Ovine gammaherpesvirus-2 infection associated with chronic interstitial pneumonia in a sheep

Headley, Selwyn Arlington; Agnol, Alais Maria Dall; Navolar, Felipe Martins Negreiros; Frucchi, Ana Paula Souza; Matos, Andressa Maria Rorato Nascimento de; Pereira, Priscilla Fajardo Valente; Xavier, Ana Aparecida Correa; Santos, Vítor Hugo dos; Silva, Luara Evangelista; Depes, Victoria Coronado Antunes; Alfieri, Alice Fernandes; Cunha, Cristina W.

doi:10.1016/j.micpath.2021.105220

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…Therefore, these infectious studies have confirmed that initial replication of OvGHV2 can occur within the lungs 42,45,46 , and provide a plausible explanation for the severe pneumonia identified in the 2-day-old calf during this study. Consequently, the documented experimental [41][42][43][44][45][46] , and natural 32,34,35,37 infectious of OvGHV2 associated pulmonary diseases, as well as the results herein described, corroborate with the hypothesis that OvGHV2 should be considered as a potential pathogenic agent of BRD 2 .…”

Section: Discussionsupporting

confidence: 86%

“…Although the infection was acute in the calf that died with histological evidence of pulmonary lesions, the cow demonstrated the classical manifestations of chronic OvGHV2-related infection due to the PVL identified. Similar arterial lesions were identified in cattle 7,32,49,50 , sheep 37 , and bison 40,51 infected with OvGHV2. The PVLs identified in this cow can be classified as Grade 3 arterial lesions associated with infection by OvGHV2, being part of the spectrum of arterial disruptions identified in affected animals 40 .…”

Section: Discussionsupporting

confidence: 63%

“…Vol:. ( 1234567890 We had previously identified OvGHV2 in association with BRD 34 and pulmonary disease in cattle 32,33,35 , and in one sheep 37 with histopathologic evidence of infection but without clinical manifestations of pulmonary disease. Furthermore, in a previous retrospective study of BRD done in Brazil, a MCFV, more likely OvGHV2, was the only pathogen detected in 6.7% (8/120) of cattle with a histological diagnosis of BRD and was the most frequently identified pathogen (53.3%; 64/120) that occurred concomitantly with other common disease agents of pulmonary diseases of cattle, which prompted the theory that this virus may be an adventitious bystander of BRD 2,34 .…”

Section: Discussionmentioning

confidence: 99%

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Association of ovine gammaherpesvirus 2 with an outbreak of acute respiratory disease in dairy cattle

Headley

Agnol

Bessegato³

et al. 2023

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This study investigated the cause of an outbreak of an acute respiratory disease syndrome followed by episodes of diarrhea in a dairy cattle herd from Southern Brazil. Deep nasal swabs (DNS) from asymptomatic calves, calves with pulmonary discomfort, and diarrheic calves after episodes of respiratory distress were used in molecular assays designed to detect the principal pathogens associated with bovine respiratory disease (BRD). Fecal samples were used for the molecular detection of bovine enteric disease agents. Pulmonary tissues from three calves and a cow that died were evaluated by molecular assays to identify 11 agents associated with the development of BRD. The intestinal and pulmonary fragments of one calf and the cow revealed atrophic enteritis and interstitial pneumonia by histopathology, respectively. Immunohistochemistry (IHC) identified intralesional antigens of a malignant catarrhal fever virus, genus Macavirus, within epithelial cells of the lungs and intestines. Molecular assays amplified ovine gammaherpesvirus 2 (OvGHV2) from most of the DNS, and the pulmonary and intestinal fragments from the animals that died, confirming that the Macavirus identified by IHC was OvGHV2. Concomitant pulmonary infections of OvGHV2 with bovine gammaherpesvirus 6 and bovine coronavirus were identified. Additionally, bovine viral diarrhea virus 1b and Aichivirus B were detected in the fecal samples. These findings demonstrated that OvGHV2, a Macavirus, was the disease agent most frequently (81.2%; 13/16) associated with singular pulmonary infections during this outbreak of BRD, suggesting that this virus may be another potential agent of respiratory disease of cattle.

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