Overview of the clinical and imaging features of the most common non-rhabdomyosarcoma soft-tissue sarcomas

Kao, Simon C.

doi:10.1007/s00247-019-04427-z

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…Greater than 15% of patients have metastatic disease on presentation, with the most common site being the lungs, thus staging imaging must include radiographic analysis of the chest [8]. 2-[ 18 F]fluoro-2-deoxy-d-glucose (FDG) PET has become an increasingly attractive staging modality, although its utility as a surveillance tool remains unclear [8,9]. This should be followed by a core or surgical biopsy to obtain adequate tissue for histologic, molecular, and cytogenic analysis [8,10].…”

Section: Discussionmentioning

confidence: 99%

Complex management of a large retroperitoneal undifferentiated sarcoma encasing the abdominal aorta in a pediatric patient: a case report and review

et al. 2023

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Background Retroperitoneal undifferentiated sarcomas are rare, highly aggressive mesenchymal tumors with limited available treatment options. Surgical resection ± chemoradiation remains standard of care. However, in unique cases, challenging tumor biology, advanced tumor stage, and the morbidity required of an R0 resection can prohibit management and ultimate cure. Targeted therapies have an increasing role in this setting due to advances in molecular analytics. Case presentation Herein, we describe the management of an 11-year-old female with a chemotherapy-refractory large retroperitoneal sarcoma encasing the infrarenal aorta with a large acquired aortic pseudoaneurysm. This is the first report describing the complex approach to a retroperitoneal NTRK-fusion ( +) undifferentiated sarcoma confounded by an acquired aortic pseudoaneurysm in a pediatric patient. Preoperative considerations, intra-operative technique, postoperative management, adjuvant therapies and a brief review of the literature are discussed. Conclusion Overall, a holistic understanding of the tumor biology and a cohesive multidisciplinary approach is integral to the care and long-term management of these cases.

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Section: Discussionmentioning

confidence: 99%

Complex management of a large retroperitoneal undifferentiated sarcoma encasing the abdominal aorta in a pediatric patient: a case report and review

et al. 2023

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“…Plain radiographs usually does not reveal much but can show re-modelling, bone invasion or calcification of the soft tissue. [10][11][12] Radiographs may show mineralization within the lesion in up to twenty-five percent of cases. The mineralization is spotty and resembles heterotopic ossification.…”

Section: Discussionmentioning

confidence: 99%

A flap graft technique for the reconstruction of extensor mechanism of the knee in a case of peri-articular synovial sarcoma managed by limb salvage

Giriraj

Kumar

et al. 2023

Int J Res Orthop

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Synovial sarcoma is a malignant soft tissue tumour arising from the primitive mesenchymal cells which has a delayed progression has a slow progression and often mis-diagnosed. A fifty-two years old female presented with complaint of swelling, pain and inability to move her left knee for three years duration. Presented with recurrence for which Wide excision of the tumour, with reconstruction of knee using custom mega-prosthesis and extensor mechanism reconstruction was done. Patient had a good functional outcome and no recurrence.

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“…Histologically, SS may be composed of spindle cells alone, or epithelial and spindle cells combined. Diagnosis of SS is based on the presence of a t(X;18)(p11;q11) translocation on tissue genomics 14 . Magnetic resonance imaging of SS can be deceptively benign appearing.…”

Section: Malignant Soft Tissue Tumors (Mstt)mentioning

confidence: 99%

Lumps and bumps: What not to miss

Levin

Kinariwalla

Behr

et al. 2022

Pediatric Dermatology

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The evaluation of pediatric patients with subcutaneous nodules remains a diagnostic challenge. Pediatric dermatologists are regularly confronted with patients who have a nonspecific nodule. Though most masses that require evaluation are ultimately benign, the possibility of a more aggressive process, including borderline or malignant neoplasms, underscores the pivotal role of the pediatric dermatologist in recognizing these lesions. The aim of this review is to provide an overview of lumps and bumps that are important to recognize to prevent delay in diagnosis or treatment of a serious underlying condition. Clinical clues that may lead the pediatric dermatologist to have a higher index of suspicion for more aggressive lesions are reviewed. Suggestions for evaluation and workup, as well as tips for the difficult to discern lesion, are proposed.

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Overview of the clinical and imaging features of the most common non-rhabdomyosarcoma soft-tissue sarcomas

Cited by 11 publications

References 27 publications

Complex management of a large retroperitoneal undifferentiated sarcoma encasing the abdominal aorta in a pediatric patient: a case report and review

Complex management of a large retroperitoneal undifferentiated sarcoma encasing the abdominal aorta in a pediatric patient: a case report and review

A flap graft technique for the reconstruction of extensor mechanism of the knee in a case of peri-articular synovial sarcoma managed by limb salvage

Lumps and bumps: What not to miss

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