Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure

Abstract

Context It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass–adjusted resting energy expenditure (REEadj). Objectives We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and follicle-stimulating hormone concentrations explain REEadj in midlife. Methods We divided 120 women, including 16 mother–daughter pairs, into age groups; group I (n=26) consisted of participants aged 17–21, group II (n=35) of those aged 22–38 and group III (n=59) of those aged 41–58 years. The women in group III were further categorized as pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays. Results The REEadj of group I was 126 kcal/d (95% CI: 93–160) higher than that of group III, and the REEadj of group II was 88 kcal/d (95% CI: 49–127) higher. Furthermore, daughters had a 100 kcal/d (95% CI: 63–138 kcal/d) higher REEadj than their middle-aged mothers (all P<0.001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations. Conclusions We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline.

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“…Regardless, our results suggest a decrease in basal energy expenditure may contribute to the increased body mass caused by OVX. The exact mechanisms are somewhat vague, and we are also uncertain of how well these data translate to humans, since whether menopause directly leads to reduced basal energy expenditure in middle-aged women remains unknown [33].…”

“…The exact mechanisms are somewhat vague, and we are also uncertain of how well these data translate to humans, since whether menopause directly leads to reduced basal energy expenditure in middle-aged women remains unknown [33].…”

“…Menopause is widely believed to reduce energy expenditure [31], even though recent literature challenges this topic [32,33]. At cellular level, the amount and efficiency of mitochondria and uncoupling proteins (UCP) play the main role in thermogenesis, and hence, contribute to energy expenditure [34].…”