Overweight, Obesity, and Body Composition in 3.5- and 7-Year-Old Swedish Children Born with Marginally Low Birth Weight

Lindberg, Josefine; Norman, Mikael; Westrup, Björn; Öhrman, Tove; Domellöf, Magnus; Berglund, Staffan

doi:10.1016/j.jpeds.2015.08.045

Cited by 17 publications

(20 citation statements)

References 36 publications

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“…In the present study, we explored the largest group of LBW children (2000–2500 g) and used several validated laboratory markers considered important for the future risk of developing metabolic syndrome, diabetes and cardiovascular disease. While we in our previous studies of overweight and body composition in these children, failed to show any increased risk in the marginally LBW cohort [13], the present may indicate that the children born with marginally LBW, and especially those born SGA, have signs of altered insulin and glucose homeostasis, already at 7 years of age.…”

Section: Discussioncontrasting

confidence: 66%

“…We recently explored growth and body composition in a cohort of 281 marginally LBW children compared to a group of children born with normal birth weight (NBW, 2501–4500 g), and found that the risk of overweight and obesity at 7 years of age did not differ between the two groups. In fact, the marginally LBW children had lower body mass index (BMI) as well as lower fat mass and they were more likely to remain underweight or short compared to NBW children [13, 14]. In the present study, we explored the same cohort regarding their laboratory markers of cardiometabolic risk.…”

Section: Introductionmentioning

confidence: 99%

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Cardiometabolic risk factors in children born with marginally low birth weight: A longitudinal cohort study up to 7 years-of-age

et al. 2019

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Introduction Low birth weight (LBW, <2500 g) may predict an increased risk of an adverse cardiometabolic profile later in life, but long-term effects in different populations and birth weight strata are still unclear. We explored laboratory markers of cardiometabolic risk in children born with marginally LBW (2000–2500 g). Methods This was a prospective longitudinal cohort study including 285 Swedish marginally LBW children and 95 normal birth weight (NBW, 2501–4500 g) controls. At 3.5 and 7 years of age, blood samples for glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), cholesterol, triglycerides, high- and low density lipoprotein (HDL and LDL), apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) were assessed and compared between the groups. Results No significant differences in levels of insulin, HOMA-IR, hs-CRP or blood lipids were observed between marginally LBW and NBW children. At 7 years there was a higher proportion of marginally LBW children with elevated levels of insulin, defined as above the 90 th percentile of the control group (21% vs 8.6%, p = 0.038). This association was, however, confounded by maternal ethnicity. In marginally LBW children born small for gestational age (SGA), mean fasting glucose was significantly higher compared to controls (4.7 vs 4.5 mmol/L, p = 0.020). Conclusions There were no significant differences in insulin, insulin resistance, hs-CRP or blood lipids between the marginally LBW children and controls. The subgroup of marginally LBW children born SGA may present early signs of glucose imbalance already at school age.

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Section: Discussioncontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Cardiometabolic risk factors in children born with marginally low birth weight: A longitudinal cohort study up to 7 years-of-age

et al. 2019

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“…The association between ASD and overweight/obesity is thought to be affected by multiple etiological factors that may have contributed to the severe heterogeneity we observed even after controlling for the methodological variability. These potential etiological factors include genetic variants (eg, 16p11.2 deletion and microdeletion 11p14.1); prenatal exposure to certain infections, medications, toxins, maternal diabetes, and maternal obesity; intra‐uterine growth retardation; and prematurity . Furthermore, limitations associated with ASD (eg, food selectivity and physical limitations) and management of ASD per se (eg, atypical antipsychotics) could be mediating or moderating the association.…”

Section: Discussionmentioning

confidence: 99%

The risk of overweight and obesity in children with autism spectrum disorders: A systematic review and meta‐analysis

et al. 2019

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Multiple studies have suggested that autism spectrum disorders seem to increase the risk of overweight and obesity. We examined the pooled prevalence and relative risk of developing overweight or obesity among children with autism spectrum disorders in a systematic review and meta-analysis. We searched PubMed, Scopus, ProQuest, and Web of Science databases and subsequently screened the records to identify studies that reported prevalence of overweight and/or obesity in children with ASD and matched groups of neurotypical children. DerSimonian-Laird random-effects meta-analyses were performed to examine pooled prevalence and relative risk of obesity in children with autism spectrum disorders using the "meta" package in R software. Among children with autism spectrum disorders, the prevalence of obesity was 22.2%. Children with ASD had a 41.1% greater risk (P = .018) of development of obesity. Non-Caucasian race, increasing age, female sex, and living in the United States emerged as positive moderators of the association between autism spectrum disorders and prevalence of overweight or obesity.Autism spectrum disorders seem to increase the risk of childhood obesity.Increased awareness of this association may allow the implementation of early interventions to reduce obesity and prevent potential deterioration of quality-oflife in this population.

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“…The longitudinal study of Lindberg et al presented no significant differences between children with normal or low birth weight with respect to the prevalence of overweight/obesity; however, at the age of 3.5 years, the mean body height, body weight, and BMI in the children with marginally low birth weight were lower compared to the children in the control group [21].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Children’s Birth Weight and Birth Length and a Risk of Overweight and Obesity in 4–15-Year-Old Children

et al. 2019

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Background and Objectives. The purpose of the study was to investigate the relationship between children’s birth weight/length and a risk of overweight and obesity. Materials and Methods. The study involved 747 children from kindergartens, as well as primary and middle schools from southeastern Poland. All the subjects were examined on fasting status. Each child was examined for body mass and height, in order to calculate their body mass index (BMI), and BMI centile. The parents completed a questionnaire related to basic information about the child and the family. Results. In the study group, the male infants presented greater birth body weight and birth body length. A comparison of the distribution of birth weights and lengths between the children with normal BMI and with high BMI showed statistically significant differences only in the case of birth length of 12–15-year-old children and in the group of boys aged 12–15 years. In the case of the female children and the group of 7–11-year-olds a statistically significant difference was found in the BMI centile at a later age—a higher centile was found in the girls and in the children aged 7–11 years classified as adequate for gestational age (AGA). Conclusions. Birth body weight is positively related to BMI centile; however, no significant differences were found in birth weight between children with overweight/obesity and children with normal body weight. Birth length is associated with a lower BMI centile only in boys aged 12–15 years, and lower birth length is found in boys with overweight and obesity.

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Overweight, Obesity, and Body Composition in 3.5- and 7-Year-Old Swedish Children Born with Marginally Low Birth Weight

Cited by 17 publications

References 36 publications

Cardiometabolic risk factors in children born with marginally low birth weight: A longitudinal cohort study up to 7 years-of-age

Cardiometabolic risk factors in children born with marginally low birth weight: A longitudinal cohort study up to 7 years-of-age

The risk of overweight and obesity in children with autism spectrum disorders: A systematic review and meta‐analysis

Relationship between Children’s Birth Weight and Birth Length and a Risk of Overweight and Obesity in 4–15-Year-Old Children

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