Overweight, Obesity, and Depression

Luppino, Floriana S.; Wit, Leonore de; Bouvy, Paul F.; Stijnen, Theo; Cuijpers, Pim; Penninx, Brenda W. J. H.; Zitman, Frans G.

doi:10.1001/archgenpsychiatry.2010.2

Cited by 3,315 publications

(1,599 citation statements)

References 64 publications

(115 reference statements)

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“…47 Fourth, as stated previously, oxidative stress and inflammatory markers could play an important part in mediating the association between physical performance and depression, but were not assessed in our research. Fifth, due to missing data and excluding participants who were already depressed, the current data also represent some selection and survival bias.…”

Section: Discussionmentioning

confidence: 78%

Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study

Veronese

Stubbs

Trevisan³

et al. 2017

Physical Therapy

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Section: Discussionmentioning

confidence: 78%

Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study

Veronese

Stubbs

Trevisan³

et al. 2017

Physical Therapy

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“…Thus, if there is a prospective relationship among people with psychopathology, the direction from psychopathology to metabolic dysregulation may be stronger. It is possible that the lack of association may be partly due to the overall good health of the sample, with previous findings demonstrating stronger associations between obesity and depression than overweight and depression 62, 63. It may also be partly due to the sample composition, which at baseline largely consisted of people with high psychopathology symptoms who decrease in their symptoms over time as a consequence of treatment or naturalistic change.…”

Section: Discussionmentioning

confidence: 94%

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

et al. 2016

Self Cite

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BackgroundMetabolic syndrome components—waist circumference, high‐density lipoprotein cholesterol (HDL‐C), triglycerides, systolic blood pressure and fasting glucose—are cross‐sectionally associated with depression and anxiety with differing strength. Few studies examine the relationships over time or whether antidepressants have independent effects.MethodsParticipants were from the Netherlands Study of Depression and Anxiety (NESDA; N = 2,776; 18–65 years; 66% female). At baseline, 2‐ and 6‐year follow‐up, participants completed diagnostic interviews, depression and anxiety symptom inventories, antidepressant use assessment, and measurements of the five metabolic syndrome components. Data were analyzed for the consistency of associations between psychopathology indicators and metabolic syndrome components across the three assessment waves, and whether psychopathology or antidepressant use at one assessment predicts metabolic dysregulation at the next and vice versa.ResultsConsistently across waves, psychopathology was associated with generally poorer values of metabolic syndrome components, particularly waist circumference and triglycerides. Stronger associations were observed for psychopathology symptom severity than diagnosis. Antidepressant use was independently associated with higher waist circumference, triglycerides and number of metabolic syndrome abnormalities, and lower HDL‐C. Symptom severity and antidepressant use were associated with subsequently increased number of abnormalities, waist circumference, and glucose after 2 but not 4 years. Conversely, there was little evidence that metabolic syndrome components were associated with subsequent psychopathology outcomes.ConclusionsSymptom severity and antidepressant use were independently associated with metabolic dysregulation consistently over time and also had negative consequences for short‐term metabolic health. This is of concern given the chronicity of depression and anxiety and prevalence of antidepressant treatment.

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“…Depressive symptoms have been shown to be associated with smoking,28 medication noncompliance,29 and physical inactivity30 as well as diabetes,31 obesity,32 hypertension,33 and inflammation 34. We added to the literature by demonstrating that these factors and others such as antidepressant use35 and corrected QT interval36 do not appear to fully explain the association between depressive symptoms and incident CVD death and stroke in otherwise healthy persons.…”

Section: Discussionmentioning

confidence: 99%

Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study

Moise

Khodneva

Richman

et al. 2016

JAHA

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BackgroundDepression is a relapsing and remitting disease. Prior studies on the association between depressive symptoms and incident cardiovascular disease (CVD) have been limited by single measurements, and few if any have examined both incident coronary heart disease and stroke in a large biracial national cohort. We aimed to assess whether time‐dependent depressive symptoms conferred increased risk of incident CVD.Methods and ResultsBetween 2003 to 2007, 22 666 black and white participants (aged ≥45 years) without baseline CVD in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were recruited. Cox proportional hazards regression analyses assessed the association between up to 3 measurements of elevated depressive symptoms (4‐item Center for Epidemiologic Studies Depression Scale score ≥4) and incident coronary heart disease, stroke, and CVD death adjusting for age, sex, region, income, health insurance, education, blood pressure, cholesterol, medication, obesity, diabetes mellitus, kidney disease, C‐reactive protein, corrected QT interval, atrial fibrillation, left ventricular hypertrophy, smoking, alcohol, physical inactivity, medication adherence, and antidepressant use. The participants’ average age was 63.4 years, 58.8% were female, and 41.7% black. Time‐varying depressive symptoms were significantly associated with CVD death (adjusted hazard ratio 1.30, 95% CI 1.04–1.63), with a trend toward significance for fatal and nonfatal stroke (adjusted hazard ratio 1.26, 95% CI 0.99–1.60) but not fatal and nonfatal coronary heart disease (adjusted hazard ratio 1.11, 95% CI 0.89–1.38). Race did not moderate the association between depressive symptoms and CVD.ConclusionsProximal depressive symptoms were associated with incident fatal and nonfatal stroke and CVD death even after controlling for multiple explanatory factors, further supporting the urgent need for timely management of depressive symptoms.

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Overweight, Obesity, and Depression

Abstract: This meta-analysis confirms a reciprocal link between depression and obesity. Obesity was found to increase the risk of depression, most pronounced among Americans and for clinically diagnosed depression. In addition, depression was found to be predictive of developing obesity.

Cited by 3,315 publications

References 64 publications

Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study

Poor Physical Performance Predicts Future Onset of Depression in Elderly People: Progetto Veneto Anziani Longitudinal Study

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study

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