Overweight postmenopausal women with different plasma estradiol concentrations present with a similar pattern of energy expenditure and substrate oxidation rate before and after a fatty meal challenge

Santos, Roberta de Souza; Santos, Ancély Ferreira dos; Clegg, Deborah J.; Iannetta, Odilon; Marchini, Júlio Sérgio; Suen, Vívian Marques Miguel

doi:10.1016/j.clnesp.2016.05.003

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…In general, these studies support the idea that menopause per se is associated with increasing abdominal obesity and that visceral fat accumulation may, in part, be secondary to an acceleration of aging-related decline in fat oxidation and metabolic energy expenditure [ 81 ]. While these changes parallel those observed in OVX rodents [ 168 ], a causal relationship between declining ovarian estradiol in menopause and altered body composition and energy balance has been difficult to confirm [ 169 , 170 ]. Some randomized controlled studies have demonstrated that both oral and transdermal estradiol therapy in postmenopausal women are associated with a reduction in central adiposity and an increase in lean body mass [ 171 , 172 ], as well as reductions in insulin resistance and fasting glucose, new-onset type 2 diabetes, blood lipids, blood pressure, adhesion molecules, and procoagulant factors [ 173 ].…”

Section: Discussionmentioning

confidence: 99%

Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys

Kraynak

Willging

Kuehlmann

et al. 2022

Journal of the Endocrine Society

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Ovarian estradiol supports female sexual behavior and metabolic function. While ovariectomy (OVX) in rodents abolishes sexual behavior and enables obesity, OVX in nonhuman primates decreases, but does not abolish, sexual behavior, and inconsistently alters weight gain. We hypothesize that extra-ovarian estradiol provides key support for both functions, and to test this idea, we employed aromatase inhibition to eliminate extra-ovarian estradiol biosynthesis and diet-induced obesity to enhance weight gain. Thirteen adult female marmosets were OVX and received: (1) estradiol-containing capsules and daily oral treatments of vehicle (E2; n=5); empty capsules and daily oral treatments of either (2) vehicle (VEH, 1ml/kg, n=4), or (3) letrozole (LET, 1 mg/kg, n=4). After 7 months, we observed robust sexual receptivity in estradiol, intermediate frequencies in VEH, and virtually none in LET females (p=0.04). By contrast, few rejections of male mounts were observed in estradiol, intermediate frequencies in VEH, and high frequencies in LET females (p=0.04). Receptive head turns were consistently observed in estradiol, but not in VEH and LET females. LET females, alone, exhibited robust aggressive rejection of males. VEH and LET females demonstrated increased % body weight gain (p=0.01). Relative estradiol levels in peripheral serum were E2>>>VEH>LET, while those in hypothalamus ranked E2=VEH>LET, confirming inhibition of local hypothalamic estradiol synthesis by letrozole. Our findings provide the first evidence for extra-ovarian estradiol contributing to female sexual behavior in a nonhuman primate, and prompt speculation that extra-ovarian estradiol, and in particular neuroestrogens, may similarly regulate sexual motivation in other primates, including humans.

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Section: Discussionmentioning

confidence: 99%

Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys

Kraynak

Willging

Kuehlmann

et al. 2022

Journal of the Endocrine Society

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show abstract

“…Therefore unsurprisingly, we did not observe associations between sex hormone levels and RFO. Previous studies also questioned the relationship between E2 levels and RFO in premenopausal [41] and postmenopausal women [42].…”

Section: Sex Hormone Profile and Resting Fat Oxidationmentioning

confidence: 99%

Associations of resting and peak fat oxidation with sex hormone profile and blood glucose control in middle-aged women

Karppinen

Juppi

Hintikka

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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Overweight postmenopausal women with different plasma estradiol concentrations present with a similar pattern of energy expenditure and substrate oxidation rate before and after a fatty meal challenge

Cited by 2 publications

References 37 publications

Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys

Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys

Associations of resting and peak fat oxidation with sex hormone profile and blood glucose control in middle-aged women

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