Associations of resting and peak fat oxidation with sex hormone profile and blood glucose control in middle-aged women

Karppinen, Jari E; Juppi, Hanna-Kaarina; Hintikka, Jukka; Wiklund, Petri; Haapala, Eero A.; Hyvärinen, Matti; Tammelin, Tuija; Kujala, Urho M.; Laukkanen, Jari A.; Laakkonen, Eija K.

doi:10.1016/j.numecd.2022.06.001

Cited by 4 publications

(3 citation statements)

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“…The data has been partly used in an earlier validation study ( 21 ). The Estrogen and microRNAs as Modulators of Women's Metabolism study (EsmiRs; 2019-2020) examined resting and exercise metabolism in middle-aged women ( 22 ), and we included all 42 participants with measured REEs from that study. The Physique study ( 23 ) investigated the effects of competition weight loss in normal-weight participants; here, we used the baseline data from 23 young women collected before their weight loss.…”

Section: Methodsmentioning

confidence: 99%

Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure

Karppinen

Wiklund²,

Ihalainen

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass–adjusted resting energy expenditure (REEadj). Objectives We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and follicle-stimulating hormone concentrations explain REEadj in midlife. Methods We divided 120 women, including 16 mother–daughter pairs, into age groups; group I (n=26) consisted of participants aged 17–21, group II (n=35) of those aged 22–38 and group III (n=59) of those aged 41–58 years. The women in group III were further categorized as pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays. Results The REEadj of group I was 126 kcal/d (95% CI: 93–160) higher than that of group III, and the REEadj of group II was 88 kcal/d (95% CI: 49–127) higher. Furthermore, daughters had a 100 kcal/d (95% CI: 63–138 kcal/d) higher REEadj than their middle-aged mothers (all P<0.001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations. Conclusions We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline.

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Section: Methodsmentioning

confidence: 99%

Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure

Karppinen

Wiklund²,

Ihalainen

et al. 2023

The Journal of Clinical Endocrinology &Amp; Metabolism

Self Cite

View full text Add to dashboard Cite

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“…The data has been partly used in an earlier validation study (21). The EsmiRs study (Estrogen and microRNAs as Modulators of Women's Metabolism, 2019-2020) examined resting and exercise metabolism in middle-aged women (22), and we included all 42 participants with measured REEs from that study. The Physique study (2019, Isola et al unpublished) investigated the effects of competition weight loss in normal-weight participants as earlier (23); here, we used the baseline data from 23 young women collected before their weight loss.…”

Section: Participantsmentioning

confidence: 99%

“…The data has been partly used in an earlier validation study (21). The EsmiRs study (Estrogen and microRNAs as Modulators of Women's Metabolism, 2019-2020) examined resting and exercise metabolism in middle-aged women (22), and we included all 42 participants with measured REEs from that study. The Physique study (23) and started to decline at 63.0 years (95% CI: 60.1-65.9) (1).…”

Section: Participantsmentioning

confidence: 99%

Age but not menopausal status is linked to lower resting energy expenditure

Karppinen

Wiklund²,

Ihalainen

et al. 2022

Preprint

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Background: Uncertainty remains whether ageing before late adulthood and menopause reduce fat-free mass and fat mass-adjusted resting energy expenditure (REEadj). We therefore investigated whether REEadj differs 1) between middle-aged and younger women and 2) in middle-age by menopause status. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether oestradiol and follicle-stimulating hormone concentrations or body fat percentage explain REEadj in midlife. Methods: We divided 120 women, including 16 mother–daughter pairs, into age groups. Group I (n=26) consisted of participants aged 17-21, group II (n=35) aged 22–38 and group III (n=59) aged 41-58 years. Group III women were pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays. Results: Group I had 126 kcal/d (95% confidence interval [CI], 93–160; P<0.001) higher REEadj than group III, while group II had 88 kcal/d (CI, 49-127; P<0.001) higher REEadj. Furthermore, the daughters had 100 kcal/d (CI, 63-138; P<0.001) higher REEadj than their mothers. In group III, REEadj did not differ by menopause status, but body fat percentage was positively associated with REEadj (beta=0.39, P=0.003). Conclusions: We demonstrated that REE declines with age in women before late adulthood, even when controlling for body composition and partially for genetic background, and that menopause does not contribute to the decline in REEadj. Menopause-associated fat accumulation may actually elevate REEadj.

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