Overview of Wound Healing in Different Tissue Types

Stroncek, John; Reichert, M. Shawn

doi:10.1201/9781420009309.pt1

Cited by 72 publications

(133 citation statements)

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“…Although inflammatory response plays a crucial role in bone regeneration, prolonged and/or exaggerated inflammation is harmful and retards the bone healing process [Stroncek and Reichert, 2008]. Also, the precise effects of innate and adaptive immune systems and their products on bone healing, especially for temporal and spatial patterns, remain unclear.…”

Section: Mscs and Immunomodulatory Effectsmentioning

confidence: 99%

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Oryan

Kamali²,

Moshiri³

et al. 2017

Cells Tissues Organs

285

204

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Healing and regeneration of bone injuries, particularly those that are associated with large bone defects, are a complicated process. There is growing interest in the application of osteoinductive and osteogenic growth factors and mesenchymal stem cells (MSCs) in order to significantly improve bone repair and regeneration. MSCs are multipotent stromal stem cells that can be harvested from many different sources and differentiated into a variety of cell types, such as preosteogenic chondroblasts and osteoblasts. The effectiveness of MSC therapy is dependent on several factors, including the differentiating state of the MSCs at the time of application, the method of their delivery, the concentration of MSCs per injection, the vehicle used, and the nature and extent of injury, for example. Tissue engineering and regenerative medicine, together with genetic engineering and gene therapy, are advanced options that may have the potential to improve the outcome of cell therapy. Although several in vitro and in vivo investigations have suggested the potential roles of MSCs in bone repair and regeneration, the mechanism of MSC therapy in bone repair has not been fully elucidated, the efficacy of MSC therapy has not been strongly proven in clinical trials, and several controversies exist, making it difficult to draw conclusions from the results. In this review, we update the recent advances in the mechanisms of MSC action and the delivery approaches in bone regenerative medicine. We will also review the most recent clinical trials to find out how MSCs may be beneficial for treating bone defects.

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Section: Mscs and Immunomodulatory Effectsmentioning

confidence: 99%

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Oryan

Kamali²,

Moshiri³

et al. 2017

Cells Tissues Organs

285

204

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show abstract

“…The cells and extracellular matrix (ECM) within the lesion core of a mature CNS wound are non-functional from a neurological perspective [24,25,34]. If no exacerbating factors are present, the collection of fibrotic cells and ECM can promote neovascular and brain parenchymal remodeling [24] thus reducing the long-term impact of the injury [35].…”

Section: In Vivo Responses To Traumatic Brain Injurymentioning

confidence: 99%

“…Wound formation, tissue repair, and tissue regeneration within the CNS, like other tissues consists of three major phases, 1) cell death and inflammation 2) tissue replacement and 3) tissue remodeling [24,25] (see Fig. 2).…”

Section: In Vivo Responses To Traumatic Brain Injurymentioning

confidence: 99%

A critical review of cell culture strategies for modelling intracortical brain implant material reactions

et al. 2016

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“…The socket contracture formed fibrotic tissue and granulation due to chronic irritation, one of which due to friction of the prosthesis with the socket, resulted in impairment of wound healing process [5,6]. The formation of hypertrophic scars that dominates the socket contracture tissue is a deviation of wound healing in the form of hyperactivity of fibroblast, excessive formation of myofibroblasts and extracellular matrix (ECM) deposition [7,8] TGF-β plays roles in all phases of eye wound healing process by increasing growth factor secretion involved in cell migration, proliferation, ECM deposition and myofibroblast formation.…”

Section: Introductionmentioning

confidence: 99%

α-SMA Expression Increased Over Cell Passages and Decreased by Exogenous TGF-β1, In Vitro Studies on Myofibroblast Derived from Orbital Socket Contracture

Dewi

Chairinnisa²,

Sujuti³

et al. 2018

J.Trop.Life.Science

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ABSTRACTα-smooth muscle actin (α-SMA), a marker of myofibroblast, induces cytoskeleton reorganization, increases contractility and stimulates cell migration in TGF-β1 induced stress fibers. The aims of the present study were to determine the level of α-SMA expression and morphological cell changes in different passages of myofibroblasts with varied TGF-β1 concentrations. Myofibroblast cell cultures were derived from fibrotic tissues of fourth degree socket contracture. The α-SMA expression level was measured in myofibroblast cultures passage I, II, and III with and without 10 ng/mL TGF-β1, and in passage III with 2.5; 5; 10; and 20 ng/mL TGF-β1. Results: The levels of α-SMA expression level in passage I to III were I 31.42 ± 3.4; 40.34 ± 8.14 and 56.37 ± 7.57, respectively. Addition of 10 ng/mL TGF-β1 into passage I-III myofibroblast cultures resulted in α-SMA expression level of 31.24 ± 2.93; 36.81 ± 6.09; and 14.29 ± 2.72, respectively. Myoblasts passage III showed the lowest α-SMA expression level following exposure to TGF-β1 10 ng/mL (22.37 ± 12.86) and highest without TGF-β1 (48.34 ± 13.36), however no morphological changes detected. α-SMA expression level increased with cell passages, decreases with addition of TGF-β1 while not affecting morphology of myofibroblast derived from the orbital socket contracture.

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Overview of Wound Healing in Different Tissue Types

Cited by 72 publications

References 0 publications

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

A critical review of cell culture strategies for modelling intracortical brain implant material reactions

α-SMA Expression Increased Over Cell Passages and Decreased by Exogenous TGF-β1, In Vitro Studies on Myofibroblast Derived from Orbital Socket Contracture

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