Reversal by Pargyline of Reserpine Block of Induced Ovulation – Direct Ovarian Effects

France, E.S.

doi:10.1159/000121910

Cited by 9 publications

(5 citation statements)

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“…In a number of species, drugs which modify adrenergic mechanisms can affect fertility. Drugs with such actions include reserpine (Coppola, Leonardi & Lippmann, 1966;Deanesley, 1966;Hopkins & Pincus, 1963;Khazan, Sulman & Winnik, 1960); pargyline (France, 1970); chlorpromazine, a-methyldopa and tetrabenazine (Coppola et al, 1966); phenoxybenzamine (Ferrando & Nalbandov, 1969;Virutamasen et al, 1971); a-methyltyrosine (Kamberi, 1973) and a number of agents interacting with dopaminergic mechanisms (Fuxe e t al., 1973), e.g., haloperidol (Chand et al, 1973). The majority of the evidence indicates that, subject to certain species variations, the important site of action for these drugs is the hypothalamico-hypophysial axis.…”

Section: Effects Of Ovarian Denervation Transplan Ration and Drugs Mmentioning

confidence: 99%

The Sympathetic Innervation of the Mammalian Ovary. A Review of Pharmacological and Histological Studies

Mohsin

Pennefather

1979

Clin Exp Pharmacol Physiol

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The a i m of this article is to review the literature concerning the nature and function of the sympathetic innervation of the mammalian ovary. We focus our attention upon evidence relating to suggestions that ovarian smooth muscle participates in ovulatory events, and that such participation may be modulated by the local neural supply. Guttmacher & Guttmacher (1921) mentioned that this possibility was first suggested nearly 70 years before they observed smooth muscle-like cells in the follicular walls of sow ovaries and found that isolated follicular walls were contracted by physostigmine and relaxed by adrenaline. However, Claessen (1 947), using polarisation microscopy, was unable to confirm the presence of smooth muscle in the apices of follicles from a number of species, and interest in the Guttmachers' findings temporarily lapsed.In 1967, Jacobowitz & Wallach reported the findings of a histological study of ovaries from cats, monkeys and humans in which they observed catecholamine fluorescence associated with smooth muscle-like cells in the stroma. In 1969, Rocereto, Jacobowitz & Wallach demonstrated that the cat isolated ovary exhibited spontaneous mechanical activity and was reactive to catecholamines. These investigations together with those of Owman & Sjoberg (1966) and Sjoberg (1967) initiated a resurgence of interest in the possibility that the adrenergic innervation of the ovary may play a functional role in ovarian processes; in particular that it might affect the contractility of smooth muscle and so participate in ovulation.With the development of techniques such as electron microscopy and fluorescence histochemistry, together with greater sophistication of pharmacodynamic analysis, an increasing number of publications concerned with the role of smooth muscle and adrenergic innervation in the ovary has appeared in the recent literature.Reference to some of this work is found in the reviews of Marshall (1972, 1973) t and Bell (1972). A comprehensive review devoted specifically to the roles of catecholamines and nerves in ovulation was published by Bahr, Kao & Nalbandov in 1974. Their review described the sympathetic innervation of avian as well as of mammalian ovaries and the possible function of such innervation. They considered evidence relating to several possible roles, including modification of contraction of ovarian smooth muscle, participation in ovulation, and/or control of the ovarian vasculature, and concluded that nerves play some role in ovulation, but that it is not clear how this effect is mediated.

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Section: Effects Of Ovarian Denervation Transplan Ration and Drugs Mmentioning

confidence: 99%

The Sympathetic Innervation of the Mammalian Ovary. A Review of Pharmacological and Histological Studies

Mohsin

Pennefather

1979

Clin Exp Pharmacol Physiol

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“…However, evidence has also accumulated to suggest that this might not be the sole mechanism of reserpine action in inhibiting ovulation. A direct effect on the ovary was suggested by experiments on immature mice by Purshottam (9), and on immature rats by Hopkins and Pincus ( l o ) and France ( 11) since the compound inhibited ovulation induced by a combination of PMS and HCG.…”

Section: Ejtecd Of Reserpine Alone and In Combination With Pargyline mentioning

confidence: 99%

Effect of Reserpine on Plasma LH Levels in Ovariectomized and Cycling Proestrus Rats

Ratner

McCann

1971

Experimental Biology and Medicine

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In recent years, increasing attention has been paid to the influence of drugs acbing on the central nervous system upon the function of the anterior pituitary (1). Special interest has been attached to the effects of reserpine upon the release of ovulating hormone. Reserpine, when injected into a proestrus female rat a few hours in advance of the "critical" period for lu teinizing hormone (LH) release will prevent the ovulation that would otherwise follow (2). The drug is ineffective if injected immediately after the critical period. Meyerson and Sawyer ( 3 ) showed that the ovulatory blockade produced by reserpine could be prevented by prior treatment with either of the monoamine oxidase (MAO) inhibitors, pargyline or nialamide. Similar results have been obtained in the gonadotropinprimed immature rats (4).The effect of reserpine upon ovulation and the ability of pretreatment with M A 0 inhibitors to counteract the blockade suggest that monoaminergic pathways in the hypothalamus play a significant role in controlling the secretion of LH. However, experiments attempting to correlate changes in functional levels of monoamines, such as occur after reserpine treatment, with actual levels of LH in the b l d are lacking. I t was the purpose of the present experiments to investigate: (a) the effects of reserpine upon blood LH levels in the ovariectomized and prwstrous rat; and (b) the effect of pretreatment with pargyline on blood LH levels in the reserpinetreated proestrous rat.Materials and Methods. Experimental animals. Female Sprague-Dawley rats (body wt, 200-250 g) were used in these studies. Unless otherwise stated, all rats were caged in 1 Supported by Grant #AM 10073 from the Public Health Service and a Ford Foundation Grant.an air-conditioned, temperature-controlled room with a lighting schedule of 14 hr of light and 10 hr of darkness, and supplied with Purina laboratory chow and water ad libitum. Under these conditions, the ovulatory surge of LH is expected to occur on the day of proestrus between 1400 and 1600 ( S ) , the "critical" period.Ovariectomized rats. The rats were used 3-6 weeks postovariectomy. Reserpine was administered for 3 days. On the day 4, the rats were bled; and plasma LH was measured. In order to control the effect of weight loss in the reserpine-treated animals, the saline-treated control animals were starved for 3 days prior to bleeding.Normal rats. Vaginal smear records were taken each day and animals were used in the experiment on the day of proestrus, provided they displayed: (a) a clear +day cyclicity in 3 consecutive cycles; (b) a typical proestrus smear; and ( c ) a clearly distended uterus. The uterus was inspected on the morning of proestrus by laparotomy approached by a single lateral incision while the rat was under light ether anesthesia. Blood was collected between 1500 and 1600; and plasma LH was measured. Effects upon ovulation were determined by removing the oviducts on the following day ("estrus") and counting the ova under a microscope. Ovulation was considered complete...

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“…Using reserpine as a blocking agent, Hopkins & Pincus, (1963), Meyerson & Sawyer (1968) and France (1970) postulate that reserpine blocks both central adrenergic mechanisms and also the adrenergic innervation of the ovary, modifying ovarian response to gonadotrophins. Sawyer & Clifton (1980) conclude that "the aminergic innervation of the hypothalamus may influence pituitary secretion in a modulatory manner, without being absolutely mandatory to the process.…”

Section: Please Scroll Down For Articlementioning

confidence: 99%

Differences in the ability of reserpine and chlorpromazine to block ovulation throughout the estrous cycle of the rat

Domı́nguez¹,

Zipitría²,

Riboni³

et al. 1985

Journal of Interdisciplinary Cycle Research

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Reversal by Pargyline of Reserpine Block of Induced Ovulation – Direct Ovarian Effects

Cited by 9 publications

References 1 publication

The Sympathetic Innervation of the Mammalian Ovary. A Review of Pharmacological and Histological Studies

The Sympathetic Innervation of the Mammalian Ovary. A Review of Pharmacological and Histological Studies

Effect of Reserpine on Plasma LH Levels in Ovariectomized and Cycling Proestrus Rats

Differences in the ability of reserpine and chlorpromazine to block ovulation throughout the estrous cycle of the rat

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