Overweight and obesity add to behavioral problems in children with sleep-disordered breathing

Biggs, Sarah Nichole; Tamanyan, Knarik; Walter, Lisa M.; Weichard, Aidan; Davey, Margot J; Nixon, Gillian M.; Horne, Rosemary Sylvia Claire

doi:10.1016/j.sleep.2017.09.001

Cited by 17 publications

(12 citation statements)

References 34 publications

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“…Obesity is also a major risk factor for obstructive sleep apnea. In a recent study, obesity and overweight comorbid with obstructive sleep apnea increased the risk of externalizing behaviors such as aggression [32]. Neuroimaging studies have documented lower perfusion in the orbitofrontal cortex, medial/ventrolateral prefrontal cortex, and middle/superior frontal gyri in impulsive and obese individuals [33], showing this obesity-impulsivity connection.…”

Section: Discussionmentioning

confidence: 95%

Insomnia symptoms and obesity are associated with aggression independent of depression in patients with epilepsy

Lee

Kim

et al. 2020

Seizure

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There has been little research conducted into aggression in persons with epilepsy (PWE). We determine whether sleep disturbances and obesity are associated with aggression in PWE independent of psychological distress. Methods: : This was a cross-sectional study. The Aggression Questionnaire (AQ-K), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), the Patient Health Questionnaire-9 (PHQ-9), and the Generalized Anxiety Disorder-7 (GAD-7) were utilized in the study. A stepwise linear regression analysis was used. Results: : A total of 104 participants (49% men) were included. Mean AQ-K score was 51.4 (SD 12.6). PHQ-9 scores ≥10 and GAD-7 scores ≥7 were noted in 26.9% and 24.0% of participants, respectively. In a stepwise linear regression model, AQ-K scores were positively associated with PHQ-9 scores ≥10 (p = 0.002), ISI scores (p = 0.007), body mass index (BMI) (p = 0.001), and composite scores of epilepsy severity (p = 0.013). This model explained 46.6% of the variance in the AQ-K. In the subscale analyses, different variables were identified as independent factors associated with different subscales of the AQ-K. For example, physical aggression was related to a PHQ-9 score ≥10, men, and perampanel usage, whereas hostility was related to a GAD-7 score ≥7, polytherapy, and BMI. Conclusions: : Insomnia symptoms and obesity were related to overall aggressive behavior in PWE independent of depressive symptoms. The individual subscales of the AQ were correlated differently with the various factors including male sex, obesity, depressive symptoms, anxiety, insomnia symptoms, epilepsy severity, polytherapy, and the use of perampanel.

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Section: Discussionmentioning

confidence: 95%

Insomnia symptoms and obesity are associated with aggression independent of depression in patients with epilepsy

Lee

Kim

et al. 2020

Seizure

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“…9 An enduring pattern of disrupted sleep is associated with maladaptive neurocognitive, behavioural, and emotional changes. [10][11][12] Further, OSAS in childhood activates inflammatory mechanisms similar to those observed with obesity. 2,13 Therefore, in combination obesity and OSAS may have negative synergic inflammatory effects, in addition to the shared adverse cardio-metabolic consequences.…”

Section: Introductionmentioning

confidence: 90%

Polysomnographic comparison of sleep in children with obesity and normal weight without suspected sleep‐related breathing disorder

et al. 2021

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Short sleep and obstructive apneas/hypopneas have been shown to be associated with childhood obesity. Still, few studies have compared sleep in children with obesity, without suspected sleep disordered breathing and normal weight peers by objective sleep measures and compared results with subjective parent assessment of sleep. Children with obesity aged 7-13 years (N = 44) and a matched group of normal weight children (N = 42) completed clinical polysomnography (Embla A10 Recording System). Parents scored their children's sleep on the Children's Sleep Habits Questionnaire (CSHQ). Mann-Whitney U tests were used to compare groups. There was a higher obstructive apnea/hypopnea index (AHI) (median obesity = 1.20 vs. median normal = 0.66; z = À1.33, U = 560.50, p = 0.002) and number of oxygen desaturation events per hour (median obesity = 0.7 vs. median normal = 0.2; z = À3.45, U = 402.50, p = 0.001) in the children with obesity compared to children with normal weight. The children with obesity had a significantly longer sleep duration (median obesity 8:50 h = vs. median normal = 8:32 h; z = À2.05, U = 687.00, p = 0.041), longer stage N2 sleep (median obesity = 87 min vs. median normal = 52 min; z = À2.87, U = 576.50, p = 0. 004) and shorter REM sleep (median obesity = 94 min vs. median normal = 121 min; z = 5.05, U = 1477.00, p ≤ .001). No differences were observed for time in sleep stage N1 and N3, wake time after sleep onset or the total arousal index . Further, no group differences were found on the CSHQ sleep-disordered breathing sub-scale (p = 0.399). The children with obesity demonstrated significantly more mild to moderate sleep disordered breathing than children with normal weight, although this was not corroborated by parent report.

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“…So far, current studies on the association of snoring and obesity have focused primarily on men and children [3,14], while underrepresented women. In addition, any association between snoring and body composition in menopausal women has received little attention.…”

Section: Introductionmentioning

confidence: 99%

“…Snoring, the manifestation of increased upper airway resistance, is commonly regarded as a reliable proxy marker of obstructive sleep apnea (OSA) [ 1 , 2 ]. Moreover, regular snoring has been suggested to be correlated with obesity [ 3 ], hypertension [ 4 ] and diabetes mellitus [ 5 ]. OSA is supposed to be more prevalent in men than women, however the gap was narrowed when women approach menopause [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association of snoring and body composition in (peri-post) menopausal women

Zhou

Liu

et al. 2020

BMC Women's Health

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Background: Little attention has been paid to whether snoring frequency is associated with body composition in menopausal women, particularly in China. This study objected to investigate the association between self-reported snoring and body composition in (peri-post) menopausal Chinese women as well as metabolic indicators. Methods: This cross-sectional study enrolled 715 participants aged 40-67 years from the Menopause Clinic in the Shanghai Sixth People's Hospital. Participants were categorized into four subgroups stratified by self-reported snoring frequency: never, rarely (< 1 night per week), occasionally (1-2 nights per week), regularly (≥3 nights per week), while body composition was measured using bioelectrical impedance analysis (BIA). Besides, blood sample were collected to test the glycolipid indicators. Results: In our sample of investigation, regular snoring (≥3 nights per week) was found to be an independent risk factor for higher fat mass (total, upper limbs, trunk), with the highest risk of 2.4 times for fat mass of trunk after adjusting for metabolic confounders(p = 0.003). Meanwhile, regular snoring was independently associated with higher fat mass (total and each segment) only in menopausal transition (p = 0.023). Conclusions: We suggested that self-reported regular snoring may be taken as a simple alternative to predict higher fat mass (≥17.11 kg, upper quartile) in menopausal women. Similarly, body composition should be attached to the great importance to those who in menopausal transition in order to help to prevent obstructive sleep apnea (OSA).

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Overweight and obesity add to behavioral problems in children with sleep-disordered breathing

Cited by 17 publications

References 34 publications

Insomnia symptoms and obesity are associated with aggression independent of depression in patients with epilepsy

Insomnia symptoms and obesity are associated with aggression independent of depression in patients with epilepsy

Polysomnographic comparison of sleep in children with obesity and normal weight without suspected sleep‐related breathing disorder

Association of snoring and body composition in (peri-post) menopausal women

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