effects

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