Ovine placental perfusion balance: Effect of marijuana smoke

Clapp, James F.; Keve, Tara M.; Vial, C; McLaughlin, Margaret K.

doi:10.1016/0002-9378(88)90569-8

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…Cannabis is lipophilic; it readily crosses the placental barrier 109 and impacts on fetal brain development. 110 Many women perceive cannabis to be safe in pregnancy.…”

Section: The Impact Of Substances On Pregnancy and Child Outcomesmentioning

confidence: 99%

Substance use in pregnancy: The medical challenge

Louw

2018

Obstet Med

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Substance use contributes significantly to the global burden of disease. Growing numbers of women use nicotine, alcohol, and illicit substances. Women are the most vulnerable to problematic substance use in their reproductive years. The first 1000 days of life, starting at conception, have been established as a critical window of time for long-term health and development. Substance use in pregnancy is associated with negative pregnancy and child health outcomes. The impact of antenatal substance use on these outcomes needs to be considered within a challenging and complex context. This review provides an overview of the current literature on the impact of substances on pregnancy and child outcomes as well as the evidence and guidelines on screening and interventions for women using substances during pregnancy.

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“…Cannabis is lipophilic; it readily crosses the placental barrier 109 and impacts on fetal brain development. 110 Many women perceive cannabis to be safe in pregnancy.…”

Section: The Impact Of Substances On Pregnancy and Child Outcomesmentioning

confidence: 99%

Substance use in pregnancy: The medical challenge

Louw

2018

Obstet Med

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“…Cannabinoids freely cross the placental barrier and have been shown to increase blood flow in the bovine placenta, although fetal oxygenation is decreased, suggesting vasoconstrictive effects on the placental microcirculation. 20 Cannabinoids also reach the fetal brain in significant amounts due to their lipophilic nature and the immaturity of the blood -brain barrier. At a cellular level, THC has been shown to be toxic to neonatal cortical cells and in rodent studies prenatal exposure to cannabinoids has been associated with significant congenital malformations including spina bifida and exencephaly, 18,19 as well as alterations in CNS development and long-term effects on behaviour.…”

Section: Marijuana/cannabinoidsmentioning

confidence: 99%

Illicit substance use in pregnancy – a review

Scott

Lust

2010

Obstet Med

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Summary: Illicit substance use is not uncommon in women of childbearing age. The direct effects of illicit substance use on the mother, pregnancy and the fetus are not well understood, in contrast to the indirect effects of social disadvantage and intercurrent medical and psychiatric illness, which are well documented. We have undertaken a review of the current literature regarding the effects of illicit substance use in pregnancy and include a suggested approach to identification and management of at-risk women.

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Current Concepts in Substance Abuse During Pregnancy

Szeto¹

1990

Current Perinatology

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Ovine placental perfusion balance: Effect of marijuana smoke

Cited by 8 publications

References 10 publications

Substance use in pregnancy: The medical challenge

Substance use in pregnancy: The medical challenge

Illicit substance use in pregnancy – a review

Current Concepts in Substance Abuse During Pregnancy

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