Overview of the development of a visual based automated bio-micromanipulation system

Ouyang, P. R.; Zhang, W.J.; Gupta, Madan M.; Zhao, Wei

doi:10.1016/j.mechatronics.2007.06.002

Cited by 75 publications

(30 citation statements)

References 7 publications

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“…Future challenges include the powering and steering technology for microrobots inside the body, how to detect, localize and communicate with microrobots inside the body, how to make and integrate on-board diagnostic and therapeutic tools, and how to program and control armies of microrobots (as this will be necessary if such robots are to treat large areas of the body) [44]. The other type of microrobot is a large robot that can be used to manipulate single cells, often called a micromanipulator [45]. Since the pioneer work of Sun and Nelson [46], a number of automated robotic system have been developed for diverse applications at the single-cell level, including capture, immobilization, deposition, patterning and injection of cells [47], [48], greatly promoting the applications of microrobotic systems in biology and medicine.…”

Section: Blueprint Of Micro/nano Automation In Personalized Cancementioning

confidence: 99%

Applications of Micro/Nano Automation Technology in Detecting Cancer Cells for Personalized Medicine

Liu

et al. 2017

IEEE Trans. Nanotechnology

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Abstract-The coming era of personalized cancer treatment is presenting automation with unprecedented opportunities. Currently, the drug susceptibility test of clinical cancer patients is mainly dependent on manual labor with a low level of automation. Automating the process of primary cancer cell detection will potentially have tremendous economic benefits and social significance. Automated cancer cell detection means developing robotic and automation equipments to handle single cells and molecules at the micro/nanometer-scale. The achievements of information science, engineering technology, life sciences, and nanotechnology in the past decades have led to the birth of robots that can perform effective manipulations on single living cells at the micro/nanometerscale in aqueous conditions, opening the door to automated cancer cell detection. However, there is still a huge gap between current single-cell micro/nano automation technology and clinical requirements for personalized medicine. In this paper, we will review the progress of single-cell micro/nano automation technology in recent years and discuss the facing challenges and future directions in three aspects, including automated cell isolation and delivery, automatically acquiring the physiological features of cells and data analysis.

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Section: Blueprint Of Micro/nano Automation In Personalized Cancementioning

confidence: 99%

Applications of Micro/Nano Automation Technology in Detecting Cancer Cells for Personalized Medicine

Liu

et al. 2017

IEEE Trans. Nanotechnology

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“…Several liquid-handling robots are developed to ease the manpower and time-consuming screening task and can accurately dispense volumes as small as 50 nL [7]. Nevertheless, their high cost and complexity make them inaccessible to the vast majority of researchers [8].…”

Section: Introductionmentioning

confidence: 99%

Research on Concanavalin A Crystallization in a Flow-Free Droplet-Based Device

Du¹,

Zhang²,

Ji³

et al. 2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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Abstract. Protein crystallography is a very critical process that limits the development of pharmaceutical engineering. Microfluidic technology has provided an opportunity for protein crystallization. In this paper, a flow-free droplet-based device is presented for producing highly controlled crystals and fabrication of this device with polydimethylsiloxane (PDMS) is presented. The experiment was performed on the device and shows that the crystals of Con A and protein ligand (DK3) have a spherical structure.

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“…Micro/nano positioning platforms play an increasingly important role in the domains of mechanics, biology, materials, physics and chemistry. Typical applications touch lithography, scanning probe microscopy, space flexible manipulators, ultra-precision machine tools and so on [3][4][5][6]. Piezoelectric actuators (PEAs) are widely applied in micro/nano positioning platforms, because of their high hardness, fast response and other outstanding features.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Control of Piezoelectric Actuators

Chi

2014

International Journal of Advanced Robotic Systems

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The micro/nano positioning field has made great progress towards enabling the advance of micro/nano technology. Micro/nano positioning stages actuated by piezoelectric actuators are the key devices in micro/nano manipulation. The control of piezoelectric actuators has emerged as a hot topic in recent years. Piezoelectric materials have inherent hysteresis and creep nonlinearity, which can reduce the accuracy of the manipulation, even causing the instability of the whole system. Remarkable efforts have been made to compensate for the nonlinearity of piezoelectric actuation through the mathematical modelling and control approaches. This paper provides a review of recent advances on the control of piezoelectric actuators. After a brief introduction of basic components of typical piezoelectric micro/nano positioning platforms, the working principle and modelling of piezoelectric actuators are outlined in this paper. This is followed with the major control method and recent progress is presented in detail. Finally, some open issues and future work on the control of piezoelectric actuators are extensively discussed.

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Overview of the development of a visual based automated bio-micromanipulation system

Cited by 75 publications

References 7 publications

Applications of Micro/Nano Automation Technology in Detecting Cancer Cells for Personalized Medicine

Applications of Micro/Nano Automation Technology in Detecting Cancer Cells for Personalized Medicine

Research on Concanavalin A Crystallization in a Flow-Free Droplet-Based Device

Recent Advances in the Control of Piezoelectric Actuators

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